pancreatic cells

[Autophagy] Scientists found that adipose-specific expression of BECN1F121A was sufficient to improve systemic insulin sensitivity without negatively affecting pancreatic insulin storage.

[Nature Communications] In isolated pancreatic acinar cells, insulin induced Akt-mediated phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) which upregulated glycolysis thereby preventing POA-induced ATP depletion.

[Nature Communications] Scientists determined the pattern of long-range contacts between an enhancer in the locus and the human INS promoter 460 kb away, in the human pancreatic β-cell line, EndoC-βH1.

[Cell Death & Disease] Researchers found that dihydroartemisinin (DHA) could intensively strengthen the cytotoxicity of cisplatin and significantly reduced its effective concentrations both in vitro and in vivo.

[Scientific Reports] Metformin combined with apigenin increased ROS levels dramatically and decreased cell viability in various cancer cells including AsPC-1 cells, with each drug used singly having a minimal effect.

[Acta Diabetologica] Scientists hypothesized that erythropoietin exposure of isolated islets improved their posttransplant revascularization.