prostate cancer

[Prostate] Through co-targeting the androgen receptor (AR) signaling, Diptoindonesin G robustly improved the efficacy of HSP90 inhibitors and enzalutamide in both human prostate cancer cells and in vivo xenograft mouse model.

[Communications Biology] Researchers reported that autophagy affected differently the response of prostate cancer cell lines to olaparib depending on its activation status.

[Molecular Cancer] miR-346 could be particularly effective as a therapeutic in the context of decreased NORAD observed in advanced prostate cancer, and in transcriptionally-hyperactive cancer cells.

[Oncology Reports] The authors investigated the use of designed ankyrin repeat protein Ec1 for targeted delivery of Pseudomonas exotoxin A variant (LoPE) with low immunogenicity and low non‑specific toxicity to epithelial cell adhesion molecule‑expressing prostate cancer cells.

[Cell Death & Disease] Scientists detected that the loss of the androgen-responsive transcription factor, zinc finger, and BTB domain containing 10 (ZBTB10), could activate pyruvate kinase L/R to enhance a neuroendocrine differentiation response that was associated with glucose uptake by prostate cancer cells.

[Journal of Experimental & Clinical Cancer Research] The authors provide a mechanistic discussion of autophagy in prostate cancer.