pancreatic cells

[Cell Death & Disease] Niclosamide inhibited proliferation of pancreatic cancer cells, induced apoptosis via the mitochondrial-mediated pathway, and suppressed cell migration and invasion by antagonizing epithelial-to-mesenchymal transition.

[Cancer Cell] The authors showed that oncogenic KrasG12D increased IL-33 expression in PDAC cells, which recruited and activated TH2 and innate lymphoid cells 2 cells.

[Cell Metabolism] By screening the expression and functional characterization of olfactory receptors in pancreatic islets, investigators identified Olfr109 as the receptor that detects insulin peptides.

[Cell Reports] Researchers showed that the Rho effector protein kinase N2 (PKN2) was critical for pancreatic stellate cell (PSC) myofibroblast differentiation. Loss of PKN2 was associated with reduced PSC proliferation, contractility, and alpha-smooth muscle actin stress fibers.

[Cellular Signalling] Scientists investigated whether the lncRNA MEG3 could regulate autophagy and pyroptosis through FOXO1 in pancreatic β-cells.

[Oncogene] Scientists performed the molecular and histological assessment of patient-derived PanINs, tumor tissues and pancreas from mouse models with PDAC (KC mice that harbor K-RAS mutation in pancreatic tissue), where we noted marked upregulation of gastrokine (GKN) proteins.