Regulation of Amyloid-β Levels by Matrix Metalloproteinase-2/9 (MMP2/9) in the Media of Lung Cancer Cells

identify regulators of intact amyloid-β40/42 (Aβ) levels in A549 (p53 wild-type) and H1299 (p53-null) lung cancer cell media.
[Scientific Reports]
Dorandish, S., Williams, A., Atali, S., Sendo, S., Price, D., Thompson, C., Guthrie, J., Heyl, D., & Evans, H. G. (2021). Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells. Scientific Reports, 11(1), 9708. https://doi.org/10.1038/s41598-021-88574-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Expression Levels and Activation Status of Yap Splicing Isoforms Determine Self-Renewal and Differentiation Potential of Embryonic Stem Cells

Scientists identify two Yap splicing isoforms, which showed equal expression levels but heterogeneous distribution in ESCs.
[Stem Cells]
Wang, X., Ruan, Y., Zhang, J., Tian, Y., Liu, L., Wang, J., Liu, G., Cheng, Y., Xu, Y., Yang, Y., Yu, M., Zhao, B., Zhang, Y., Wang, J., Wang, J., Wu, W., He, P., Xiao, L., Xiong, J., & Jian, R. (n.d.). Expression levels and activation status of Yap splicing isoforms determine self-renewal and differentiation potential of embryonic stem cells. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3389 Cite
Abstract
Bookmark

No account yet? Register

0
Share

ITIH5, a p53-Responsive Gene, Inhibits the Growth and Metastasis of Melanoma Cells by Downregulating the Transcriptional Activity of KLF4

Scientists found that the expression of ITIH5 was decreased in melanoma tissues compared with normal skin tissues.
[Cell Death & Disease]
Liu, J., Cao, F., Li, X., Zhang, L., Liu, Z., Li, X., Lin, J., & Han, C. (2021). ITIH5, a p53-responsive gene, inhibits the growth and metastasis of melanoma cells by downregulating the transcriptional activity of KLF4. Cell Death & Disease, 12(5), 1–15. https://doi.org/10.1038/s41419-021-03707-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Anti-cancer & Anti-metastasis Properties of Bioorganic-Capped Silver Nanoparticles Fabricated from Juniperus chinensis Extract against Lung Cancer Cells

The authors elucidated the cellular and molecular mechanisms of nanoparticles for anti-proliferative and apoptotic effects on human lung cancer cells and compared them with commercial drug cisplatin.
[Amb Express]
Noorbazargan, H., Amintehrani, S., Dolatabadi, A., Mashayekhi, A., Khayam, N., Moulavi, P., Naghizadeh, M., Mirzaie, A., Mirzaei rad, F., & Kavousi, M. (2021). Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells. AMB Express, 11(1), 61. https://doi.org/10.1186/s13568-021-01216-6 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Principles of Signaling Pathway Modulation for Enhancing Human Naive Pluripotency Induction

Scientists devised enhanced conditions that enabled stabilization of hPSCs with stringent naive functional and molecular properties while preserving cell-autonomous differentiation competence into embryonic, germ cell and extra-embryonic lineages.
[Cell Stem Cell]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

The Nek2 Centrosome-Mitotic Kinase Contributes to the Mesenchymal State, Cell Invasion, and Migration of Triple-Negative Breast Cancer Cells

Investigators report that overexpression of NIMA‐related kinase 2 (Nek2) in MCF10A cells drove centrosome amplification/chromosome instability and aneuploidy.
[Scientific Reports]
Rivera-Rivera, Y., Marina, M., Jusino, S., Lee, M., Velázquez, J. V., Chardón-Colón, C., Vargas, G., Padmanabhan, J., Chellappan, S. P., & Saavedra, H. I. (2021). The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells. Scientific Reports, 11(1), 9016. https://doi.org/10.1038/s41598-021-88512-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Low Magnitude Vibration Alleviates Age-Related Bone Loss by Inhibiting Cell Senescence of Osteogenic Cells in Naturally Senescent Rats

Researchers found osteogenic cells from aged rats all exhibited senescence changes, with the most pronounced senescence changes in osteocytes. Meanwhile, the proliferative capacity and functional activity of osteogenic cells from aged rats were suppressed.
[Aging]
Aging | Low magnitude vibration alleviates age-related bone loss by inhibiting cell senescence of osteogenic cells in naturally senescent rats - Full Text. (n.d.). Retrieved April 23, 2021, from https://www.aging-us.com/article/202907/text Cite
Full Article
Bookmark

No account yet? Register

0
Share

Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines

The toxicity of Gemini-Cur on HT-29 and HCT116 was studied through MTT, uptake kinetics, fluorescence microscopy, annexin V/FITC, and cell cycle assays.
[International Journal of Pharmaceutics]
Ebrahimi, M., Babaei, E., Neri, F., & Feizi, M. A. H. (2021). Anti-proliferative and apoptotic effect of gemini curcumin in p53-wild type and p53-mutant colorectal cancer cell lines. International Journal of Pharmaceutics, 601, 120592. https://doi.org/10.1016/j.ijpharm.2021.120592 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Amyloid Precursor Protein Elevates Fusion of Promyelocytic Leukemia Nuclear Bodies in Human Hippocampal Areas with High Plaque Load

Researchers showed that the nuclear aggregates of APP-CT50 fragments together with PML and FE65 are present in the aged human brain but not in cerebral organoids differentiated from iPS cells.
[Acta Neuropathologica Communications]
Marks, D., Heinen, N., Bachmann, L., Meermeyer, S., Werner, M., Gallego, L., Hemmerich, P., Bader, V., Winklhofer, K. F., Schröder, E., Knauer, S. K., & Müller, T. (2021). Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load. Acta Neuropathologica Communications, 9(1), 66. https://doi.org/10.1186/s40478-021-01174-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

A Novel 4D Cell Culture Mimicking Stomach Peristalsis Altered Gastric Cancer Spheroids Growth and Malignance

Scientists leveraged a lab-developed four-dimensional culture model by a magnetic responsive alginate-based hydrogel to rotating magnets that can mimic stress stimuli in gastric cancer.
[Biofabrication]
Zhao, J., Wang, R., Zhang, J., Zhao, Y., Qiao, S., Crouzier, T., Yan, H., & Tian, W. (2021). A novel 4D cell culture mimicking stomach peristalsis altered gastric cancer spheroids growth and malignance. Biofabrication. https://doi.org/10.1088/1758-5090/abf6bf Cite
Abstract
Bookmark

No account yet? Register

0
Share

Brd4-Bound Enhancers Drive Cell-Intrinsic Sex Differences in Glioblastoma

Researchers discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks, large Brd4-bound enhancer usage, and Brd4 localization to Myc and p53 genomic binding sites. These sex-biased gene expression patterns were also evident in human glioblastoma stem cells.
[Proceedings of the National Academy of Sciences of the United States of America]
Kfoury, N., Qi, Z., Prager, B. C., Wilkinson, M. N., Broestl, L., Berrett, K. C., Moudgil, A., Sankararaman, S., Chen, X., Gertz, J., Rich, J. N., Mitra, R. D., & Rubin, J. B. (2021). Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma. Proceedings of the National Academy of Sciences, 118(16). https://doi.org/10.1073/pnas.2017148118 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share