Researchers investigated the effects of bile acids on tissue factor activity and thrombin generation in hepatocytes and correlated these effects with activation of farnesoid X receptor-dependent signaling and apoptosis.
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Greimel, T., Jahnel, J., Pohl, S., Strini, T., Tischitz, M., Meier-Allard, N., Holasek, S., Meinel, K., Aguiriano-Moser, V., Zobel, J., Haidl, H., Gallistl, S., Panzitt, K., Wagner, M., & Schlagenhauf, A. (2021). Bile acid-induced tissue factor activity in hepatocytes correlates with activation of farnesoid X receptor. Laboratory Investigation, 1–9. https://doi.org/10.1038/s41374-021-00628-z Cite
Aberrant bone marrow-M1/M2 MФ polarization, characterized by increased M1 MФs and decreased M2 MФs and accompanied by impaired megakaryopoiesis-supporting abilities, was found in patients with thrombocytopenia post-allotransplant.
[Signal Transduction and Targeted Therapy]
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Using human vascular smooth muscle cells (VSMCs) treated by oxidized low-density lipoprotein to establish an atherosclerosis cell model, researchers explored the functional roles and molecular mechanisms of miR-141-5p in VSMCs dysfunction.
[Journal of Biochemical and Molecular Toxicology]
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Focal cerebral ischemia-reperfusion injury model and primary cortical neurons were established an oxygen-glucose deprivation injury model. Neuronal cell viability was determined by MTT assay. Western blot analysis was determined for protein expression.
[Brain and Behavior]
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The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.
[Molecular Therapy-Nucleic Acids]
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Sun, Z., Sun, D., Feng, Y., Zhang, B., Sun, P., Zhou, B., Du, L., Wang, Y., Fan, Z., Yang, J., Li, Y., Hu, S., & Zhan, H. (2021). Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.06.001 Cite
Researchers silenced Ndufs4 in Neuro-2a cells and we observed shorter neurite lengths with decreased expression of synaptophysin.
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Scientists investigated the effect of direct contact of prostate cancer (PCa) cells with mesenchymal stem cells on the stemness of PCa and its mechanisms.
[Cell and Bioscience]
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Alizarin red staining and quantification of calcium content showed that spermidine treatment markedly reduced mineral deposition in both rat and human vascular smooth muscle cells (VSMCs) under osteogenic conditions.
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The authors explored the specific role of solute carrier organic anion transporter family member 4A1-AS1 (SLCO4A1-AS1) in colon CSCs.
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Scientists studied the in vitro inhibitory properties of the tryptophan-derived endogenous metabolite kynurenic acid and of the lactam form of 3–2′-pyrrilonidinyl-kynurenic acid, alkaloids usually present in combination in chestnut honey in two castration-resistant prostate cancer cell lines.
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Investigators aimed to validate patient-specific iPSC-derived hepatocyte-like cells as an appropriate tool to model autosomal recessive hypercholesterolemia disease.
[Stem Cells and Development]
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Nikasa, M. P., Tricot, T., Mahdieh, D. N., Baharvand, D. H., Totonchi, M. M., Hejazi, D. M. S., & Verfaillie, D. C. M. (2021, May 2). Patient-Specific induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells as a Model to Study Autosomal Recessive Hypercholesterolemia [Research-article]. Https://Home.Liebertpub.Com/Scd. https://doi.org/10.1089/scd.2020.0199 Cite