pancreatic cells

[Trends in Endocrinology and Metabolism] Proper material design and biological considerations will improve the success of bioartificial pancreas for regenerative medicine in diabetes.

[Cell Reports] Scientists showed that oncogenic KRAS promoted protein kinase C-mediated NAD+ kinase (NADK) phosphorylation, leading to its hyperactivation, thus sustaining both NADP+ and NADPH levels in pancreatic ductal adenocarcinoma cells.

[Cell Chemical Biology] Investigators showed that basic nitrogen-containing residues blocked central adverse events of Dextromethorphan without reducing its anti-diabetic effects, including the protection of human pancreatic islets from cell death.

[Cell Death & Disease] Researchers found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice.

[Scientific Reports] Scientists provide a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SETD4+ cell population.

[Cancer Gene Therapy] Oncolytic viral chimera, CF33-hNIS-antiPDL1 genetically modified to express anti-human PD-L1 antibody and CF33-hNIS-Δ without the anti-PD-L1 gene, were used to investigate the immunogenic effects of oncolytic virus and virus-delivered anti-PD-L1 in pancreatic ductal adenocarcinoma in vitro.