Molecular Expression and Functional Features of Kv7 Channels in Human Prostate Smooth Muscle

In human prostatic smooth muscle cells, KCNQ4, KCNQ5, and KCNE4 isoforms were predominantly expressed, while KCNQ1, KCNQ5, and KCNE3 isoforms were the most abundantly expressed in human prostatic tissues.
[Andrology]
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Restored MicroRNA-519a Enhances the Radiosensitivity of Non-Small Cell Lung Cancer via Suppressing EphA2

Researchers investigated the role of miR-519a-targeted ephrinA2 receptor in radiosensitivity of NSCLC. miR-519a and EphA2 expression in non-small cell lung cancer and paracancerous tissues were detected using RT-qPCR and western blot analysis.
[Gene Therapy]
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Proteomic Analysis and Cell Viability of Nine Amnion, Chorion, Umbilical Cord, and Amniotic Fluid–Derived Products

Investigators determined the full proteome and examine cell viability in nine commercial amnion products using an unbiased bottom-up shotgun proteomics approach and confocal microscopy.
[Cartilage]
Becktell, L., Matuska, A. M., Hon, S., Delco, M. L., Cole, B. J., Begum, L., Zhang, S., & Fortier, L. A. (2020). Proteomic Analysis and Cell Viability of Nine Amnion, Chorion, Umbilical Cord, and Amniotic Fluid–Derived Products. CARTILAGE, 1947603520976767. https://doi.org/10.1177/1947603520976767 Cite
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YY1-Mediated Long Non-Coding RNA Kcnq1ot1 Promotes the Tumor Progression by Regulating PTEN via DNMT1 in Triple Negative Breast Cancer

The authors identified the roles of YY1-mediated long non-coding RNA Kcnq1ot1 in TNBC.
[Cancer Gene Therapy]
Shen, B., Li, Y., Ye, Q., & Qin, Y. (2020). YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-020-00254-9 Cite
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Involvement of CDK11B-Mediated SPDEF Ubiquitination and SPDEF-Mediated MicroRNA-448 Activation in the Oncogenicity and Self-Renewal of Hepatocellular Carcinoma Stem Cells

Investigators characterized the aberrant upregulation of CDK11B and downregulation SAM pointed domain-containing ETS transcription factor (SPDEF) in hepatocellular carcinoma tissues and cells.
[Cancer Gene Therapy]
Guo, J., Yang, Y., Guo, M., Zhang, J., Zheng, J., & Liu, Z. (2020). Involvement of CDK11B-mediated SPDEF ubiquitination and SPDEF-mediated microRNA-448 activation in the oncogenicity and self-renewal of hepatocellular carcinoma stem cells. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-020-00261-w Cite
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Integrin α2β1 Inhibition Attenuates Prostate Cancer Cell Proliferation by Cell Cycle Arrest, Promoting Apoptosis and Reducing Epithelial-Mesenchymal Transition

Investigators examined the effects of the inhibitor BTT‐3033, which selectively interferes with the connection between integrin a2b1 and its ligand, on migration, epithelial–mesenchymal transition, cell cycle arrest, apoptosis, and specific intracellular signaling pathways using LNcap‐FGC and DU‐145 prostate cancer cell lines.
[Journal of Cellular Physiology]
Salemi, Z., Azizi, R., Fallahian, F., & Aghaei, M. (n.d.). Integrin α2β1 inhibition attenuates prostate cancer cell proliferation by cell cycle arrest, promoting apoptosis and reducing epithelial–mesenchymal transition. Journal of Cellular Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcp.30202 Cite
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ATF-3 Expression Inhibits Melanoma Growth by Downregulating ERK and AKT Pathways

Investigators demonstrated that activating transcription factor 3 (ATF-3) exhibits tumor suppressive function in melanoma. Significantly low expression of ATF-3 was found in cultured human metastatic melanoma cell lines.
[Laboratory Investigation]
Zu, T., Wang, D., Xu, S., Lee, C. A. A., Zhen, E., Yoon, C. H., Abarzua, P., Wang, S., Frank, N. Y., Wu, X., Lian, C. G., & Murphy, G. F. (2020). ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways. Laboratory Investigation, 1–12. https://doi.org/10.1038/s41374-020-00516-y Cite
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The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway

The anti-cancer mechanism of Isoquercitrin (IQ) against human melanoma, particularly its effect on the mitochondria-mediated apoptosis, was investigated. Treatment with IQ at 25 μM concentration effectively inhibited the proliferation of SK-MEL-2 skin cancer cells while the same concentration did not exhibit cytotoxicity against human keratinocytes HaCaT.
[Nutrients]
Won, Y.-S., Kim, J.-H., Lizardo, R. C. M., Min, H.-J., Cho, H.-D., Hong, S.-M., & Seo, K.-I. (2020). The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway. Nutrients, 12(12), 3683. https://doi.org/10.3390/nu12123683 Cite
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Human Placenta-Derived Mesenchymal Stem Cells Stimulate Ovarian Function via miR-145 and Bone Morphogenetic Protein Signaling in Aged Rats

Acclimatized 52-week-old female SD rats were randomly divided into four groups: single human placenta derived (hPD)-MSC therapy, multiple hPD-MSC therapy, control, and non-treated groups. hPD-MSC therapy was conducted by tail vein injection into aged rats.
[Stem Cell Research & Therapy]
Kim, K.-H., Kim, E.-Y., Kim, G. J., Ko, J.-J., Cha, K. Y., Koong, M. K., & Lee, K.-A. (2020). Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats. Stem Cell Research & Therapy, 11(1), 472. https://doi.org/10.1186/s13287-020-01988-x Cite
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Optimizing Microenvironment by Integrating Negative Pressure and Exogenous Electric Fields via a Flexible Porous Conductive Dressing to Accelerate Wound Healing

Current treatments for nonhealing or chronic wounds were unsatisfactory as they exerted a single effect on one specific activity. Researchers constructed a silver nanowire-based, three-dimensional, porous foam dressing that is flexible and conductive.
[Biomaterials Science]
Chen, Y., Liang, Y., Liu, J., Yang, J., Jia, N., Zhu, C., & Zhang, J. (2020). Optimizing microenvironment by integrating negative pressure and exogenous electric fields via a flexible porous conductive dressing to accelerate wound healing. Biomaterials Science. https://doi.org/10.1039/D0BM01172J Cite
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In Vitro and In Vivo BNCT Investigations Using a Carborane Containing Sulfonamide Targeting CAIX Epitopes on Malignant Pleural Mesothelioma and Breast Cancer Cells

Scientists merged the therapeutic effects associated to the inhibition of Carbonic Anhydrase IX (CAIX), an essential enzyme overexpressed by cancer cells including mesothelioma and breast cancer, with those ones brought by the application of Boron Neutron Capture Therapy (BNCT).
[Scientific Reports]
Alberti, D., Michelotti, A., Lanfranco, A., Protti, N., Altieri, S., Deagostino, A., & Geninatti Crich, S. (2020). In vitro and in vivo BNCT investigations using a carborane containing sulfonamide targeting CAIX epitopes on malignant pleural mesothelioma and breast cancer cells. Scientific Reports, 10(1), 19274. https://doi.org/10.1038/s41598-020-76370-1 Cite
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