E2F

[Cell Death Discovery] Scientists explored the ability of gastric cancer (GC) cell-derived extracellular vesicles (EVs)-mediated microRNA-129-5p/E2F transcription factor 7/mitogen-activated protein kinase/extracellular regulated protein kinase axis to affect the peritoneal metastasis of GC by delivering lncRNA small nucleolar RNA host gene 12.

[Bioengineered] Researchers explored the potential mechanism of exosome-derived miR-631 targeting and regulating E2F family of transcription factor 2 to repress the malignant behavior of NSCLC cells.

[Cell Death & Disease] Researchers found that the expression of CMTM6 was significantly reduced in HCC and predicted better prognosis of HCC patients. Through in vitro and in vivo experiments, CMTM6 was shown to inhibit the proliferation of HCC cells by blocking the G1/S phase transition.

[Cancer Gene Therapy] Investigators unveiled the mechanism underlying long intergenic nonprotein coding RNA 0649 (LINC00649) in lung squamous cell carcinoma (LUSC) cells. As a result, LINC00649 was discovered to be with high expression in LUSC cells.

[Oncogene] Researchers investigated the function of the oncogenic BAP1/ASXL3/BRD4 epigenetic axis in small cell lung cancer by developing a next-generation BAP1 inhibitor.

[Molecular Therapy] Researchers demonstrated that retinoblastoma (Rb) family proteins played a central role in maintaining the global chromatin binding and transcriptional repression program of androgen receptor, and that Rb inactivation desensitized CRPC to the high-dose testosterone treatment in vitro and in vivo.