prostate cancer

[Wales 247] Researchers from Cardiff University have received a grant worth over £230,000 from leading men’s health charity Prostate Cancer UK. The funding will help them develop a deeper understanding of how prostate cancer affects the immune system, so it’s clearer which men could benefit from powerful new immunotherapy treatments.

[Oncology Reports] The authors highlight the latest research progress made in the biological functions and regulation of PIWI‑interacting RNA in mammals, their involvement in various cancer forms and their potential clinical applications.

[Journal of Antibiotics] From the natural product screening, the novel compound arabilin was isolated from Streptomyces sp. MK756-CF1. Unlike STK765173, arabilin could overcome resistance to enzalutamide.

[Cell Death & Disease] The authors performed a kinome-scale CRISPR/Cas9 screen and identified cyclin-dependent kinase 12 (CDK12) as being conservatively required for PCa cell survival.

[Scientific Reports] Researchers characterized the biodistribution and pharmacokinetics of [68Ga]PSMA-11 in prostate-specific membrane antigen (PSMA)-positive and negative tumor-bearing mice and subsequently estimated its internal radiation dosimetry via voxel-level dosimetry using a dedicated Monte Carlo simulation to evaluate the absorbed dose in the tumor directly.

[Cancer Research] Scientists interrogated the regulation of RE1-silencing transcription factor, a transcriptional repressor of neuronal genes, and elucidated molecular programs driving amphicrine prostate cancer and neuroendocrine prostate cancer biology.