m6A Demethylase FTO Induces NELL2 Expression by Inhibiting E2F1 m6A Modification Leading to Metastasis of Non-Small-Cell Lung Cancer

Scientists explored the regulatory role of E2F transcription factor-1 and underlying mechanism in non-small-cell lung cancer development.
[Molecular Therapy-Oncolytics]
Wang, Y., Li, M., Zhang, L., Chen, Y., & Zhang, S. (2021). m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small-cell lung cancer. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.04.011 Cite
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Unravelling Heterogeneity of Amplified Human Amniotic Fluid Stem Cells Sub-Populations

In order to understand the intrapopulation heterogeneity, various fractions of human amniotic fluid stem cells were isolated using the Celector® profile and live imaging feature. The gene expression profile of each fraction was analysed using whole-transcriptome sequencing.
[Cells]
Casciaro, F., Zia, S., Forcato, M., Zavatti, M., Beretti, F., Bertucci, E., Zattoni, A., Reschiglian, P., Alviano, F., Bonsi, L., Follo, M. Y., Demaria, M., Roda, B., & Maraldi, T. (2021). Unravelling Heterogeneity of Amplified Human Amniotic Fluid Stem Cells Sub-Populations. Cells, 10(1), 158. https://doi.org/10.3390/cells10010158 Cite
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CKAP2L Promotes Non-Small Cell Lung Cancer Progression through Regulation of Transcription Elongation

Through an RNAi screen performed on genes involved in chromosomal instability and overexpressed in human lung adenocarcinoma samples, scientists identified the cytoskeleton-associated protein 2-like as a potential oncogene that promotes lung cancer proliferation and growth in vitro and in vivo.
[Cancer Research]
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LncRNA MYLK-AS1 Facilitates Tumor Progression and Angiogenesis by Targeting miR-424-5p/E2F7 Axis and Activating VEGFR-2 Signaling Pathway in Hepatocellular Carcinoma

Human HCC cell lines were used to evaluate the colony formation, cell proliferation, migration, invasion, cell cycle and apoptosis after transfection of lentiviral short-hairpin RNAs (shRNAs) targeting MYLK-AS1 or MYLK-AS1 vectors.
[Journal of Experimental & Clinical Cancer Research]
Teng, F., Zhang, J.-X., Chang, Q.-M., Wu, X.-B., Tang, W.-G., Wang, J.-F., Feng, J.-F., Zhang, Z.-P., & Hu, Z.-Q. (2020). LncRNA MYLK-AS1 facilitates tumor progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGFR-2 signaling pathway in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 39(1), 235. https://doi.org/10.1186/s13046-020-01739-z Cite
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All-Trans Retinoic Acid Prevented Vein Grafts Stenosis by Inhibiting Rb-E2F Mediated Cell Cycle Progression and KLF5-RARα Interaction in Human Vein Smooth Muscle Cells

All-trans retinoic acid (ATRA) could repress the PDGF-bb-induced excessive proliferation and migration of human umbilical vein smooth muscle cells, which was mediated by Rb-E2F dependent cell cycle inhibition.
[Cardiovascular Drugs and Therapy]

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The Transcription Factor C/EBPβ Orchestrates Dendritic Cell Maturation and Functionality Under Homeostatic and Malignant Conditions

Investigators found that IL-33 expression in a large subset of human glioma specimens and murine models correlated with increased tumor-associated macrophages/monocytes/microglia. In addition, nuclear and secreted functions of IL-33 regulated chemokines that collectively recruit and activated circulating and resident innate immune cells creating a pro-tumorigenic environment.
[Proceedings of the National Academy of Sciences of the United States of America]
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A., & Höpken, U. E. (2020). The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2008883117 Cite
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E2F7−EZH2 Axis Regulates PTEN/AKT/mTOR Signaling and Glioblastoma Progression

Functional studies showed that E2F7 promoted cell proliferation, cell-cycle progression, cell metastasis and tumorigenicity abilities in vitro and in vivo.
[British Journal of Cancer]
Yang, R., Wang, M., Zhang, G., Bao, Y., Wu, Y., Li, X., Yang, W., & Cui, H. (2020). E2F7−EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression. British Journal of Cancer, 1–11. https://doi.org/10.1038/s41416-020-01032-y Cite
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HIF-1α and HIF-2α Differently Regulate Tumor Development and Inflammation of Clear Cell Renal Cell Carcinoma in Mice

Investigators showed using an autochthonous clear cell renal cell carcinomas model that Hif1a was essential for tumor formation whereas Hif2a deletion had only minor effects on tumor initiation and growth.
[Nature Communications]
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