Hepatocyte Nuclear Factor 1 Alpha Influences Pancreatic Cancer Growth and Metastasis

Silencing HNF1α reduced the proliferative, migratory, invasive and colony forming capabilities of pancreatic cancer cells.
[Scientific Reports]
Subramani, R., Medel, J., Flores, K., Perry, C., Galvez, A., Sandoval, M., Rivera, S., Pedroza, D. A., Penner, E., Chitti, M., & Lakshmanaswamy, R. (2020). Hepatocyte nuclear factor 1 alpha influences pancreatic cancer growth and metastasis. Scientific Reports, 10(1), 20225. https://doi.org/10.1038/s41598-020-77287-5 Cite
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Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-Targeting mTORC1/2 Complexes in Pancreatic Cancer

Using several human and mouse models of PDACs, scientists demonstrated rapid acquisition of tumor resistance in response to targeting KRAS or MEK, associated with integrin-linked kinase-mediated increased phosphorylation of the mTORC2 component Rictor, and AKT.
[Cell Reports Medicine]
Brown, W. S., McDonald, P. C., Nemirovsky, O., Awrey, S., Chafe, S. C., Schaeffer, D. F., Li, J., Renouf, D. J., Stanger, B. Z., & Dedhar, S. (2020). Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer. Cell Reports Medicine, 1(8). https://doi.org/10.1016/j.xcrm.2020.100131 Cite
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Multiple Signaling Pathways Converge on Proapoptotic Protein BAD to Promote Survival of Melanocytes

The authors showed that melanocyte survival was mediated by diverse, nonredundant signaling pathways, including ERK1/2, AKT, PKA, and PKC.
[FASEB Journal]
Sastry, K. S., Ibrahim, W. N., & Chouchane, A. I. (n.d.). Multiple signaling pathways converge on proapoptotic protein BAD to promote survival of melanocytes. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202001260RR Cite
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Overactivated Sonic Hedgehog Signaling Aggravates Intrauterine Adhesion via Inhibiting Autophagy in Endometrial Stromal Cells

Scientists report that impaired autophagy participated in sonic hedgehog signaling pathway-induced endometrial fibrosis.
[Cell Death & Disease]
Wei, C., Pan, Y., Zhang, Y., Dai, Y., Jiang, L., Shi, L., Yang, W., Xu, S., Zhang, Y., Xu, W., Zhang, Y., Lin, X., & Zhang, S. (2020). Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells. Cell Death & Disease, 11(9), 1–15. https://doi.org/10.1038/s41419-020-02956-2 Cite
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Cellular Retinol Binding Protein 1 Transfection Reduces Proliferation and AKT-Related Gene Expression in H460 Non-Small Lung Cancer Cells

Scientists investigated the effect of cellular retinol binding protein-1 (CRBP-1) transfection in the H460 human non-small cell lung cancer cell line, normally not expressing CRBP-1.
[Molecular Biology Reports]
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Epigallocatechin-3-Gallate Mobilizes Intracellular Ca2+ in Prostate Cancer Cells through Combined Ca2+ Entry and Ca2+-Induced Ca2+ Release

pigallocatechin-3-gallate (EGCG) induced an internal Ca2+ increase in prostate cancer (PCa) cells by a multi-step mechanism. Researchers confirmed the possibility of using EGCG as a synergistic adjuvant in combined therapies for recalcitrant malignancies like androgen-independent PCa.
[Life Sciences]
Marchetti, C., Gavazzo, P., & Burlando, B. (2020). Epigallocatechin-3-gallate mobilizes intracellular Ca2+ in prostate cancer cells through combined Ca2+ entry and Ca2+-induced Ca2+ release. Life Sciences, 258, 118232. https://doi.org/10.1016/j.lfs.2020.118232 Cite
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Impaired AKT Signaling and Lung Tumorigenesis by PIERCE1 Ablation in KRAS-Mutant Non-Small Cell Lung Cancer

Investigators showed the tumor-promoting function of a cell cycle-related protein, PIERCE1, in KRAS-mutant non-small cell lung cancer. Mechanistically, PIERCE1 depletion inhibited cell growth and AKT phosphorylation at S473, which was particularly observed in KRAS-mutant lung cancers.
[Oncogene]
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