H3K27ac HiChIP in Prostate Cell Lines Identifies Risk Genes for Prostate Cancer Susceptibility

The authors assessed the utility of chromosome conformation capture coupled with immunoprecipitation (HiChIP) to identify target genes for prostate cancer genome-wide association studies risk loci.
[American Journal of Human Genetics]
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Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib in Combination with Ralaniten Analogues for the Treatment of Androgen Receptor-Positive Prostate and Breast Cancers

Androgen receptor has essential roles in the growth of prostate cancer and some breast cancers. A combination of EPI-7170 with palbociclib attenuated the in vivo growth of human castration-resistant prostate cancer xenografts that were resistant to antiandrogens.
[Molecular Cancer therapeutics]
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Sympathetic Signaling Facilitates Progression of Neuroendocrine Prostate Cancer

The authors revealed that high concentrations of the sympathetic neurotransmitter norepinephrine induced neuroendocrine differentiation-like changes in prostate cancer cells in vitro, evident by their characteristic cellular and molecular changes.
[Cell Death Discovery]
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TMPRSS4 Promotes Cancer Stem–Like Properties in Prostate Cancer Cells through Upregulation of SOX2 by SLUG and TWIST1

The authors investigated whether transmembrane serine protease 4 (TMPRSS4) confered cancer stem–like properties to prostate cancer cells and characterized the underlying mechanisms.
[Journal of Experimental & Clinical Cancer Research]
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First Subject Dosed in Biosplice Therapeutics Phase Ib Clinical Trial in Oncology

Biosplice Therapeutics, Inc. announced the dosing of the first subject in a Phase Ib, open-label, multicenter, dose-escalation, dose expansion clinical trial of cirtuvivint in subjects with advanced solid tumors.
[Biosplice Therapeutics, Inc.]
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Discovery Proteomics Defines Androgen-Regulated Glycoprotein Networks in Prostate Cancer Cells, as Well as Putative Biomarkers of Prostatic Diseases

Quantitative glycoprotein profiling identified androgen-regulated glycoprotein networks associated with supraphysiologic androgen-mediated inhibition of prostate cancer cell proliferation, and androgen-regulated glycoproteins in clinical prostate tissues.
[Scientific Reports]
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Topoisomerase II Alpha Inhibition Can Overcome Taxane-Resistant Prostate Cancer through DNA Repair Pathways

Cabazitaxel (CBZ) was approved for the treatment of docetaxel-resistant castration-resistant prostate cancer (CRPC). Researchers explored the optimal treatment for CRPC in the post-cabazitaxel setting using PC3 (CBZ-sensitive) and PC3CR cells (CBZ-resistant).
[Scientific Reports]
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G3BP1 Inhibits Cul3SPOP to Amplify AR Signaling and Promote Prostate Cancer

Scientists identified G3BP1 as an interactor of SPOP and functions as a competitive inhibitor of Cul3SPOP, suggesting a distinctive mode of Cul3SPOP inactivation in prostate cancer.
[Nature Communications]
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Transcription Factor p53-Mediated Activation of miR-519d-3p and Downregulation of E2F1 Attenuates Prostate Cancer Growth and Metastasis

Investigators uncovered that the transcription factor p53 could upregulate miR-519d-3p expression to directly suppress the expression of E2F transcription factor 1 (E2F1), thus inhibiting prostate cancer growth and metastasis.
[Cancer Gene Therapy]
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Demethyltransferase FTO Alpha-Ketoglutarate Dependent Dioxygenase (FTO) Regulates the Proliferation, Migration, Invasion and Tumor Growth of Prostate Cancer by Modulating the Expression of Melanocortin 4 Receptor (MC4R)

The authors investigated the function and mechanism of demethyltransferase fat mass and obesity-associated protein (FTO) in prostate cancer (PCa). FTO regulated the proliferation, migration and invasion of PCa via regulating the expression level of MC4R.
[Bioengineered]
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The Metastasis Suppressor NDRG1 Directly Regulates Androgen Receptor Signaling in Prostate Cancer

Scientists examined for the first time the effect of N-myc-downregulated gene 1 (NDRG1) on androgen receptor expression, activation, and downstream signaling in LNCaP, 22Rv1 and C4-2B prostate cancer cell types.
[Journal of Biological Chemistry]
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