Glutamine-fructose-6-phosphate transaminase [isomerizing] 2 inhibition selectively reduced KRAS/LKB1 co-mutant tumour cell growth in culture, xenografts and genetically modified mice.
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Kim, J., Lee, H. M., Cai, F., Ko, B., Yang, C., Lieu, E. L., Muhammad, N., Rhyne, S., Li, K., Haloul, M., Gu, W., Faubert, B., Kaushik, A. K., Cai, L., Kasiri, S., Marriam, U., Nham, K., Girard, L., Wang, H., … DeBerardinis, R. J. (2020). The hexosamine biosynthesis pathway is a targetable liability in KRAS / LKB1 mutant lung cancer. Nature Metabolism, 1–12. https://doi.org/10.1038/s42255-020-00316-0 Cite
PMV Pharmaceuticals, Inc. announced dosing of the first patient in its Phase I/II clinical trial evaluating PC14586, the company’s investigational lead compound that targets the Y220C mutant of p53.
[PMV Pharmaceuticals, Inc.]
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Overexpression of regucalcin in bone metastatic human prostate cancer PC-3 and DU-145 cells suppressed colony formation and cell growth in vitro. Overexpressed regucalcin enhanced the levels of p53, Rb, and p21, and decreased the levels of Ras, PI3 kinase, Akt, and mitogen-activated protein kinase, leading to suppression of cell growth.
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Yamaguchi, M., Osuka, S., Murata, T., & Ramos, J. W. (2021). Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells. Translational Oncology, 14(1), 100955. https://doi.org/10.1016/j.tranon.2020.100955 Cite
The authors investigated the role and the underlying regulatory mechanism of ubiquitin specific peptidase 7 (USP7) in myocardial infarction.
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In order to evaluate the effect of chemically mimicked hypoxia on human PSCs cell survival, scientists analyzed changes in cell viability and several aspects of apoptosis triggered by CoCl2 and dimethyloxalylglycine.
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Isaja, L., Mucci, S., Vera, J., Rodríguez-Varela, M. S., Marazita, M., Morris-Hanon, O., Videla-Richardson, G. A., Sevlever, G. E., Scassa, M. E., & Romorini, L. (2020). Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism. Scientific Reports, 10(1), 20653. https://doi.org/10.1038/s41598-020-77792-7 Cite
PIDDosome deficiency reduced tumor number and burden, despite the inability to activate p53 in polyploid cells. Liver tumors arose primarily from cells with low ploidy, indicating an intrinsic pro‐tumorigenic effect of PIDDosome‐mediated ploidy restriction.
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Sladky, V. C., Knapp, K., Szabo, T. G., Braun, V. Z., Bongiovanni, L., van den Bos, H., Spierings, D. C., Westendorp, B., Curinha, A., Stojakovic, T., Scharnagl, H., Timelthaler, G., Tsuchia, K., Pinter, M., Semmler, G., Foijer, F., de Bruin, A., Reiberger, T., Rohr-Udilova, N., & Villunger, A. (2020). PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis. EMBO Reports, n/a(n/a), e50893. https://doi.org/10.15252/embr.202050893 Cite
Researchers demonstrated that supt16h, a component of the facilitates chromatin transcription complex, is required for hematopoietic stem and progenitor cell formation.
[Nature Cell Biology]
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Researchers established myostatin (MSTN) knockout quail myoblasts and investigated the regulatory pathway of the myogenic differentiation process.
[Molecular Biology Reports]
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Investigators determine the phenotypic responses of DMD cardiomyocytes (DMD-iCMs) after long-term exposure to DMD cardiac exosomes. DMD-iCMs were vulnerable to stress, evidenced by production of reactive oxygen species, the mitochondrial membrane potential and cell death levels.
[Disease Models & Mechanisms]
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Scientists report that DEP-domain containing mTOR-interacting protein (DEPTOR) is a downstream target of the tumor suppressor, p53, whose activity is positively correlated with DEPTOR expression both in vitro in cell cultures and in vivo in mouse tissues.
[Cell Death & Disease]
Scientists clarified how coffee decoction exerts anti-cancer effects in cooperation with tamoxifen using the estrogen receptor α-positive breast cancer cell line, MCF-7.