High Glucose-Induced PRDX3 Acetylation Contributes to Glucotoxicity in Pancreatic β-cells: Prevention by Teneligliptin

Scientists investigated the direct effect of Teneligliptin, a newer DPP-4 inhibitor on beta-cell function and survival in response to high glucose conditions. Teneligliptin treatment enhanced SIRT1 stability and activity by USP22, a ubiquitin specific peptidase.
[zotpress userid=’6630899′ items=’45S2HVYP’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Silencing of lncRNA PVT1 Ameliorates Streptozotocin-Induced Pancreatic β Cell Injury and Enhances Insulin Secretory Capacity via Regulating miR-181a-5p

Researchers investigated the role of lncRNA plasmacytoma variant translocation 1 (PVT1) in rat insulinoma cells damaged by streptozotocin and to identify the potential mechanisms.
[zotpress userid=’6630899′ items=’DUXB8AE9′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

PAF1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions with PHF5A and DDX3

Researchers investigated mechanisms by which PAF1 maintains cancer stem cells and contributes to development of pancreatic tumors.
[Gastroenterology]
[zotpress userid=’1254621′ items=’BHJDNWSH’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Loss of HIF1A from Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis

Scientists studied the roles of hypoxia inducible factor 1 alpha (HIF1A) in development of pancreatic tumors in mice. Cancer cells were cultured from pancreatic ductal adenocarcinomas from mice and analyzed in cell migration and invasion assays and by immunoblots, real-time PCR, and liquid chromatography–mass spectrometry.
[Gastroenterology]
[zotpress userid=’6630899′ items=’MY4YFY43′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Low Glucose Enhanced Metformin’s Inhibitory Effect on Pancreatic Cancer Cells by Suppressing Glycolysis and Inducing Energy Stress via Up-Regulation of miR-210-5p

To explore mechanisms underlying the discrepancy in anti-tumor effects of metformin on pancreatic cancer cells PANC-1 under different glucose conditions, investigators cultured PANC-1 cells in 25 mM and 5 mM glucose media, then treated with or without metformin.
[Cell Cycle]
[zotpress userid=’6630899′ items=’84V3X37Z’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Regulated Expression and Function of the Gabab Receptor in Human Pancreatic Beta Cell Line and Islets

Scientists generated a new stable human beta cell line from neonatal pancreas. This cell line, named ECN90 expressed both subunits (GABBR1 and GABBR2) of the metabotropic GABAB receptor compared to human islet.
[Scientific Reports]
[zotpress userid=’6630899′ items=’XGCRX689′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Circulating Unmethylated CHTOP and INS DNA Fragments Provide Evidence of Possible Islet Cell Death in Youth with Obesity and Diabetes

The authors identified the CHTOP gene as a candidate whose CpGs show a greater frequency of unmethylation in human islets. A digital PCR strategy was used to determine the methylation pattern of CHTOP and INS CpG sites in primary human tissues.
[Clinical Epigenetics]
[zotpress userid=’6630899′ items=’YAFMXKJU’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Role of Sirtuin-1 (SIRT1) in Hypoxic Injury in Pancreatic β-Cells

Hypoxic damage significantly increased the TNF-α, IL-6 and ROS levels in INS-1 cells. However, the reduced cell viability and increased inflammatory cytokines from hypoxic damage were ameliorated by SIRT1 activation in INS-1 cells.
[Journal of Drug Targeting]
[zotpress userid=’6630899′ items=’2GPCMRJR’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3

The authors report that miR-324-5p regulated the proliferation and apoptosis of pancreatic cancer cells through regulating the expression of KLF3.
[Molecular Therapy-Oncolytics]
[zotpress userid=’6630899′ items=’R6XAEX7S’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Lentiviral Gene Therapy Vectors Encoding VIP Suppressed Diabetes-Related Inflammation and Augmented Pancreatic Beta-Cell Proliferation

The authors suggested the observed therapeutic effect of lentiviral vector carrying vasoactive intestinal peptide(VIP) gene was due to the repression of diabetes-induced inflammation, its insulinotropic properties, and VIP-induced beta-cell proliferation.
[Gene Therapy]
[zotpress userid=’6606345′ items=’68NNYJ5I’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Lactate Activation of α-Cell KATP Channels Inhibits Glucagon Secretion by Hyperpolarizing the Membrane Potential and Reducing Ca2+ Entry

Mouse and human islets were used in combination with confocal microscopy, electrophysiology, GCG immunoassays, and fluorescent thallium flux assays to assess α-cell Ca2+ handling, Vm, KATP currents, and GCG secretion.
[Molecular Metabolism]
[zotpress userid=’6606345′ items=’QJ6CFQDZ’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share
Share