CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma

Scientists identified CEACAM7 as a potential therapeutic target in PDAC and described the development of CEACAM7-targeted CAR T cells with efficacy against PDAC.
[Clinical Cancer Research]
Raj, D., Nikolaidi, M., Garces, I., Lorizio, D., Castro, N. M., Caiafa, S. G., Moore, K., Brown, N. F., Kocher, H. M., Duan, X., Nelson, B. H., Lemoine, N. R., & Marshall, J. F. (2021). CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-19-2163 Cite
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Ex Vivo Culture of Intact Human Patient Derived Pancreatic Tumor Tissue

To fast-track translation of therapies and to inform personalised medicine, researchers aimed to develop a whole-tissue ex vivo explant model that maintains viability, 3D multicellular architecture, and microenvironmental cues of human pancreatic tumours.
[Scientific Reports]
Kokkinos, J., Sharbeen, G., Haghighi, K. S., Ignacio, R. M. C., Kopecky, C., Gonzales-Aloy, E., Youkhana, J., Timpson, P., Pereira, B. A., Ritchie, S., Pandzic, E., Boyer, C., Davis, T. P., Butler, L. M., Goldstein, D., McCarroll, J. A., & Phillips, P. A. (2021). Ex vivo culture of intact human patient derived pancreatic tumour tissue. Scientific Reports, 11(1), 1944. https://doi.org/10.1038/s41598-021-81299-0 Cite
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Circulating Tumor Cells as an Indicator of Early and Systemic Recurrence after Surgical Resection in Pancreatic Ductal Adenocarcinoma

Researchers determined whether circulating tumor cells exist in the blood of pancreatic ductal adenocarcinoma patients and can be used as a predictor of recurrence patterns after surgical resection.
[Scientific Reports]
Park, Y., Jun, H. R., Choi, H. W., Hwang, D. W., Lee, J. H., Song, K. B., Lee, W., Kwon, J., Ha, S. H., Jun, E., & Kim, S. C. (2021). Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma. Scientific Reports, 11(1), 1644. https://doi.org/10.1038/s41598-020-80383-1 Cite
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ATDC Binds to KEAP1 to Drive NRF2-Mediated Tumorigenesis and Chemoresistance in Pancreatic Cancer

Researchers revealed that increased ataxia-telangiectasia group D-associated gene (ATDC) levels protected cancer cells from reactive oxygen species via stabilization of nuclear factor erythroid 2-related factor 2 (NRF2).
[Genes & Development]
Purohit, V., Wang, L., Yang, H., Li, J., Ney, G. M., Gumkowski, E. R., Vaidya, A. J., Wang, A., Bhardwaj, A., Zhao, E., Dolgalev, I., Zamperone, A., Abel, E. V., Magliano, M. P. D., Crawford, H. C., Diolaiti, D., Papagiannakopoulos, T. Y., Lyssiotis, C. A., & Simeone, D. M. (2021). ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer. Genes & Development. https://doi.org/10.1101/gad.344184.120 Cite
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The EGFR-HSF1 Axis Accelerates the Tumorigenesis of Pancreatic Cancer

Investigators clarified the mechanisms on early activation of heat shock factor 1 (HSF1) and its role in the pancreatic cancer tumorigenesis.
[Journal of Experimental & Clinical Cancer Research]
Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., Han, L., Li, L., Shen, X., Wu, Z., Ma, Q., & Wang, Z. (2021). The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer. Journal of Experimental & Clinical Cancer Research, 40(1), 25. https://doi.org/10.1186/s13046-020-01823-4 Cite
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CC Chemokine Receptor 2-Targeting Copper Nanoparticles for Positron Emission Tomography-Guided Delivery of Gemcitabine for Pancreatic Ductal Adenocarcinoma

Scientists engineered CCR2-targeting ultrasmall copper nanoparticles as nanovehicles not only for targeted positron emission tomography imaging by intrinsic radiolabeling with 64Cu but also for loading and delivery of the chemotherapy drug gemcitabine to pancreatic ductal carcinoma.
[ACS Nano]
CC Chemokine Receptor 2-Targeting Copper Nanoparticles for Positron Emission Tomography-Guided Delivery of Gemcitabine for Pancreatic Ductal Adenocarcinoma | ACS Nano. (n.d.). Retrieved January 8, 2021, from https://pubs.acs.org/doi/abs/10.1021/acsnano.0c08185 Cite
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Identification of a Subset of Immunosuppressive P2RX1-Negative Neutrophils in Pancreatic Cancer Liver Metastasis

