KDM3B-ETF1 Fusion Gene Downregulates LMO2 via the WNT/β-Catenin Signaling Pathway, Promoting Metastasis of Invasive Ductal Carcinoma

Scientists investigated the possible effects KDM3B-ETF1 fusion gene had on breast cancer cell metastasis, invasion and its downstream signaling mediators as revealed from RNA sequence data analysis.
[Cancer Gene Therapy]
Hu, A., Hong, F., Li, D., Xie, Q., Chen, K., Zhu, L., & He, H. (2021). KDM3B-ETF1 fusion gene downregulates LMO2 via the WNT/β-catenin signaling pathway, promoting metastasis of invasive ductal carcinoma. Cancer Gene Therapy, 1–10. https://doi.org/10.1038/s41417-021-00301-z Cite
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Antibody–Drug Nanoparticle Induces Synergistic Treatment Efficacies in HER2 Positive Breast Cancer Cells

Antibody–drug nanoparticles were engineered by synthesizing pure anti-cancer drug nanorods in the core of nanoparticles with a therapeutic monoclonal antibody, Trastuzumab on the surface of NRs for specific targeting and synergistic treatments of human epidermal growth factor receptor 2 positive breast cancer cells.
[Scientific Reports]
Abedin, M. R., Powers, K., Aiardo, R., Barua, D., & Barua, S. (2021). Antibody–drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells. Scientific Reports, 11(1), 7347. https://doi.org/10.1038/s41598-021-86762-6 Cite
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Lyophilized Powder of Mesenchymal Stem Cell Supernatant Attenuates Acute Lung Injury through the IL-6–P-STAT3–p63–JAG2 Pathway

Intratracheal bleomycin was used to induce acute lung injury in mice, and intratracheal MSCs in a supernatant lyophilized powder was administered as a treatment.
[Stem Cell Research & Therapy]
Peng, W., Chang, M., Wu, Y., Zhu, W., Tong, L., Zhang, G., Wang, Q., Liu, J., Zhu, X., Cheng, T., Li, Y., Chen, X., Weng, D., Liu, S., Zhang, H., Su, Y., Zhou, J., Li, H., & Song, Y. (2021). Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6–p-STAT3–p63–JAG2 pathway. Stem Cell Research & Therapy, 12(1), 216. https://doi.org/10.1186/s13287-021-02276-y Cite
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Chitosan Hydrogel-Loaded MSC-Derived Extracellular Vesicles Promote Skin Rejuvenation by Ameliorating the Senescence of Dermal Fibroblasts

Chitosan (CS) hydrogel-encapsulated extracellular vesicles could delay the skin aging processes by ameliorating the function of aging dermal fibroblasts. The results also highlighted the potential of CS hydrogel-encapsulated extracellular vesicles as a novel therapeutic strategy for improving aging skin to rejuvenation.
[Stem Cell Research & Therapy]
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Vinculin Orchestrates Prostate Cancer Progression by Regulating Tumor Cell Invasion, Migration, and Proliferation

Researchers investigated the potential role of vinculin in prostate cancer progression in vitro and in vivo.
[Prostate]
Zheng, X., Xu, H., Gong, L., Cao, D., Jin, T., Wang, Y., Pi, J., Yang, Y., Yi, X., Liao, D., Jin, X., Wei, Q., Yang, L., Li, H., & Ai, J. (n.d.). Vinculin orchestrates prostate cancer progression by regulating tumor cell invasion, migration, and proliferation. The Prostate, n/a(n/a). https://doi.org/https://doi.org/10.1002/pros.24113 Cite
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RAF-Mutant Melanomas Differentially Depend on ERK2 over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

Investigators demonstrated that ERK2 drove BRAF-mutant melanoma gene expression and proliferation as a function of its higher expression compared to ERK1.
[Molecular Cancer Research]
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BASP1 Labels Neural Stem Cells in the Neurogenic Niches of Mammalian Brain

Researchers describe the expression of brain abundant, membrane-attached signal protein 1 (BASP1), in neural stem cells (NSCs) in the developing and postnatal mammalian brains and human brain organoids, and demonstrated that the NSC-6 antibody may be a useful marker of these cells.
[Scientific Reports]
Manganas, L. N., Durá, I., Osenberg, S., Semerci, F., Tosun, M., Mishra, R., Parkitny, L., Encinas, J. M., & Maletic-Savatic, M. (2021). BASP1 labels neural stem cells in the neurogenic niches of mammalian brain. Scientific Reports, 11(1), 5546. https://doi.org/10.1038/s41598-021-85129-1 Cite
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EGFL7 as a Novel Therapeutic Candidate Regulates Cell Invasion and Anoikis in Colorectal Cancer through PI3K/AKT Signaling Pathway

Epidermal growth factor-like domain-containing protein 7 (EGFL7) was upregulated in several colorectal cancer cell lines as compared with normal intestinal epithelial cell line HIEC. Transfection of EGFL7 siRNA significantly decreased cell proliferation and invasion capacity of SW620 and LoVo cells.
[International Journal of Clinical Oncology]
Juan, Z., Dake, C., Tanaka, K., & Shuixiang, H. (2021). EGFL7 as a novel therapeutic candidate regulates cell invasion and anoikis in colorectal cancer through PI3K/AKT signaling pathway. International Journal of Clinical Oncology. https://doi.org/10.1007/s10147-021-01888-x Cite
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CircVAPA Exerts Oncogenic Property in Non‐Small Cell Lung Cancer by the miR‐876‐5p/WNT5A Axis

RT‐qPCR was used to measure the expression of genes. Actinomycin D and RNase R were employed to examine the stability of circVAPA. CCK‐8, EdU, Transwell, sphere formation assay, and western blot analysis were conducted to examine the changes of NSCLC cells in response to circVAPA knockdown. Luciferase reporter assay was conducted for molecular mechanism.
[Journal of Gene Medicine]
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A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells

Scientists investigated whether fucoxanthinol (FxOH), induced apoptosis in human pancreatic cancer cells. FxOH significantly promoted the growth of human pancreatic cancer PANC-1 cells.
[Nutrition and Cancer]
Terasaki, M., Takahashi, S., Nishimura, R., Kubota, A., Kojima, H., Ohta, T., Hamada, J., Kuramitsu, Y., Maeda, H., Miyashita, K., Takahashi, M., & Mutoh, M. (2021). A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells. Nutrition and Cancer, 0(0), 1–16. https://doi.org/10.1080/01635581.2020.1863994 Cite
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Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling

Scientists investigated the effects of high glucose on the innate immunity of podocytes and diabetic nephropathy mice via Toll like receptor (TLR) signaling, and explored the protective effects of human umbilical cord-MSCs on this process.
[Diabetes Research and Clinical Practice]
Wang, Y., Liu, J., Zhang, Q., Wang, W., Liu, Q., Liu, S., Song, Y., Wang, X., Zhang, Y., Li, S., Yang, X., Lv, S., & Liu, G. (2021). Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling. Diabetes Research and Clinical Practice, 0(0). https://doi.org/10.1016/j.diabres.2021.108702 Cite
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