Disruption of Pancreatic Stellate Cell Myofibroblast Phenotype Promotes Pancreatic Tumor Invasion

Researchers showed that the Rho effector protein kinase N2 (PKN2) was critical for pancreatic stellate cell (PSC) myofibroblast differentiation. Loss of PKN2 was associated with reduced PSC proliferation, contractility, and alpha-smooth muscle actin stress fibers.