The authors investigated the regulation of specific long non-coding RNAs on the progression of ischemia/reperfusion injury. They identified and characterized the exosomes derived from mouse primary aortic endothelial cells.
[Molecular Therapy-Nucleic Acids]
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Su, Q., Lv, X.-W., Xu, Y.-L., Cai, R.-P., Dai, R.-X., Yang, X.-H., Zhao, W.-K., & Kong, B.-H. (2021). Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial Ischemia-Reperfusion Injury via p53-mediated autophagy and apoptosis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.005 Cite
Researchers explored the expression and functional roles of lipoxygenases (LOXs) in the development of glioblastoma (GBM). They showed that ALOXE3 was markedly down-regulated in human GBM.
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miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities | Oncogenesis. (n.d.). Retrieved February 13, 2021, from https://www.nature.com/articles/s41389-021-00304-3 Cite
Colibactin’s distinct mutational signature is reflected in human colorectal cancer, suggesting a causal link. Scientists investigated its transformation potential using organoids from primary murine colon epithelial cells.
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Iftekhar, A., Berger, H., Bouznad, N., Heuberger, J., Boccellato, F., Dobrindt, U., Hermeking, H., Sigal, M., & Meyer, T. F. (2021). Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells. Nature Communications, 12(1), 1003. https://doi.org/10.1038/s41467-021-21162-y Cite
Investigators report the effects of liver cancer cell-secreted microvesicles on sorafenib resistance in liver cancer cells HepG2 and Huh7 both in vitro and in vivo.
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Investigators demonstrated that nicotinamide phosphoribosyltransferase (NAMPT) is indispensable for the maintenance, survival, and hematopoietic differentiation of induced pluripotent stem cells.
[Stem Cell Research & Therapy]
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Researchers report a mechanism by which mtp53 suppressed both cell-autonomous and non-cell-autonomous signaling to promote cancer cell survival and evasion of tumor immune surveillance.
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Doxorubicin, a commonly used chemotherapy drug, was used to treat human umbilical cord-derived MSCs for six hours as an in vitro cell model of chemotherapy-induced damage.
[Stem Cell Research & Therapy]
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Li, H., Huang, H., Chen, X., Chen, S., Yu, L., Wang, C., Liu, Y., Zhang, K., Wu, L., Han, Z.-C., Liu, N., Wu, J., & Li, Z. (2021). The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis. Stem Cell Research & Therapy, 12(1), 77. https://doi.org/10.1186/s13287-021-02156-5 Cite
The authors characterized colon cancer cells with TP53 deletion, a sub-line derived from HCT116-p53+/+ cells. RNA sequencing and network analyses were performed to identify novel drug resistance mechanisms.
[Archives of Toxicology]
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Investigators demonstrated that betalain was able to reduce the viability of A549 cells dose dependently with undetectable toxicity toward normal human cells.
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To investigate the role of p53 in controlling tumor-immune cell crosstalk, scientists studied murine syngeneic models treated with HDM201, a potent and selective second generation MDM2 inhibitor.
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Wang, H. Q., Mulford, I. J., Sharp, F., Liang, J., Kurtulus, S., Trabucco, G., Quinn, D. S., Longmire, T. A., Patel, N., Patil, R., Shirley, M. D., Chen, Y., Wang, H., Ruddy, D. A., Fabre, C., Williams, J. A., Hammerman, P. S., Mataraza, J., Platzer, B., & Halilovic, E. (2021). Inhibition of MDM2 promotes anti-tumor responses in p53 wild-type cancer cells through their interaction with the immune and stromal microenvironment. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0189 Cite
In order to understand the intrapopulation heterogeneity, various fractions of human amniotic fluid stem cells were isolated using the Celector® profile and live imaging feature. The gene expression profile of each fraction was analysed using whole-transcriptome sequencing.
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Casciaro, F., Zia, S., Forcato, M., Zavatti, M., Beretti, F., Bertucci, E., Zattoni, A., Reschiglian, P., Alviano, F., Bonsi, L., Follo, M. Y., Demaria, M., Roda, B., & Maraldi, T. (2021). Unravelling Heterogeneity of Amplified Human Amniotic Fluid Stem Cells Sub-Populations. Cells, 10(1), 158. https://doi.org/10.3390/cells10010158 Cite