Subramani, R., Medel, J., Flores, K., Perry, C., Galvez, A., Sandoval, M., Rivera, S., Pedroza, D. A., Penner, E., Chitti, M., & Lakshmanaswamy, R. (2020). Hepatocyte nuclear factor 1 alpha influences pancreatic cancer growth and metastasis. Scientific Reports, 10(1), 20225. https://doi.org/10.1038/s41598-020-77287-5Cite
Using several human and mouse models of PDACs, scientists demonstrated rapid acquisition of tumor resistance in response to targeting KRAS or MEK, associated with integrin-linked kinase-mediated increased phosphorylation of the mTORC2 component Rictor, and AKT.
Brown, W. S., McDonald, P. C., Nemirovsky, O., Awrey, S., Chafe, S. C., Schaeffer, D. F., Li, J., Renouf, D. J., Stanger, B. Z., & Dedhar, S. (2020). Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer. Cell Reports Medicine, 1(8). https://doi.org/10.1016/j.xcrm.2020.100131Cite
Sastry, K. S., Ibrahim, W. N., & Chouchane, A. I. (n.d.). Multiple signaling pathways converge on proapoptotic protein BAD to promote survival of melanocytes. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202001260RRCite
pigallocatechin-3-gallate (EGCG) induced an internal Ca2+ increase in prostate cancer (PCa) cells by a multi-step mechanism. Researchers confirmed the possibility of using EGCG as a synergistic adjuvant in combined therapies for recalcitrant malignancies like androgen-independent PCa.
Marchetti, C., Gavazzo, P., & Burlando, B. (2020). Epigallocatechin-3-gallate mobilizes intracellular Ca2+ in prostate cancer cells through combined Ca2+ entry and Ca2+-induced Ca2+ release. Life Sciences, 258, 118232. https://doi.org/10.1016/j.lfs.2020.118232Cite
Investigators showed the tumor-promoting function of a cell cycle-related protein, PIERCE1, in KRAS-mutant non-small cell lung cancer. Mechanistically, PIERCE1 depletion inhibited cell growth and AKT phosphorylation at S473, which was particularly observed in KRAS-mutant lung cancers.