ATF6α Promotes Prostate Cancer Progression by Enhancing PLA2G4A-Mediated Arachidonic Acid Metabolism and Protecting Tumor Cells against Ferroptosis

Researchers found that the increase of transcription factor 6 α (ATF6α) expression in response to androgen deprivation generated prostate cancer cells with a CRPC-like phenotype.
[Prostate]
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Tanshinone IIA Attenuates the Stemness of Breast Cancer Cells via Targeting the miR-125b/STARD13 Axis

In vitro mammary spheroid formation, flow cytometry assay on CD24−/CD44+ sub-population, ALDH activity detection, cell viability assay and western blot analysis, and in vivo tumor-initiating analysis were performed to examine the effects of Tanshinone IIA on the stemness of breast cancer cells.
[Experimental Hematology & Oncology]
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Antiproliferative and Proapoptotic Activities of Sea Cucumber H. Leucospilota Extract on Breast Carcinoma Cell Line (SK-BR-3)

H. leucospilota was collected, the methanolic extract was prepared and in vitro cytotoxicity of H. leucospilota extract in the range of 12.5, 25, 50, 100, and 200 μg/mL concentrations for 48 hours on SK-BR-3 and MCR5 cells was determined.
[Molecular Biology Reports]
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Caveolin-1 Alleviates Crohn’s Disease–Induced Intestinal Fibrosis by Inhibiting Fibroblasts Autophagy through Modulating Sequestosome 1

Human Crohn’s disease (CD) tissue samples were gained from patients with CD who underwent surgical resection of the intestine and were defined as stenotic or nonstenotic areas.
[Inflammatory Bowel Diseases]
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LncRNA UCA1 Promotes SOX12 Expression in Breast Cancer by Regulating m6A Modification of miR-375 by METTL14 through DNA Methylation

Researchers elucidated the underlying mechanism by which lncRNA UCA1 affected the m6A modification of miR-375 by mediating the DNA methylation of METTL14 and then altering SOX12 expression in breast cancer.
[Cancer Gene Therapy]
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Overexpression of miR-375 Reverses the Effects of Dexamethasone on the Viability, Migration, Invasion and Apoptosis of Human Airway Epithelial Cells by Targeting DUSP6

The altered expression of microRNAs has been found in asthma. However, the detailed mechanisms responsible for the effects of miR‑375 on Dex‑induced airway epithelial cell dysfunction remain elusive. Researchers elucidated these mechanisms.
[International Journal of Molecular Medicine]
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MicroRNA-149 Suppresses Osteogenic Differentiation of Mesenchymal Stem Cells via Inhibition of AKT1-Dependent Twist1 Phosphorylation

Scientists elucidated the role of miR-149 in osteogenic differentiation of MSCs and the underlying mechanism.
[Cell Death Discovery]
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Endothelial Cells Are an Important Source of BDNF in Rat Skeletal Muscle

Scientists provided a comprehensive analysis of BDNF localization in rat skeletal muscle.
[Scientific Reports]
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Ailanthone Suppresses the Activity of Human Colorectal Cancer Cells through the STAT3 Signaling Pathway

The authors investigated the antitumor effects of Ailanthone on HCT116 and SW620 colon cancer cells, and to analyze the underlying molecular mechanisms.
[International Journal of Molecular Medicine]
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STAT3 as a Target for Sensitizing Prostate Cancer Cells to Irradiation

Investigators demonstrated that STAT3 blockade with a STAT3 inhibitor or siRNA increased the radiosensitivity of prostate cancer (PCa) cells and that radiation together with STAT3 blockade induced more apoptosis and double-strand breaks than radiation alone in LNCaP cells.
[Radiation Research]
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CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-Small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44

The authors investigated the role of circular RNA F-box and WD repeat domain containing 8 (circFBXW8) in NSCLC progression and the underlying mechanism.
[Biochemical Genetics]
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