pancreatic ductal adenocarcinoma

[Cancer Research] Investigators showed that the mitochondrial calcium uniporter promoted pancreatic ductal adenocarcinoma cell migration, invasion, metastasis, and metabolic stress resistance by activating the Keap1-Nrf2 antioxidant program.

[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.

[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.

[Matrix Biology] To identify the integrin adhesion systems that operate in PDAC, investigators analyzed a range of pancreatic ductal epithelial cell models using 2D, 3D and organoid culture systems.

[Journal of Experimental & Clinical Cancer Research] PDAC cells used a distinct and lengthy process of reversible adaptive plasticity centered on the early fast and later slow mitochondrial network dynamics and metabolic adjustment to microenvironmental acidification..

[Journal of Experimental & Clinical Cancer Research] Multiple bioinformatics analyses were used to evaluate zinc finger matrin-type 1 (ZMAT1) expression and potential role in PDAC.In vitro and in vivo studies were performed to assess the effects of ZMAT1 on PDAC cells growth.