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PDAC cells

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

[Cancer Research] Investigators showed that the mitochondrial calcium uniporter promoted pancreatic ductal adenocarcinoma cell migration, invasion, metastasis, and metabolic stress resistance by activating the Keap1-Nrf2 antioxidant program.

Pancreatic Ductal Adenocarcinoma Cells Employ Integrin α6β4 to Form Hemidesmosomes and Regulate Cell Proliferation

[Matrix Biology] To identify the integrin adhesion systems that operate in PDAC, investigators analyzed a range of pancreatic ductal epithelial cell models using 2D, 3D and organoid culture systems.

Identification of Distinct Slow Mode of Reversible Adaptation of Pancreatic Ductal Adenocarcinoma to the Prolonged Acidic pH Microenvironment

[Journal of Experimental & Clinical Cancer Research] PDAC cells used a distinct and lengthy process of reversible adaptive plasticity centered on the early fast and later slow mitochondrial network dynamics and metabolic adjustment to microenvironmental acidification..

ZMAT1 Acts as a Tumor Suppressor in Pancreatic Ductal Adenocarcinoma by Inducing SIRT3/p53 Signaling Pathway

[Journal of Experimental & Clinical Cancer Research] Multiple bioinformatics analyses were used to evaluate zinc finger matrin-type 1 (ZMAT1) expression and potential role in PDAC.In vitro and in vivo studies were performed to assess the effects of ZMAT1 on PDAC cells growth.

Trefoil Factor 3 Promotes Pancreatic Carcinoma Progression via WNT Pathway Activation Mediated by Enhanced WNT Ligand Expression

[Cell Death & Disease] Researchers observed that trefoil factor 3 (TFF3) expression was elevated in PDAC, and was positively correlated with a worse overall patient survival outcome.

Pan-KRAS Inhibitors Suppress Proliferation through Feedback Regulation in Pancreatic Ductal Adenocarcinoma

[Acta Pharmacologica Sinica] Two pan-KRAS inhibitors, BI-2852 and BAY-293, were chosen as chemical probes to investigate their antitumor potency in PDAC.

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