Exploiting the Tumor-Suppressive Activity of the Androgen Receptor by CDK4/6 Inhibition in Castration-Resistant Prostate Cancer

Researchers demonstrated that retinoblastoma (Rb) family proteins played a central role in maintaining the global chromatin binding and transcriptional repression program of androgen receptor, and that Rb inactivation desensitized CRPC to the high-dose testosterone treatment in vitro and in vivo.