Apigenin Enhanced Antitumor Effect of Cisplatin in Lung Cancer via Inhibition of Cancer Stem Cells

Scientists attempted to clarify whether apigenin could improve the antitumor efficiency of cisplatin in lung cancer using cancer stem cells.
[Nutrition and Cancer-An International Journal]
Li, Y., Chen, X., He, W., Xia, S., Jiang, X., Li, X., Bai, J., Li, N., Chen, L., & Yang, B. (2020). Apigenin Enhanced Antitumor Effect of Cisplatin in Lung Cancer via Inhibition of Cancer Stem Cells. Nutrition and Cancer, 0(0), 1–9. https://doi.org/10.1080/01635581.2020.1802494 Cite
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Inhibition of miR-1193 Leads to Synthetic Lethality in Glioblastoma Multiforme Cells Deficient of DNA-PKcs

By implementing a highly efficient high-throughput screening platform using an in-house-constructed genome-wide human microRNA inhibitor library, scientists demonstrated that miR-1193 inhibition sensitized glioblastoma multiforme tumor cells with DNA-PKcs deficiency.
[Cell Death & Disease]
Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs | Cell Death & Disease. (n.d.). Retrieved August 5, 2020, from https://www.nature.com/articles/s41419-020-02812-3 Cite
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Hotspot Mutant p53-R273H Inhibits KLF6 Expression to Promote Cell Migration and Tumor Metastasis

Scientists revealed an important role for EGFR–AKT–FOXO1–KLF6–E-cadherin axis in mutant p53-induced cell migration and tumor metastasis.
[Cell Death & Disease]
Sun, S., Chen, H., Sun, L., Wang, M., Wu, X., & Xiao, Z.-X. J. (2020). Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis. Cell Death & Disease, 11(7), 1–9. https://doi.org/10.1038/s41419-020-02814-1 Cite
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Mitoxantrone Triggers Immunogenic Prostate Cancer Cell Death via p53-Dependent PERK Expression

Immunogenic cell death was determined by assessing the release of damage-associated molecular patterns in the prostate cancer-derived cell lines LNCaP, 22RV1 and PC-3.
[Cellular Oncology]
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A Single Radioprotective Dose of Prostaglandin E2 Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells

16,16-dimethyl prostaglandin E2 suppressed hematopoietic stem cell proliferation through 24 hour post ionizing radiation, which correlated with fewer DNA double-strand breaks and attenuation of apoptosis, mitochondrial compromise, oxidative stress, and senescence.
[Stem Cell Reports]
Patterson, A. M., Liu, L., Sampson, C. H., Plett, P. A., Li, H., Singh, P., Mohammad, K. S., Hoggatt, J., Capitano, M. L., Orschell, C. M., & Pelus, L. M. (2020). A Single Radioprotective Dose of Prostaglandin E2 Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.07.004 Cite
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Hotspot Mutant p53-R273H Inhibits KLF6 Expression to Promote Cell Migration and Tumor Metastasis

Researchers demonstrated that hotspot mutant p53, p53-R273H, promoted cell scattering growth and migration via inhibiting the expression of Krupple-like factor 6 (KLF6), a Zinc finger transcription factor and a documented tumor suppressor.
[Cell Death & Disease]
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Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema.
[COPD-Journal of Chronic Obstructive Pulmonary Disease]
Gu, C., Zhang, Q., Ni, D., Xiao, Q.-F., Cao, L.-F., Fei, C.-Y., Ying, Y., Li, N., & Tao, F. (2020). Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. COPD: Journal of Chronic Obstructive Pulmonary Disease, 0(0), 1–8. https://doi.org/10.1080/15412555.2020.1797657 Cite
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Mithramycin Selectively Attenuates DNA-Damage-Induced Neuronal Cell Death

The authors suggested that Sp1 was required for p53-mediated transactivation of neuronal pro-apoptotic molecules and that mithramycin might have attenuated neuronal cell death in conditions predominantly involving DNA-damage-induced p53-dependent intrinsic apoptosis.
[Cell Death & Disease]
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Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
Cheng, J., Lin, M., Chu, M., Gong, L., Bi, Y., & Zhao, Y. (2020). Emerging role of FBXO22 in carcinogenesis. Cell Death Discovery, 6(1), 1–7. https://doi.org/10.1038/s41420-020-00303-0 Cite
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Pluripotent Stem Cells Reveal Poly-Unsaturated Fatty Acids-provoked Mitochondrial Stress as a Central Node Potentiating Retinal Pigmented Epithelium Degeneration in Bietti’s Crystalline Dystrophy

Using CYP4V2 mutant PSCs as disease models, scientists demonstrated that retinal pigmented epithelial cells with CYP4V2 mutations presented a disrupted fatty acid homeostasis, which were characterized with excessive accumulation of poly-unsaturated fatty acid.
[Molecular Therapy]
Zhang, Z., Yan, B., Gao, F., Li, Q., Meng, X., Chen, P., Zhou, L., Deng, W., Li, C., Xu, W., Han, S., Feng, H., Li, Y., Chen, J., Yin, Z., Liao, C., Tse, H.-F., Xu, A., & Lian, Q. (2020). Pluripotent Stem Cells Reveal Poly-unsaturated Fatty Acids-provoked Mitochondrial Stress as a Central Node Potentiating Retinal Pigmented Epithelium Degeneration in Bietti’s Crystalline Dystrophy. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2020.07.024 Cite
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Ascentage Pharma Announces First Patient Dosed in the Phase Ib Study of MDM2-p53 Inhibitor APG-115 as Single Agent and in Combinations for the Treatment of Hematologic Malignancies in China

Ascentage Pharma announced that the Phase Ib study of the company’s novel MDM2-p53 inhibitor candidate APG-115 as a single agent or in combinations for the treatment of Chinese patients with relapsed/refractory acute myeloid leukemia, or relapsed/progressed high/very high risk myelodysplastic syndrome has dosed its first patient in China.
[Ascentage Pharma]
Press Release

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Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of FBXO22 in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
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