pancreatic cancer cells

[Oncotarget] Researchers described the radiolabeling, in vitro and in vivo evaluation of a bi-terminally PEGylated A20FMDV2 conjugated with DOTA or PCTA for 64Cu radiolabeling.

[Biomedicine & Pharmacotherapy] Panc-1 and MiaPaCa-2 cells treated chronically with gemcitabine displayed increased transcription and expression of CSC-associated markers.

[Journal of Cellular and Molecular Medicine] Researchers proposed to construct an immune-related prognostic risk model based on immune-related genes MMP14 and INHBA expression that could assess the prognosis of pancreatic cancer patients and identify potential therapeutic targets for pancreatic cancer, to provide new ideas for the treatment of pancreatic cancer.

[Cell Death & Disease] Treatment of PDAC cells with AdipoRon led to mitochondrial uncoupling and loss of ATP production. Concomitantly, AdipoRon-treated cells increased glucose uptake and utilization.

[Cell Death & Disease] Niclosamide inhibited proliferation of pancreatic cancer cells, induced apoptosis via the mitochondrial-mediated pathway, and suppressed cell migration and invasion by antagonizing epithelial-to-mesenchymal transition.

[Oncogene] Scientists performed the molecular and histological assessment of patient-derived PanINs, tumor tissues and pancreas from mouse models with PDAC (KC mice that harbor K-RAS mutation in pancreatic tissue), where we noted marked upregulation of gastrokine (GKN) proteins.