pAkt

[Plant Foods For Human Nutrition] Investigators studied the metabolic effect of resveratrol around the circadian clock in order to determine more accurately the hepatic signaling pathways involved. AML-12 hepatocytes were treated with resveratrol and clock and metabolic markers were measured around the clock.

[Oncogene] Investigators analyzed the underlying molecular pathway and revealed that supraphysiological androgen levels induced cellular senescence in both, castration-sensitive LNCaP and castration-resistant prostate cancer C4-2 cells through the cell cycle inhibitor p15INK4b and increased phosphorylation of AKT.

[Scientific Reports] To investigate how AHA1 expression regulated the cancer cell progression and/or metastasis of human colorectal cancer (CRC), the expression levels of AHA1 and Hsp90 were examined in 105 CRC tissue samples and compared with those in paired normal tissue.

[FEBS Journal] Scientists examined liquid culture cancer spheroids for the acquisition of apical‐basal polarity, sensitivity to an Akt inhibitor and interaction with extracellular matrix.

[Cellular Oncology] Scientists investigated the expression of non-SMAD-transforming growth factor-beta (TGF-β) signaling proteins patient-derived tissues, cell lines and an immunocompetent mouse model.

[Nutrition and Cancer] Scientists investigated whether fucoxanthinol (FxOH), induced apoptosis in human pancreatic cancer cells. FxOH significantly promoted the growth of human pancreatic cancer PANC-1 cells.