pancreatic cancer

[Journal of Translational Medicine] Expression of long noncoding RNAs NORAD, miR-202-5p and ANP32E in pancreatic cancer tissues and cell lines was quantified after RNA isolation. Dual-luciferase reporter assay, RNA pull-down and RIP assays were performed to verify the interactions among NORAD, miR-202-5p and ANP32E.

[ACS Applied Materials & interfaces] Researchers utilized tetrahedral framework nucleic acids as vehicles to overcome the biological barriers for delivering small molecular RNAs and efficiently transferred two kinds of copper transporter (CTR1) mRNA-targeted RNA therapeutics, siCTR1 or miR-124, into PANC-1 cells.

[Molecular Medicine Reports] Sodium channel epithelial 1α subunit (SCNN1A) serves an important role in tumor progression. Scientists explored the role of homeobox D9 (HOXD9) and SCNN1A in the progression of pancreatic cancer.

[Cell Death Discovery] Scientists performed RNA pull-down, cycloheximide-chase, and ubiquitination assays to determine the effect of SOX2OT on FUS ubiquitination, and explored the specific regulatory mechanism of SOX2OT–FUS axis in pancreatic cancer cell migration, invasion, in vivo tumor growth, and metastasis through RNA sequencing.

[Cell Death Discovery] Scientists identified the role and molecular mechanisms of ZFAS1 in pancreatic cancer. The expression of ZFAS1, miR-497-5p and HMGA2 in pancreatic cancer tissues was detected by qRT-PCR.

[Journal of Cellular and Molecular Medicine] Long non-coding RNAs biological functions and molecular mechanisms associated with pancreatic cancer (PC) remain to be poorly elucidated. Researchers clarified the role of lncRNA LINC00261 in PC and confirmed its regulatory mechanisms.