pancreatic ductal adenocarcinoma

[Gut] Researchers demonstrated that PDAC tumors established an organised communication network between subpopulations of cancer cells using EVs called the EVNet.

[Nature Communications] Researchers characterized the function of tumor-derived PGRN in promoting immune evasion in primary pancreatic ductal adenocarcinoma.

[Frontiers in Immunology] Researchers used a novel interleukin 35 reporter model to understand which signaling pathways are important for immunosuppressive properties in B cells.

[Ebiomedicine] Researchers explored the use of soluble AXL as a biomarker for pancreatic ductal adenocarcinoma. AXL was analysed by immunohistochemistry in human pancreatic tissue samples.

[Gastroenterology] Cell lines were isolated from Ptf1a-Cre;LSL-KrasG12D;Rnf43flox/flox and Ptf1a-Cre; LSL-KrasG12D tumors and interrogated by cytokine array analyses, ATAC-seq and in vitro drug assays.

[Nature Communications] Scientists described how heterocellular Oncostatin M (OSM) - Oncostatin M Receptor (OSMR) signaling reprograms fibroblasts, regulates tumor growth and metastasis.