Epithelial Cell Adhesion Molecule-Targeting Designed Ankyrin Repeat Protein-Toxin Fusion Ec1-LoPE Exhibits Potent Cytotoxic Action in Prostate Cancer Cells

The authors investigated the use of designed ankyrin repeat protein Ec1 for targeted delivery of Pseudomonas exotoxin A variant (LoPE) with low immunogenicity and low non‑specific toxicity to epithelial cell adhesion molecule‑expressing prostate cancer cells.