The Hexosamine Biosynthesis Pathway Is a Targetable Liability in KRAS/LKB1 Mutant Lung Cancer

Glutamine-fructose-6-phosphate transaminase [isomerizing] 2 inhibition selectively reduced KRAS/LKB1 co-mutant tumour cell growth in culture, xenografts and genetically modified mice.
[Nature Metabolism]
Kim, J., Lee, H. M., Cai, F., Ko, B., Yang, C., Lieu, E. L., Muhammad, N., Rhyne, S., Li, K., Haloul, M., Gu, W., Faubert, B., Kaushik, A. K., Cai, L., Kasiri, S., Marriam, U., Nham, K., Girard, L., Wang, H., … DeBerardinis, R. J. (2020). The hexosamine biosynthesis pathway is a targetable liability in KRAS / LKB1 mutant lung cancer. Nature Metabolism, 1–12. https://doi.org/10.1038/s42255-020-00316-0 Cite
Abstract
Bookmark

No account yet? Register

0
Share

PMV Pharma Doses First Patient in Phase I/II Study of PC14586, a First-in-Class Precision Oncology Therapy that Targets Mutant p53

PMV Pharmaceuticals, Inc. announced dosing of the first patient in its Phase I/II clinical trial evaluating PC14586, the company’s investigational lead compound that targets the Y220C mutant of p53.
[PMV Pharmaceuticals, Inc.]
Press Release
Bookmark

No account yet? Register

0
Share

Progression-Free Survival of Prostate Cancer Patients Is Prolonged with a Higher Regucalcin Expression in the Tumor Tissues: Overexpressed Regucalcin Suppresses the Growth and Bone Activity in Human Prostate Cancer Cells

Overexpression of regucalcin in bone metastatic human prostate cancer PC-3 and DU-145 cells suppressed colony formation and cell growth in vitro. Overexpressed regucalcin enhanced the levels of p53, Rb, and p21, and decreased the levels of Ras, PI3 kinase, Akt, and mitogen-activated protein kinase, leading to suppression of cell growth.
[Translational Oncology]
Yamaguchi, M., Osuka, S., Murata, T., & Ramos, J. W. (2021). Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells. Translational Oncology, 14(1), 100955. https://doi.org/10.1016/j.tranon.2020.100955 Cite
Full Article
Bookmark

No account yet? Register

0
Share

USP7, Negatively Regulated by miR‐409‐5p, Aggravates Hypoxia‐Induced Cardiomyocyte Injury

The authors investigated the role and the underlying regulatory mechanism of ubiquitin specific peptidase 7 (USP7) in myocardial infarction.
[APMIS]
Xue, Q., Yang, D., Zhang, J., Gan, P., Lin, C., Lu, Y., Zhang, W., Zhang, L., & Guang, X. (n.d.). USP7, negatively regulated by miR-409-5p, aggravates hypoxia-induced cardiomyocyte injury. APMIS, n/a(n/a). https://doi.org/https://doi.org/10.1111/apm.13100 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Chemical Hypoxia Induces Apoptosis of Human Pluripotent Stem Cells by a NOXA-Mediated HIF-1α and HIF-2α Independent Mechanism

In order to evaluate the effect of chemically mimicked hypoxia on human PSCs cell survival, scientists analyzed changes in cell viability and several aspects of apoptosis triggered by CoCl2 and dimethyloxalylglycine.
[Scientific Reports]
Isaja, L., Mucci, S., Vera, J., Rodríguez-Varela, M. S., Marazita, M., Morris-Hanon, O., Videla-Richardson, G. A., Sevlever, G. E., Scassa, M. E., & Romorini, L. (2020). Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism. Scientific Reports, 10(1), 20653. https://doi.org/10.1038/s41598-020-77792-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

PIDDosome-Induced p53-Dependent Ploidy Restriction Facilitates Hepatocarcinogenesis

PIDDosome deficiency reduced tumor number and burden, despite the inability to activate p53 in polyploid cells. Liver tumors arose primarily from cells with low ploidy, indicating an intrinsic pro‐tumorigenic effect of PIDDosome‐mediated ploidy restriction.
[EMBO Reports]
Sladky, V. C., Knapp, K., Szabo, T. G., Braun, V. Z., Bongiovanni, L., van den Bos, H., Spierings, D. C., Westendorp, B., Curinha, A., Stojakovic, T., Scharnagl, H., Timelthaler, G., Tsuchia, K., Pinter, M., Semmler, G., Foijer, F., de Bruin, A., Reiberger, T., Rohr-Udilova, N., & Villunger, A. (2020). PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis. EMBO Reports, n/a(n/a), e50893. https://doi.org/10.15252/embr.202050893 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Hematopoietic Stem Cell-Dependent Notch Transcription Is Mediated by p53 through the Histone Chaperone Supt16h

Researchers demonstrated that supt16h, a component of the facilitates chromatin transcription complex, is required for hematopoietic stem and progenitor cell formation.
[Nature Cell Biology]
Abstract
Bookmark

No account yet? Register

0
Share

Muscle Differentiation Induced by p53 Signaling Pathway-Related Genes in Myostatin-Knockout Quail Myoblasts

Researchers established myostatin (MSTN) knockout quail myoblasts and investigated the regulatory pathway of the myogenic differentiation process.
[Molecular Biology Reports]
Abstract
Bookmark

No account yet? Register

0
Share

Duchenne Muscular Dystrophy (DMD) Cardiomyocyte-Secreted Exosomes Promote the Pathogenesis of DMD-Associated Cardiomyopathy

Investigators determine the phenotypic responses of DMD cardiomyocytes (DMD-iCMs) after long-term exposure to DMD cardiac exosomes. DMD-iCMs were vulnerable to stress, evidenced by production of reactive oxygen species, the mitochondrial membrane potential and cell death levels.
[Disease Models & Mechanisms]
Gartz, M., Lin, C.-W., Sussman, M. A., Lawlor, M. W., & Strande, J. L. (2020). Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy. Disease Models & Mechanisms, 13(11). https://doi.org/10.1242/dmm.045559 Cite
Full Article
Bookmark

No account yet? Register

0
Share

DEPTOR Is a Direct p53 Target that Suppresses Cell Growth and Chemosensitivity

Scientists report that DEP-domain containing mTOR-interacting protein (DEPTOR) is a downstream target of the tumor suppressor, p53, whose activity is positively correlated with DEPTOR expression both in vitro in cell cultures and in vivo in mouse tissues.
[Cell Death & Disease]
Cui, D., Dai, X., Gong, L., Chen, X., Wang, L., Xiong, X., & Zhao, Y. (2020). DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity. Cell Death & Disease, 11(11), 1–13. https://doi.org/10.1038/s41419-020-03185-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Coffee Decoction Enhances Tamoxifen Proapoptotic Activity on MCF-7 Cells

Scientists clarified how coffee decoction exerts anti-cancer effects in cooperation with tamoxifen using the estrogen receptor α-positive breast cancer cell line, MCF-7.
[Scientific Reports]
Funakoshi-Tago, M., Tago, K., Li, C., Hokimoto, S., & Tamura, H. (2020). Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells. Scientific Reports, 10(1), 19588. https://doi.org/10.1038/s41598-020-76445-z Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share