Biodistribution and Internal Radiation Dosimetry of a Companion Diagnostic Radiopharmaceutical, [⁶⁸Ga]PSMA-11, in Subcutaneous Prostate Cancer Xenograft Model Mice

Researchers characterized the biodistribution and pharmacokinetics of [68Ga]PSMA-11 in prostate-specific membrane antigen (PSMA)-positive and negative tumor-bearing mice and subsequently estimated its internal radiation dosimetry via voxel-level dosimetry using a dedicated Monte Carlo simulation to evaluate the absorbed dose in the tumor directly.