De Novo Expression of Gastrokines in Pancreatic Precursor Lesions Impede the Development of Pancreatic Cancer

Scientists performed the molecular and histological assessment of patient-derived PanINs, tumor tissues and pancreas from mouse models with PDAC, where they noted marked upregulation of gastrokine proteins.
[Oncogene]
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XP-524 Is a Dual-BET/EP300 Inhibitor That Represses Oncogenic KRAS and Potentiates Immune Checkpoint Inhibition in Pancreatic Cancer

Researchers demonstrated that the multispecificity BET/EP300 inhibitor XP-524 has pronounced single-agent efficacy in vitro, in vivo, and ex vivo human PDAC slice cultures, functioning in part by attenuating oncogenic KRAS signaling.
[Proceedings of the National Academy of Sciences of the United States of America]
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PD-L1 and PD-L2 Expression in Pancreatic Ductal Adenocarcinoma and Their Correlation with Immune Infiltrates and DNA Damage Response Molecules

The authors investigated the expression of two PD-1 ligands, PD-L1 and PD-L2, in pancreatic ductal adenocarcinoma, analysed their role in survival, and explored their correlation with clinicopathological features, immune infiltration, and DNA damage response molecules.
[Journal of Pathology Clinical Research]
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Matrix Remodeling-Associated Protein 8 Is a Marker of a Subset of Cancer-Associated Fibroblasts in Pancreatic Cancer

Analysis of MXRA8 expression in human pancreatic ductal adenocarcinoma samples showed that MXRA8 was differentially co-expressed with other cancer-associated fibroblasts markers.
[Pathology International]
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Analysis of the Glyco-Code in Pancreatic Ductal Adenocarcinoma Identifies Glycan-Mediated Immune Regulatory Circuits

By analysing publicly available transcriptomic data of patient samples and cell lines, researchers identified here two specific glycan profiles in pancreatic ductal adenocarcinoma that correlated with progression, clinical outcome and epithelial to mesenchymal transition status.
[Communications Biology]
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Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to Fuel Tumour Progression

Researchers demonstrated that PDAC tumors established an organised communication network between subpopulations of cancer cells using EVs called the EVNet.
[Gut]
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Progranulin Mediates Immune Evasion of Pancreatic Ductal Adenocarcinoma through Regulation of MHCI Expression

Researchers characterized the function of tumor-derived PGRN in promoting immune evasion in primary pancreatic ductal adenocarcinoma.
[Nature Communications]
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B Cell Receptor Signaling and Protein Kinase D2 Support Regulatory B Cell Function in Pancreatic Cancer

Researchers used a novel interleukin 35 reporter model to understand which signaling pathways are important for immunosuppressive properties in B cells.
[Frontiers in Immunology]
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Soluble AXL Is a Novel Blood Marker for Early Detection of Pancreatic Ductal Adenocarcinoma and Differential Diagnosis from Chronic Pancreatitis

Researchers explored the use of soluble AXL as a biomarker for pancreatic ductal adenocarcinoma. AXL was analysed by immunohistochemistry in human pancreatic tissue samples.
[Ebiomedicine]
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Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma

Cell lines were isolated from Ptf1a-Cre;LSL-KrasG12D;Rnf43flox/flox and Ptf1a-Cre; LSL-KrasG12D tumors and interrogated by cytokine array analyses, ATAC-seq and in vitro drug assays.
[Gastroenterology]
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Heterocellular OSM-OSMR Signaling Reprograms Fibroblasts to Promote Pancreatic Cancer Growth and Metastasis

Scientists described how heterocellular Oncostatin M (OSM) – Oncostatin M Receptor (OSMR) signaling reprograms fibroblasts, regulates tumor growth and metastasis.
[Nature Communications]
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