Scientists explored the regulatory role of E2F transcription factor-1 and underlying mechanism in non-small-cell lung cancer development.
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In order to understand the intrapopulation heterogeneity, various fractions of human amniotic fluid stem cells were isolated using the Celector® profile and live imaging feature. The gene expression profile of each fraction was analysed using whole-transcriptome sequencing.
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Casciaro, F., Zia, S., Forcato, M., Zavatti, M., Beretti, F., Bertucci, E., Zattoni, A., Reschiglian, P., Alviano, F., Bonsi, L., Follo, M. Y., Demaria, M., Roda, B., & Maraldi, T. (2021). Unravelling Heterogeneity of Amplified Human Amniotic Fluid Stem Cells Sub-Populations. Cells, 10(1), 158. https://doi.org/10.3390/cells10010158 Cite
Through an RNAi screen performed on genes involved in chromosomal instability and overexpressed in human lung adenocarcinoma samples, scientists identified the cytoskeleton-associated protein 2-like as a potential oncogene that promotes lung cancer proliferation and growth in vitro and in vivo.
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Human HCC cell lines were used to evaluate the colony formation, cell proliferation, migration, invasion, cell cycle and apoptosis after transfection of lentiviral short-hairpin RNAs (shRNAs) targeting MYLK-AS1 or MYLK-AS1 vectors.
[Journal of Experimental & Clinical Cancer Research]
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Teng, F., Zhang, J.-X., Chang, Q.-M., Wu, X.-B., Tang, W.-G., Wang, J.-F., Feng, J.-F., Zhang, Z.-P., & Hu, Z.-Q. (2020). LncRNA MYLK-AS1 facilitates tumor progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGFR-2 signaling pathway in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 39(1), 235. https://doi.org/10.1186/s13046-020-01739-z Cite
All-trans retinoic acid (ATRA) could repress the PDGF-bb-induced excessive proliferation and migration of human umbilical vein smooth muscle cells, which was mediated by Rb-E2F dependent cell cycle inhibition.
[Cardiovascular Drugs and Therapy]
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Investigators found that IL-33 expression in a large subset of human glioma specimens and murine models correlated with increased tumor-associated macrophages/monocytes/microglia. In addition, nuclear and secreted functions of IL-33 regulated chemokines that collectively recruit and activated circulating and resident innate immune cells creating a pro-tumorigenic environment.
[Proceedings of the National Academy of Sciences of the United States of America]
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Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A., & Höpken, U. E. (2020). The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2008883117 Cite
Functional studies showed that E2F7 promoted cell proliferation, cell-cycle progression, cell metastasis and tumorigenicity abilities in vitro and in vivo.
[British Journal of Cancer]
Investigators showed using an autochthonous clear cell renal cell carcinomas model that Hif1a was essential for tumor formation whereas Hif2a deletion had only minor effects on tumor initiation and growth.