pancreatic cancer cells

[Cancer Science] Scientists showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro and in vivo in two pancreatic cancer cell lines, KLM1 and KMP5.

[Oncology Reports] Researchers focused upon the effect of propofol on pancreatic cancer cells and the mechanism by which propofol reduced A disintegrin and metalloproteinase 8 (ADAM8) expression.

[Molecular Medicine Reports] RO 48‑8071 (RO) was used to treat the pancreatic cancer cell line in vitro to examine the effects of RO on cell viability, as well as to determine its potential molecular mechanism.

[Cell Death Discovery] Scientists performed RNA pull-down, cycloheximide-chase, and ubiquitination assays to determine the effect of SOX2OT on FUS ubiquitination, and explored the specific regulatory mechanism of SOX2OT–FUS axis in pancreatic cancer cell migration, invasion, in vivo tumor growth, and metastasis through RNA sequencing.

[Cell Death Discovery] Scientists identified the role and molecular mechanisms of ZFAS1 in pancreatic cancer. The expression of ZFAS1, miR-497-5p and HMGA2 in pancreatic cancer tissues was detected by qRT-PCR.

[Nature Materials] Experimental in vitro models that capture pathophysiological characteristics of human tumors are essential for basic and translational cancer biology. Researchers described a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.