p53

[Cell Biology and Toxicology] Researchers revealed that USP39 was associated with colon cancer cells sensitivity to cisplatin. Depletion of USP39 enhanced the cisplatin-induced apoptosis in HCT116 cells.

[Cardiovascular Toxicology] Researchers investigated the protective effects of Metoprolol against arginine vasopressin-induced cellular senescence in cultured cardiomyocytes.

[Oncogene] Scientists detected prominent RUNX3/Runx3 expression in human and mouse p53-deficient osteosarcoma and showed that p53 deficiency promoted osteosarcomagenesis in human and mouse by allowing Runx3 to induce oncogenic Myc expression.

[Cancer Gene Therapy] Investigators uncovered that the transcription factor p53 could upregulate miR-519d-3p expression to directly suppress the expression of E2F transcription factor 1 (E2F1), thus inhibiting prostate cancer growth and metastasis.

[Oncogene] The tumor suppressor gene TP53 is the most frequently mutated gene in numerous cancer types, including prostate cancer (PCa). Investigators found that mutant p53 acted in a context-dependent manner to elicit pro-tumorigenic transcriptional profiles.

[Bioengineered] Scientists investigated the functional role of glycogen synthase 2 in the progression of intrahepatic cholangiocarcinoma and explored the underlying mechanism.