Integrated Systems-Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1

Researchers observed both common and distinct patterns of glycosylation in pancreatic cancer across species. Common alterations included increased levels of α-2,3- and α-2,6-sialic acids, bisecting GlcNAc and poly-LacNAc.
[Molecular & Cellular Proteomics]
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Single-Cell Analysis of Patient-Derived PDAC Organoids Reveals Cell State Heterogeneity and a Conserved Developmental Hierarchy

Researchers derived pancreatic ductal adenocarcinoma organoids from 18 primary tumors and two matched liver metastases, and showed that ‘classical’ and ‘basal-like’ cells coexist in individual organoids.
[Nature Communications]
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Intravital Imaging Technology Guides FAK-Mediated Priming in Pancreatic Cancer Precision Medicine according to Merlin Status

Scientists visualized transient manipulation of focal adhesion kinase, which integrated bidirectional cell-environment signaling, using intravital fluorescence lifetime imaging microscopy of the FAK-based Förster resonance energy transfer biosensor in mouse and patient-derived pancreatic ductal adenocarcinoma models.
[Science Advances]
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Cholesterol Biosynthesis Inhibitor RO 48–8071 Inhibits Pancreatic Ductal Adenocarcinoma Cell Viability by Deactivating the JNK and ERK/MAPK Signaling Pathway

RO 48‑8071 (RO) was used to treat the pancreatic cancer cell line in vitro to examine the effects of RO on cell viability, as well as to determine its potential molecular mechanism.
[Molecular Medicine Reports]
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A 584 BP Deletion in CTRB2 Inhibits Chymotrypsin B2 Activity and Secretion and Confers Risk of Pancreatic Cancer

Scientists proposed that intracellular accumulation of a nonfunctional chymotrypsinogen B2 protein led to endoplasmic reticulum stress and pancreatic inflammation, which might explain the increased pancreatic cancer risk in carriers of CTRB2 exon 6 deletion alleles.
[American Journal of Human Genetics]
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Bioengineered 3D Models of Human Pancreatic Cancer Recapitulate In Vivo Tumor Biology

Researchers developed a comprehensive and highly tuneable ex vivo model of pancreatic ductal adenocarcinoma based on the 3D co-assembly of peptide amphiphiles with custom ECM components.
[Nature Communications]
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Proteogenomic Characterization of Pancreatic Ductal Adenocarcinoma

Towards understanding the underlying molecular alterations that drive pancreatic ductal adenocarcinoma oncogenesis, scientists conducted comprehensive proteogenomic analysis of 140 pancreatic cancers, 67 normal adjacent tissues, and 9 normal pancreatic ductal tissues.
[Cell]
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Comprehensive Analysis of the Transcriptional Expressions and Prognostic Value of S100A Family in Pancreatic Ductal Adenocarcinoma

The authors investigated the transcriptional expressions, methylation level and prognostic value of S100As in pancreatic ductal adenocarcinoma (PDAC) patients from the Oncomine, GEPIA2, Linkedomics and cBioPortal databases. Real-time PCR was used to detect the expressions of S100A2/4/6/10/14/16 in four pancreatic cancer cell lines and pancreatic cancer tissues from PDAC patients undergoing surgery.
[BMC Cancer]
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CCL2 Produced by Pancreatic Ductal Adenocarcinoma Is Essential for the Accumulation and Activation of Monocytic Myeloid-Derived Suppressor Cells

Investigators compared normal pancreatic tissues with pancreatic ductal adenocarcinoma (PDAC) tissues according to The Cancer Genome Atlas and clinical samples. Flow cytometry was used to identify M-MDSCs.
[Immunity Inflammation and Disease]
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Proteogenomic Characterization of Pancreatic Ductal Adenocarcinoma

Toward understanding the underlying molecular alterations that drive pancreatic ductal adenocarcinoma oncogenesis, scientists conducted comprehensive proteogenomic analysis of 140 pancreatic cancers, 67 normal adjacent tissues, and 9 normal pancreatic ductal tissues.
[Cell]
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Acinar Cell Clonal Expansion in Pancreas Homeostasis and Carcinogenesis

Using lineage tracing from the endogenous telomerase reverse transcriptase (Tert) locus, scientists identified a rare TERT-positive subpopulation of pancreatic acinar cells dispersed throughout the exocrine compartment.
[Nature]
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