Tag Archives: western blot analysis

Continue reading “Long Non-Coding RNA SNHG6 Regulates the Sensitivity of Prostate Cancer Cells to Paclitaxel by Sponging miR-186”

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Role of Sirtuin-1 (SIRT1) in Hypoxic Injury in Pancreatic β-Cells

Hypoxic damage significantly increased the TNF-α, IL-6 and ROS levels in INS-1 cells. However, the reduced cell viability and increased inflammatory cytokines from hypoxic damage were ameliorated by SIRT1 activation in INS-1 cells.

[Journal of Drug Targeting]

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Continue reading “Chelerythrine Suppresses Proliferation and Metastasis of Human Prostate Cancer Cells via Modulating MMP/TIMP/NF-κB System”

Chelerythrine Suppresses Proliferation and Metastasis of Human Prostate Cancer Cells via Modulating MMP/TIMP/NF-κB System

The addition of chelerythrine significantly inhibited the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 μM, but not on androgen-dependent prostate cancer LNCaP cells as well as normal prostate epithelial cell line PrEC cells.

[Molecular and Cellular Biochemistry]

Abstract

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Mesenchymal Stem Cells‐Derived and siRNAs‐Encapsulated Exosomes Inhibit Osteonecrosis of the Femoral Head

The authors explored the role of bone mesenchymal stem cells‐derived and siRNAs‐encapsulated exosomes in osteonecrosis of the femoral head.

[Journal of Cellular and Molecular Medicine]

Continue reading “Mesenchymal Stem Cells‐Derived and siRNAs‐Encapsulated Exosomes Inhibit Osteonecrosis of the Femoral Head”

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Cleavage of Proteoglycans, Plasma Proteins and the Platelet-Derived Growth Factor Receptor in the Hemorrhagic Process Induced by Snake Venom Metalloproteinases

The authors outlined the multifactorial character of snake venom metalloproteinases (SVMP)-induced tissue damage, including the transient activation of tissue proteinases, and underscored for the first time that endothelial glycocalyx proteoglycans and PDGFR were targets of SVMPs in the disruption of microvasculature integrity and generation of hemorrhage.

[Scientific Reports]

Continue reading “Cleavage of Proteoglycans, Plasma Proteins and the Platelet-Derived Growth Factor Receptor in the Hemorrhagic Process Induced by Snake Venom Metalloproteinases”

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Continue reading “miR-20a-5p Promotes Pulmonary Artery Smooth Muscle Cell Proliferation and Migration by Targeting ABCA1”

miR-20a-5p Promotes Pulmonary Artery Smooth Muscle Cell Proliferation and Migration by Targeting ABCA1

Reverse transcription polymerase chain reaction was employed to detect miR‐20a‐5p and ATP‐binding cassette subfamily A member 1 messenger RNA expression.

[Journal of Biochemical and Molecular Toxicology]

Abstract

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Transplantation of R-GSIK Scaffold with Mesenchymal Stem Cells Improves Neuroinflammation in a Traumatic Brain Injury Model

Investigators determined the ability of the R-GSIK scaffold in supporting the effects of mesenchymal stem cells on motor function activity and inflammatory responses in an experimental traumatic brain injury model.

[Cell and Tissue Research]

Continue reading “Transplantation of R-GSIK Scaffold with Mesenchymal Stem Cells Improves Neuroinflammation in a Traumatic Brain Injury Model”