Investigators observed that plasmacytoma variant translocation 1 (PVT1) and caspase‐10 were upregulated while miR‐23a‐3p was downregulated in high glucose‐induced cardiomyocytes. High glucose repressed cardiomyocyte activity and induced cardiomyocyte apoptosis, but this influence was antagonized by PVT1 knockdown or miR‐23a‐3p overexpression.
[Cell Biology International]
Scientists demonstrated that the expression of FOXC1 was associated with resistance of doxorubicin treatment of breast cancer cells.
[Acta Pharmacologica Sinica]
Scientists examined the effects of evogliptin, a potent DPP-4 inhibitor, on pathological retinal neovascularization in mice and elucidated the mechanism by which evogliptin inhibits angiogenesis mediated by VEGF, a key factor in the vascular pathogenesis of proliferative diabetic retinopathy
[Experimental and Molecular Medicine]
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Seo, S., Kim, M.-K., Kim, R.-I., Yeo, Y., Kim, K. L., & Suh, W. (2020). Evogliptin, a dipeptidyl peptidase-4 inhibitor, attenuates pathological retinal angiogenesis by suppressing vascular endothelial growth factor-induced Arf6 activation. Experimental & Molecular Medicine, 1–10. https://doi.org/10.1038/s12276-020-00512-8 Cite
Investigators generated a mouse model with pancreas-specific deletion of PKD3, the predominant PKD isoform in mouse pancreatic acinar cells, by crossing Pkd3flox/flox mice with Pdx1-Cre transgenic mice which express Cre recombinase under the control of the mouse Pdx1 promoter.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
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Yuan, J., Chheda, C., Piplani, H., Geng, M., Tan, G., Thakur, R., & Pandol, S. J. (2020). Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 165987. https://doi.org/10.1016/j.bbadis.2020.165987 Cite
Scientists explored whether p53 played a crucial role in the senescence of activated hepatic stellate cells and degradation of collagen mediated by interleukin-10.
[Experimental Biology and Medicine]
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Scientists recognized the tumor suppressor gene Phosphatase and Tensin homolog (PTEN) as a potential gene causing CIN in TNBC and showed that TNBC with low expression levels of PTEN can be sensitized for the treatment with poly-(ADP-ribose)-polymerase 1 (PARP1) inhibitors, independent of Breast Cancer (BRCA) mutations or a BRCA-like phenotype.
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Rieckhoff, J., Meyer, F., Classen, S., Zielinski, A., Riepen, B., Wikman, H., Petersen, C., Rothkamm, K., Borgmann, K., & Parplys, A. C. (2020). Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner. Cancers, 12(10), 2809. https://doi.org/10.3390/cancers12102809 Cite
LINC00665 expression levels were determined using quantitative polymerase chain reaction analysis with breast cancer tissues and cell lines.
[Cellular & Molecular Biology Letters]
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Lv, M., Mao, Q., Li, J., Qiao, J., Chen, X., & Luo, S. (2020). Knockdown of LINC00665 inhibits proliferation and invasion of breast cancer via competitive binding of miR-3619-5p and inhibition of catenin beta 1. Cellular & Molecular Biology Letters, 25(1), 43. https://doi.org/10.1186/s11658-020-00235-8 Cite
The authors identified a long noncoding RNA LINC00857 that might regulate radio-sensitivity of lung adenocarcinoma cells.
[Molecular Therapy-Nucleic Acids]
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Investigators used tandem mass tag labeling technology followed by tandem mass spectrometry to compare the peptidomic profile of preterm and term umbilical cord MSC conditioned medium.
[Stem Cell Research & Therapy]
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Wang, Y., Zhang, L., Wu, Y., Zhu, R., Wang, Y., Cao, Y., Long, W., Ji, C., Wang, H., & You, L. (2020). Peptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants. Stem Cell Research & Therapy, 11(1), 414. https://doi.org/10.1186/s13287-020-01931-0 Cite
Scientists demonstrated new specific interactions of EMILINs with fibulins in the dentin enamel junction. In dentin caries lesions the signal for EMILIN-3 was significantly increased in inflamed odontoblasts.
A tumor xenograft mouse model was used to determine role of extracellular vesicles-microRNA-130b-3p and its target FOXO3 in lung cancer progression in vivo.
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Guo, Q., Yan, J., Song, T., Zhong, C., Kuang, J., Mo, Y., Tan, J., Li, D., Sui, Z., Cai, K., & Zhang, J. (2020). microRNA-130b-3p Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.09.005 Cite