pancreatic ductal adenocarcinoma

[International Immunopharmacology] Scientists found that C-C motif chemokine ligand 2 (CCL2) recruits monocytes to and decrease CD8+ T cell infiltration in pancreatic tumors.

[Autoimmunity] Expression of circ_0072088, microRNA (miR)-545-3p and solute carrier family 7 member 11 (SLC7A11) was detected by real-time quantitative PCR and western blotting.

[Journal of Pathology] Pancreatic ductal metaplasia (PDM) development might involve all cell lineages of the pancreas, and acinar cells with the highest plasticity are the major source of PDM.

[Scientific Reports] Scientists analyzed the transcriptome of cancer stem cells, which were converted from iPSCs with conditioned medium from pancreatic ductal adenocarcinoma cells.

[Cell Discovery] Researchers identified normal epithelial cells in the tumor lesion, which have euploid genomes, normal patterns of DNA methylation, and chromatin accessibility.

[eLife] Tumor-associated macrophages (TAMs) are abundant, and they are important mediators of disease progression and invasion. Scientists generated tumor-educated macrophages in vitro and performed detailed, multiomic characterization.