Exosomal LINC00174 Derived from Vascular Endothelial Cells Attenuates Myocardial Ischemia-Reperfusion Injury via p53-Mediated Autophagy and Apoptosis

The authors investigated the regulation of specific long non-coding RNAs on the progression of ischemia/reperfusion injury. They identified and characterized the exosomes derived from mouse primary aortic endothelial cells.
[Molecular Therapy-Nucleic Acids]
Su, Q., Lv, X.-W., Xu, Y.-L., Cai, R.-P., Dai, R.-X., Yang, X.-H., Zhao, W.-K., & Kong, B.-H. (2021). Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial Ischemia-Reperfusion Injury via p53-mediated autophagy and apoptosis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.005 Cite
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MiR-18a Promotes Glioblastoma Development by Down-Regulating ALOXE3-Mediated Ferroptotic and Anti-Migration Activities

Researchers explored the expression and functional roles of lipoxygenases (LOXs) in the development of glioblastoma (GBM). They showed that ALOXE3 was markedly down-regulated in human GBM.
[Oncogenesis]
miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities | Oncogenesis. (n.d.). Retrieved February 13, 2021, from https://www.nature.com/articles/s41389-021-00304-3 Cite
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Genomic Aberrations after Short-Term Exposure to Colibactin-Producing E. coli Transform Primary Colon Epithelial Cells

Colibactin’s distinct mutational signature is reflected in human colorectal cancer, suggesting a causal link. Scientists investigated its transformation potential using organoids from primary murine colon epithelial cells.
[Nature Communications]
Iftekhar, A., Berger, H., Bouznad, N., Heuberger, J., Boccellato, F., Dobrindt, U., Hermeking, H., Sigal, M., & Meyer, T. F. (2021). Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells. Nature Communications, 12(1), 1003. https://doi.org/10.1038/s41467-021-21162-y Cite
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Microvesicles Mediate Sorafenib Resistance in Liver Cancer Cells through Attenuating p53 and Enhancing FOXM1 Expression

Investigators report the effects of liver cancer cell-secreted microvesicles on sorafenib resistance in liver cancer cells HepG2 and Huh7 both in vitro and in vivo.
[Life Sciences]
Jaffar Ali, D., He, C., Xu, H., Kumaravel, S., Sun, B., Zhou, Y., Liu, R., & Xiao, Z. (2021). Microvesicles mediate sorafenib resistance in liver cancer cells through attenuating p53 and enhancing FOXM1 expression. Life Sciences, 271, 119149. https://doi.org/10.1016/j.lfs.2021.119149 Cite
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NAMPT/SIRT2-Mediated Inhibition of the p53-p21 Signaling Pathway Is Indispensable for Maintenance and Hematopoietic Differentiation of Human iPS Cells

Investigators demonstrated that nicotinamide phosphoribosyltransferase (NAMPT) is indispensable for the maintenance, survival, and hematopoietic differentiation of induced pluripotent stem cells.
[Stem Cell Research & Therapy]
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Mutant p53 Suppresses Innate Immune Signaling to Promote Tumorigenesis

Researchers report a mechanism by which mtp53 suppressed both cell-autonomous and non-cell-autonomous signaling to promote cancer cell survival and evasion of tumor immune surveillance.
[Cancer Cell]
Ghosh, M., Saha, S., Bettke, J., Nagar, R., Parrales, A., Iwakuma, T., Velden, A. W. M. van der, & Martinez, L. A. (2021). Mutant p53 suppresses innate immune signaling to promote tumorigenesis. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2021.01.003 Cite
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The Delivery of Hsa-miR-11401 by Extracellular Vesicles Can Relieve Doxorubicin-Induced Mesenchymal Stem Cell Apoptosis

Doxorubicin, a commonly used chemotherapy drug, was used to treat human umbilical cord-derived MSCs for six hours as an in vitro cell model of chemotherapy-induced damage.
[Stem Cell Research & Therapy]
Li, H., Huang, H., Chen, X., Chen, S., Yu, L., Wang, C., Liu, Y., Zhang, K., Wu, L., Han, Z.-C., Liu, N., Wu, J., & Li, Z. (2021). The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis. Stem Cell Research & Therapy, 12(1), 77. https://doi.org/10.1186/s13287-021-02156-5 Cite
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Identification of Potential Novel Drug Resistance Mechanisms by Genomic and Transcriptomic Profiling of Colon Cancer Cells with p53 Deletion

The authors characterized colon cancer cells with TP53 deletion, a sub-line derived from HCT116-p53+/+ cells. RNA sequencing and network analyses were performed to identify novel drug resistance mechanisms.
[Archives of Toxicology]
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Potential Chemotherapeutic Effect of Betalain against Human Non‐Small Cell Lung Cancer through PI3K/Akt/mTOR Signaling Pathway

Investigators demonstrated that betalain was able to reduce the viability of A549 cells dose dependently with undetectable toxicity toward normal human cells.
[Environmental Toxicology]
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Inhibition of MDM2 Promotes Anti-Tumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment

To investigate the role of p53 in controlling tumor-immune cell crosstalk, scientists studied murine syngeneic models treated with HDM201, a potent and selective second generation MDM2 inhibitor.
[Cancer Research]
Wang, H. Q., Mulford, I. J., Sharp, F., Liang, J., Kurtulus, S., Trabucco, G., Quinn, D. S., Longmire, T. A., Patel, N., Patil, R., Shirley, M. D., Chen, Y., Wang, H., Ruddy, D. A., Fabre, C., Williams, J. A., Hammerman, P. S., Mataraza, J., Platzer, B., & Halilovic, E. (2021). Inhibition of MDM2 promotes anti-tumor responses in p53 wild-type cancer cells through their interaction with the immune and stromal microenvironment. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0189 Cite
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Unravelling Heterogeneity of Amplified Human Amniotic Fluid Stem Cells Sub-Populations

In order to understand the intrapopulation heterogeneity, various fractions of human amniotic fluid stem cells were isolated using the Celector® profile and live imaging feature. The gene expression profile of each fraction was analysed using whole-transcriptome sequencing.
[Cells]
Casciaro, F., Zia, S., Forcato, M., Zavatti, M., Beretti, F., Bertucci, E., Zattoni, A., Reschiglian, P., Alviano, F., Bonsi, L., Follo, M. Y., Demaria, M., Roda, B., & Maraldi, T. (2021). Unravelling Heterogeneity of Amplified Human Amniotic Fluid Stem Cells Sub-Populations. Cells, 10(1), 158. https://doi.org/10.3390/cells10010158 Cite
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