Mutant KRAS Drives Metabolic Reprogramming and Autophagic Flux in Premalignant Pancreatic Cells

The authors report dynamic metabolic reprogramming in immortalized human non-cancerous pancreatic ductal epithelial cells.
[Cancer Gene Therapy]
Suzuki, T., Kishikawa, T., Sato, T., Takeda, N., Sugiura, Y., Seimiya, T., Sekiba, K., Ohno, M., Iwata, T., Ishibashi, R., Otsuka, M., & Koike, K. (2021). Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-021-00326-4 Cite
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Exosome-Delivered CD44v6/C1QBP Complex Drives Pancreatic Cancer Liver Metastasis by Promoting Fibrotic Liver Microenvironment

Researchers explored the underlying mechanisms of how pancreatic ductal adenocarcinoma-derived exosomes modulate the liver microenvironment and promote metastasis.
[Pancreas]
Xie, Z., Gao, Y., Ho, C., Li, L., Jin, C., Wang, X., Zou, C., Mao, Y., Wang, X., Li, Q., Fu, D., & Zhang, Y.-F. (2021). Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment. Gut. https://doi.org/10.1136/gutjnl-2020-323014 Cite
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Plasma Biomarkers for Prediction of Early Tumor Recurrence after Resection of Pancreatic Ductal Adenocarcinoma

Scientists identified preoperative plasma protein biomarkers with the potential to predict early recurrence after resection of PDAC.
[Scientific Reports]
Rittmann, M.-C., Hussung, S., Braun, L. M., Klar, R. F. U., Biesel, E. A., Fichtner-Feigl, S., Fritsch, R., Wittel, U. A., & Ruess, D. A. (2021). Plasma biomarkers for prediction of early tumor recurrence after resection of pancreatic ductal adenocarcinoma. Scientific Reports, 11(1), 7499. https://doi.org/10.1038/s41598-021-86779-x Cite
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Regulator of Calcineurin 1 Gene Isoform 4 in Pancreatic Ductal Adenocarcinoma Regulates the Progression of Tumor Cells

Researchers report a novel role of regulator of calcineurin 1, isoform 4 in regulating PDAC progression.
[Oncogene]
Lao, M., Zhang, X., Ma, T., Xu, J., Yang, H., Duan, Y., Ying, H., Zhang, X., Guo, C., Qiu, J., Bai, X., & Liang, T. (2021). Regulator of calcineurin 1 gene isoform 4 in pancreatic ductal adenocarcinoma regulates the progression of tumor cells. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01763-z Cite
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Locoregional Treatment of Metastatic Pancreatic Cancer Utilizing Resection, Ablation and Embolization: A Systematic Review

Investigators explore and evaluate the current evidence on locoregional treatments for metastatic PDAC.
[Cancers]
Timmer, F. E. F., Geboers, B., Nieuwenhuizen, S., Schouten, E. A. C., Dijkstra, M., de Vries, J. J. J., van den Tol, M. P., Meijerink, M. R., & Scheffer, H. J. (2021). Locoregional Treatment of Metastatic Pancreatic Cancer Utilizing Resection, Ablation and Embolization: A Systematic Review. Cancers, 13(7), 1608. https://doi.org/10.3390/cancers13071608 Cite
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AXL is a Key Factor for Cell Plasticity and Promotes Metastasis in Pancreatic Cancer

The authors used single cell RNA sequencing to reveal that AXL was expressed highly in tumor cells that had a mesenchymal-like phenotype and that AXL expression correlated with classic markers of epithelial to mesenchymal transition.
[Molecular Cancer Research]
Du, W., Phinney, N. Z., Huang, H., Wang, Z., Westcott, J., Toombs, J. E., Zhang, Y., Beg, M. S., Wilkie, T. M., Lorens, J. B., & Brekken, R. A. (2021). AXL is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0860 Cite
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BCL3 Couples Cancer Stem Cell Enrichment with Pancreatic Cancer Molecular Subtypes

Scientists demonstrated that Bcl3 impacted pancreatic carcinogenesis by restraining cancer stem cell expansion and by curtailing an aggressive and metastatic tumor burden in pancreatic ductal adenocarcinoma across species.
[Gastroenterology]
Ai, J., Wörmann, S. M., Görgülü, K., Vallespinos, M., Zagorac, S., Alcala, S., Wu, N., Kabacaoglu, D., Berninger, A., Navarro, D., Kaya-Aksoy, E., Ruess, D. A., Ciecielski, K. J., Kowalska, M., Demir, E. I., Ceyhan, G. O., Heid, I., Braren, R., Riemann, M., … Algül, H. (2021). BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2021.03.051 Cite
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Morphofunctional Analysis of Human Pancreatic Cancer Cell Lines in 2- and 3-Dimensional Cultures

Most PDAC cells showed similar pleomorphic morphologies in 2D culture. Under 3D culture, PDAC cells with high E-cadherin and low vimentin expression levels formed small round spheres encircled with flat lining cells, whereas those with high vimentin and low E-cadherin expression levels formed large grape-like spheres without lining cells and were highly proliferative.
[Scientific Reports]
Minami, F., Sasaki, N., Shichi, Y., Gomi, F., Michishita, M., Ohkusu-Tsukada, K., Toyoda, M., Takahashi, K., & Ishiwata, T. (2021). Morphofunctional analysis of human pancreatic cancer cell lines in 2- and 3-dimensional cultures. Scientific Reports, 11. https://doi.org/10.1038/s41598-021-86028-1 Cite
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Cancer-Associated Fibroblasts-Mediated ATF4 Expression Promotes Malignancy and Gemcitabine Resistance in Pancreatic Cancer via the TGF-β1/SMAD2/3 Pathway and ABCC1 Transactivation

The authors investigated the potential role and mechanisms of activating transcription factor 4 (ATF4) in cancer-associated fibroblasts-induced malignancy and gemcitabine resistance. They demonstrated that ATF4 was overexpressed in PDAC and associated with a poor prognosis.
[Cell Death & Disease]
Wei, L., Lin, Q., Lu, Y., Li, G., Huang, L., Fu, Z., Chen, R., & Zhou, Q. (2021). Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03574-2 Cite
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Morphofunctional Analysis of Human Pancreatic Cancer Cell Lines in 2- and 3-Dimensional Cultures

Scientists examined the differences in the morphological and functional characteristics of eight PDAC cell lines in 2D and 3D cultures.
[Scientific Reports]
Minami, F., Sasaki, N., Shichi, Y., Gomi, F., Michishita, M., Ohkusu-Tsukada, K., Toyoda, M., Takahashi, K., & Ishiwata, T. (2021). Morphofunctional analysis of human pancreatic cancer cell lines in 2- and 3-dimensional cultures. Scientific Reports, 11(1), 6775. https://doi.org/10.1038/s41598-021-86028-1 Cite
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Novel Candidate Factors Predicting the Effect of S-1 Adjuvant Chemotherapy of Pancreatic Cancer

Collection of an adequate number of PDAC cells is difficult due to the surrounding fibroblasts. The authors discovered novel biomarkers to predict chemosensitivity based on the collagen gel droplet-embedded drug sensitivity test results.
[Scientific Reports]
Mitachi, K., Ariake, K., Shima, H., Sato, S., Miura, T., Maeda, S., Ishida, M., Mizuma, M., Ohtsuka, H., Kamei, T., Igarashi, K., & Unno, M. (2021). Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer. Scientific Reports, 11(1), 6541. https://doi.org/10.1038/s41598-021-86099-0 Cite
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