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p53

Caspase-9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis

[Molecular Cancer Research] A transgenic mouse model expressing human Caspase-9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive MDSCs in contrast to wild-type mice.

Peripheral Blood CD4+CCR6+ Compartment Differentiates HIV-1 Infected or Seropositive Elite Controllers from Long-Term Successfully Treated Individuals

[Communications Biology] Scientists showed how people living with HIV-1 (PLWH) who naturally control the virus had a reduced proportion of CD4+CCR6+ and CD8+CCR6+ cells compared to PLWH on suppressive antiretroviral therapy and HIV-1 negative controls.

ZMAT1 Acts as a Tumor Suppressor in Pancreatic Ductal Adenocarcinoma by Inducing SIRT3/p53 Signaling Pathway

[Journal of Experimental & Clinical Cancer Research] Multiple bioinformatics analyses were used to evaluate zinc finger matrin-type 1 (ZMAT1) expression and potential role in PDAC.In vitro and in vivo studies were performed to assess the effects of ZMAT1 on PDAC cells growth.

Mechano-Signaling via Piezo1 Prevents Activation and p53-Mediated Senescence of Muscle Stem Cells

[Redox Biology] The authors described that Piezo1, a mechanosensitive ion channel, keeps skeletal muscle stem cells in a quiescent state and prevented senescence.

Application of a Fluorescent H2S Probe Based on Excited-State Intramolecular Proton Transfer for Detecting Latent Mechanism of H2S-Induced MCF-7 Apoptosis

[Future Medicinal Chemistry] FHS-1 was synthesized utilizing excited-state intramolecular proton transfer to detect H2S in MCF-7 cells, and investigated the effects of varying concentrations NaHS on apoptosis.

Identification of Biomarkers Associated with Hepatocellular Carcinoma Stem Cell Characteristics Based on Co-Expression Network Analysis of Transcriptome Data and Stemness Index

[Critical Reviews in Eukaryotic Gene Expression] Significant genes associated hepatocellular carcinoma stemness features were screened through weighted gene co-expression network analysis and were functionally annotated using enrichment analysis.

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