pancreatic cells

[Molecular Therapy-Nucleic Acids] Scientists screened multi-layer molecular data of 36 pancreatic cancer cell lines, including gene mutation, gene expression, miRNA expression, and protein profiles.

[Scientific Reports] Researchers revealed that angiopoietins, including angiopoietin-1 and angiopoietin-2 permitted the generation of islets from iPSCs with elevated glucose responsiveness, a hallmark of mature islets.

[Cell Reports] Researchers determined that SRC-inhibitor-mediated suppression of p130Cas phosphorylation impaired MYC transcription through a DOCK1-RAC1-β-catenin-dependent mechanism.

[Endocrine Connections] Gestating and non-gestating mice were used to evaluate the in vivo effect of oxytocin signal on β-cells during pregnancy. In vitro experiments were performed on INS-1 insulinoma cells.

[Nature Metabolism] Scientists conducted a comprehensive multi-omics analysis of pancreatic islets obtained from metabolically profiled pancreatectomized living human donors stratified along the glycemic continuum, from normoglycemia to type 2 diabetes.

[Cell Death & Disease] Scientists focused on the functional investigation of circ-0005105, a newly identified circular RNA, in pancreatic ductal adenocarcinoma progression.