pancreatic ductal adenocarcinoma

[Aging] The tumor-suppressive effects of puerarin were determined by both in vitro and in vivo assays. The effects of puerarin on the proliferation, apoptosis, migration and invasion of pancreatic cancer cells, and tumor growth and metastasis in pancreatic ductal adenocarcinoma xenograft mouse model were performed.

[Oncogene] Scientists found that the 18fluoro-deoxyglucose positron emission tomography/computed tomography-based markers were positively associated with the expression of programmed cell death ligand 1, pyruvate kinase M2, both of which indicate poor prognosis in patients with pancreatic ductal adenocarcinoma.

[Pathology] The author provides a concise overview of the entire biomorphological spectrum of pancreatic ductal adenocarcinoma progression beginning with initial neoplastic transformation and ending in terminal distant metastasis.

[Clinical and Translational Oncology] Researchers investigated the effects of exosomes extracted from human umbilical cord mesenchymal stem cells carrying hsa-miRNA-128-3p on pancreatic cancer cells.

[Cell Reports] Pharmacologic inhibition of CHK1 alone caused apoptotic growth suppression of both PDAC cell lines and organoids, which correlated with loss of MYC expression.

[eLife] The authors identified that glutamine limitation in pancreatic ductal adenocarcinoma cells suppressed de novo hexosamine synthesis but resulted in increased free GlcNAc abundance.