Insulin Protects Acinar Cells during Pancreatitis by Preserving Glycolytic ATP Supply to Calcium Pumps

In isolated pancreatic acinar cells, insulin induced Akt-mediated phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) which upregulated glycolysis thereby preventing POA-induced ATP depletion.