Transcription Factor p53-Mediated Activation of miR-519d-3p and Downregulation of E2F1 Attenuates Prostate Cancer Growth and Metastasis

Investigators uncovered that the transcription factor p53 could upregulate miR-519d-3p expression to directly suppress the expression of E2F transcription factor 1 (E2F1), thus inhibiting prostate cancer growth and metastasis.