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pancreatic cells

Cadmium Inhibits Signal Transducer and Activator of Transcription 6 Leading to Pancreatic β Cell Apoptosis

[Endocrine Journal] The toxic heavy metal cadmium has been proven to cause pancreatic dysfunction and lead to the development of DM. Researchers investigated the effects of cadmium on the pancreatic β cell line MIN6 and explored the underlying mechanisms.

Chemical Inducer of Regucalcin Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Pancreatic MIN6 β-Cells and RAW264.7 Macrophages

[Febs Open Bio] Scientists reported that derrisfolin A induced the expression of endogenous regucalcin protein in both pancreatic MIN6 β-cells and RAW264.7 macrophages.

Astragalus Polysaccharide Improve the Proliferation and Insulin Secretion of Mouse Pancreatic β Cells Induced by High Glucose and Palmitic Acid Partially through Promoting miR-136-5p...

[Bioengineered] The effect of astragalus polysaccharide on dysfunctional insulin cells was investigated to clarify whether astragalus polysaccharide could be a novel drug for type 2 diabetes mellitus treatment.

4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine Induces Immunogenic Cell Death in Colon and Pancreatic Carcinoma Models as a Single Agent

[Cancer Chemotherapy and Pharmacology] RNA sequencing experiments were conducted on PANC-1 human pancreatic cancer cells treated with Docosahexaenoyl difluorodeoxycytidine (DHA–dFdC), dFdC, or vehicle control in vitro.

SymbioCellTech Demonstrates Preclinical Efficacy of Proprietary and Novel Human Neo-Islets™ Technology in STZ-Diabetic NOD-SCID Mice

[SymbioCellTech (GlobeNewswire, Inc.)] SymbioCellTech announced the publication of a paper demonstrating the potency and efficacy of its innovative and proprietary human Neo-Islet™ in a third, clinically relevant model of human Type 1 Diabetes.

Activated but Functionally Impaired Memory Tregs Are Expanded in Slow Progressors to Type 1 Diabetes

[Diabetologia] Researchers profiled CD4+ regulatory T cells in a small but well-characterized cohort of extreme slow progressors with a median age 43, followed up for 18–32 years.

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