RNA sequencing of murine PDAC liver metastasis-infiltrated neutrophils show that P2RX1-deficient neutrophils express increased levels of immunosuppressive molecules, including PD-L1, and have enhanced mitochondrial metabolism.
[Nature Communications]
Wang, X., Hu, L.-P., Qin, W.-T., Yang, Q., Chen, D.-Y., Li, Q., Zhou, K.-X., Huang, P.-Q., Xu, C.-J., Li, J., Yao, L.-L., Wang, Y.-H., Tian, G.-A., Yang, J.-Y., Yang, M.-W., Liu, D.-J., Sun, Y.-W., Jiang, S.-H., Zhang, X.-L., & Zhang, Z.-G. (2021). Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis. Nature Communications, 12(1), 174. https://doi.org/10.1038/s41467-020-20447-y Cite
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Visualization of Stem Cell Activity in Pancreatic Cancer Expansion by Direct Lineage Tracing with Live Imaging

Using genetic lineage tracing with a dual-recombinase system and live imaging, scientists showed that Dclk1+ tumor cells continuously provided progeny cells within pancreatic intraepithelial neoplasia, primary and metastatic PDAC and PDAC-derived spheroids in vivo and in vitro.
[eLife]
Maruno, T., Fukuda, A., Goto, N., Tsuda, M., Ikuta, K., Hiramatsu, Y., Ogawa, S., Nakanishi, Y., Yamaga, Y., Yoshioka, T., Takaori, K., Uemoto, S., Saur, D., Chiba, T., & Seno, H. (2021). Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging. ELife, 10, e55117. https://doi.org/10.7554/eLife.55117 Cite
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Deciphering the Genomic and lncRNA Landscapes of Aerobic Glycolysis Identifies Potential Therapeutic Targets in Pancreatic Cancer

Integrated analysis of transcriptional profiles revealed many differentially expressed long non-coding RNAs involved in PDAC aerobic glycolysis.
[International Journal of Biological Sciences]
Zhu, L.-L., Wu, Z., Li, R.-K., Xing, X., Jiang, Y.-S., Li, J., Wang, Y.-H., Hu, L.-P., Wang, X., Qin, W.-T., Sun, Y.-W., Zhang, Z.-G., Yang, Q., & Jiang, S.-H. (2021). Deciphering the genomic and lncRNA landscapes of aerobic glycolysis identifies potential therapeutic targets in pancreatic cancer. International Journal of Biological Sciences, 17(1), 107–118. https://doi.org/10.7150/ijbs.49243 Cite
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S100A16 Promotes Metastasis and Progression of Pancreatic Cancer through FGF19-Mediated AKT and ERK1/2 Pathways

Researchers demonstrated that S100A16 promoted PDAC cell proliferation, migration, invasion, and metastasis both in vitro and in vivo. Knockdown of S100A16 induced PDAC cell cycle arrest in the G2/M phase and apoptosis.
[Cell Biology and Toxicology]
Fang, D., Zhang, C., Xu, P., Liu, Y., Mo, X., Sun, Q., Abdelatty, A., Hu, C., Xu, H., Zhou, G., Xia, H., & Lan, L. (2021). S100A16 promotes metastasis and progression of pancreatic cancer through FGF19-mediated AKT and ERK1/2 pathways. Cell Biology and Toxicology. https://doi.org/10.1007/s10565-020-09574-w Cite
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The Expression Profile and Textural Characteristics of C595-Reactive MUC1 in Pancreatic Ductal Adenocarcinoma for Targeted Radionuclide Therapy

Scientists determined the feasibility of Mucin 1 (MUC1)-based targeted radionuclide therapy for PDAC, by evaluating the expression profile of MUC1 in different pancreatic cells and tissues using the C595 antibody.
[Cancers]
Hull, A., Li, Y., Bartholomeusz, D., Hsieh, W., Escarbe, S., Ruszkiewicz, A., & Bezak, E. (2021). The Expression Profile and Textural Characteristics of C595-Reactive MUC1 in Pancreatic Ductal Adenocarcinoma for Targeted Radionuclide Therapy. Cancers, 13(1), 61. https://doi.org/10.3390/cancers13010061 Cite
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