Scientists investigated whether fucoxanthinol (FxOH), induced apoptosis in human pancreatic cancer cells. FxOH significantly promoted the growth of human pancreatic cancer PANC-1 cells.
[Nutrition and Cancer]
6807162 63GN5FT9 items 1 apa 0 default asc 1 159333 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-86d96740c3df5e837cf1f413facbcdcc%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2263GN5FT9%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Terasaki%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-16%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ETerasaki%2C%20M.%2C%20Takahashi%2C%20S.%2C%20Nishimura%2C%20R.%2C%20Kubota%2C%20A.%2C%20Kojima%2C%20H.%2C%20Ohta%2C%20T.%2C%20Hamada%2C%20J.%2C%20Kuramitsu%2C%20Y.%2C%20Maeda%2C%20H.%2C%20Miyashita%2C%20K.%2C%20Takahashi%2C%20M.%2C%20%26amp%3B%20Mutoh%2C%20M.%20%282021%29.%20A%20Marine%20Carotenoid%20of%20Fucoxanthinol%20Accelerates%20the%20Growth%20of%20Human%20Pancreatic%20Cancer%20PANC-1%20Cells.%20%3Ci%3ENutrition%20and%20Cancer%3C%5C%2Fi%3E%2C%20%3Ci%3E0%3C%5C%2Fi%3E%280%29%2C%201%26%23x2013%3B16.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F01635581.2020.1863994%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F01635581.2020.1863994%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3D63GN5FT9%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20Marine%20Carotenoid%20of%20Fucoxanthinol%20Accelerates%20the%20Growth%20of%20Human%20Pancreatic%20Cancer%20PANC-1%20Cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masaru%22%2C%22lastName%22%3A%22Terasaki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shouta%22%2C%22lastName%22%3A%22Takahashi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryuta%22%2C%22lastName%22%3A%22Nishimura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Atsuhito%22%2C%22lastName%22%3A%22Kubota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hiroyuki%22%2C%22lastName%22%3A%22Kojima%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tohru%22%2C%22lastName%22%3A%22Ohta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junichi%22%2C%22lastName%22%3A%22Hamada%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasuhiro%22%2C%22lastName%22%3A%22Kuramitsu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hayato%22%2C%22lastName%22%3A%22Maeda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kazuo%22%2C%22lastName%22%3A%22Miyashita%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mami%22%2C%22lastName%22%3A%22Takahashi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michihiro%22%2C%22lastName%22%3A%22Mutoh%22%7D%5D%2C%22abstractNote%22%3A%22Fucoxanthin%20and%20its%20metabolite%20fucoxanthinol%20%28FxOH%29%2C%20highly%20polar%20xanthophylls%2C%20exert%20strong%20anticancer%20effects%20against%20many%20cancer%20cell%20types.%20However%2C%20the%20effects%20of%20Fx%20and%20FxOH%20on%20pancreatic%20cancer%2C%20a%20high%20mortality%20cancer%2C%20remain%20unclear.%20We%20herein%20investigated%20whether%20FxOH%20induces%20apoptosis%20in%20human%20pancreatic%20cancer%20cells.%20FxOH%20%285.0%20%5Cu03bcmol%5C%2FL%29%20significantly%20promoted%20the%20growth%20of%20human%20pancreatic%20cancer%20PANC-1%20cells%2C%20but%20induced%20apoptosis%20in%20human%20colorectal%20cancer%20DLD-1%20cells.%20A%20microarray-based%20gene%20analysis%20revealed%20that%20the%20gene%20sets%20of%20cell%20cycle%2C%20adhesion%2C%20PI3K%5C%2FAKT%2C%20MAPK%2C%20NRF2%2C%20adipogenesis%2C%20TGF-%5Cu03b2%2C%20STAT%2C%20and%20Wnt%20signals%20in%20PANC-1%20cells%20were%20markedly%20altered%20by%20FxOH.%20A%20western%20blot%20analysis%20showed%20that%20FxOH%20up-regulated%20the%20expression%20of%20integrin%20%5Cu03b21%20and%20PPAR%5Cu03b3%20as%20well%20as%20the%20activation%20of%20pFAK%28Tyr397%29%2C%20pPaxillin%28Tyr31%29%2C%20and%20pAKT%28Ser473%29%20in%20PANC-1%20cells%2C%20but%20exerted%20the%20opposite%20effects%20in%20DLD-1%20cells.%20Moreover%2C%20the%20expression%20of%20FYN%2C%20a%20downstream%20target%20of%20integrin%20subunits%2C%20was%20up-regulated%20%287.4-fold%20by%20qPCR%29%20in%20FxOH-treated%20PANC-1%20cells.%20These%20results%20suggest%20that%20FxOH%20accelerates%20the%20growth%20of%20PANC-1%20cells%20by%20up-regulating%20the%20expression%20of%20integrin%20%5Cu03b21%2C%20FAK%2C%20Paxillin%2C%20FYN%2C%20AKT%2C%20and%20PPAR%5Cu03b3.%22%2C%22date%22%3A%22February%2016%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1080%5C%2F01635581.2020.1863994%22%2C%22ISSN%22%3A%220163-5581%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F01635581.2020.1863994%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-02-23T17%3A49%3A06Z%22%7D%7D%5D%7D
Terasaki, M., Takahashi, S., Nishimura, R., Kubota, A., Kojima, H., Ohta, T., Hamada, J., Kuramitsu, Y., Maeda, H., Miyashita, K., Takahashi, M., & Mutoh, M. (2021). A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells. Nutrition and Cancer, 0(0), 1–16. https://doi.org/10.1080/01635581.2020.1863994 Cite