pancreatic cancer cells

[Chemistry & Biodiversity] Geranyl-2,4-dihydroxy-6-phenethylbenzoate (GDP), isolated from Boesenbergia pandurata rhizomes, exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition starvation conditions.

[Molecular Therapy-Nucleic Acids] Scientists screened multi-layer molecular data of 36 pancreatic cancer cell lines, including gene mutation, gene expression, miRNA expression, and protein profiles.

[Cell Reports] Researchers determined that SRC-inhibitor-mediated suppression of p130Cas phosphorylation impaired MYC transcription through a DOCK1-RAC1-β-catenin-dependent mechanism.

[Cell Death & Differentiation] Scientists demonstrated that SIRT1/CUL4B promoted CSC-like properties, including increased stemness marker expression and sphere formation.

[Biological Trace Element Research] Scientists found that EPCAM + tumors developed in the mouse pancreas store zinc that is detectable by fluorescence-activated cell sorting using N-(6-methoxy-8-quinolyl)-p-toluenesulfonamide (TSQ), a fluorescence chelator. EPCAM + TSQ + tumor cells isolated from the mouse pancreas formed organoids in matrigel.

[Nutrition and Cancer-An International Journal] Human pancreatic cancer cells MIA-Pa-Ca-2 were treated with the phytochemicals alone or their equimolar mixture for 24 h and activation of Nrf2 and expression of its target genes were evaluated.