pancreatic cancer

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed that SSEA-4 was more expressed in all pancreatic cancer cell lines examined but not detectable in normal pancreatic cells.

[ACS Omega] Researchers investigate the function of miR-199 on gemcitabine-resistance in pancreatic cancer, as well as the underlying mechanism.

[Nature Reviews Gastroenterology & Hepatology] Weight loss-induced decrease of intra-pancreatic fat is tightly associated with remission of type 2 diabetes mellitus and its re-deposition with recurrence of the disease.

[Journal of Physiology and Biochemistry] Scientists identified that a 3D co-culture model of MIA PaCa-2 or PANC-1 with cancer-associated fibroblasts showed an increased chemoresistance to gemcitabine when compared to standard 2D mono-cultures a difference to paclitaxel which showed no measurable difference between the 2D and 3D models, suggesting a complex interaction between the drug in study and the cell type used.

[Aging] The tumor-suppressive effects of puerarin were determined by both in vitro and in vivo assays. The effects of puerarin on the proliferation, apoptosis, migration and invasion of pancreatic cancer cells, and tumor growth and metastasis in pancreatic ductal adenocarcinoma xenograft mouse model were performed.

[Cellular Oncology] Scientists evaluated the expression and clinicopathological significance of sparc/osteonectin, cwcv and kazal-like domain proteoglycan 1 (SPOCK1) in primary pancreatic cancer (PC) specimens and explored the mechanisms underlying SPOCK1-mediated PC cell growth and metastasis.