Pyruvate-Lactate Exchange and Glucose Uptake in Human Prostate Cancer Cell Models. A Study in Xenografts and Suspensions by Hyperpolarized [113C]pyruvate MRS and [18F]FDG-PET

Scientists compared murine xenografts of human prostate cancer LNCaP cells with those of more aggressive PC3 cells.
[Nmr in Biomedicine]
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MEIS1 Down-Regulation by MYC Mediates Prostate Cancer Development through Elevated HOXB13 Expression and AR Activity

Knockdown of MYC expression in prostate cancer cells increased the expression of MEIS1 and increased the occupancy of MYC at the MEIS1 locus.
[Oncogene]
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Differential Impact of Paired Patient-Derived BPH and Normal Adjacent Stromal Cells on Benign Prostatic Epithelial Cell Growth in 3D Culture

Coculture of the primary stromal cells with benign human prostate epithelial cell lines BHPrE1 or benign prostatic hyperplasia (BPH)-1 was performed in three‐dimensional Matrigel to determine the impact of primary stromal cells derived from BPH on epithelial proliferation.
[Prostate]
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CXCL12γ Induces Human Prostate and Mammary Gland Development

Overexpression of CXCL12γ promoted the reprogramming of cells with a differentiated luminal phenotype to a nonluminal phenotype in both prostate and mammary epithelial cells.
[Prostate]
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Combination of Curcumin and Metformin Inhibits Cell Growth and Induces Apoptosis without Affecting the Cell Cycle in LNCaP Prostate Cancer Cell Line

Scientists investigated the combined effect of curcumin and metformin on the LNCaP prostate cancer cell line. LNCaP cells were treated with curcumin, metformin, and their combination at different concentrations.
[Nutrition and Cancer-An International Journal]
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Neuroendocrine Differentiation in Usual-Type Prostatic Adenocarcinoma: Molecular Characterization and Clinical Significance

Benign neuroendocrine cells expressed significantly lower quantified androgen receptor levels compared with paired benign luminal cells.
[Prostate]
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Skp2 Dictates Cell Cycle-Dependent Metabolic Oscillation between Glycolysis and TCA Cycle

Scientists found that elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.
[Cell Research]
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NCL Inhibition Exerts Antineoplastic Effects against Prostate Cancer Cells by Modulating Oncogenic MicroRNAs

Investigators demonstrated that nucleolin (NCL) was expressed on the surface of all three tested cell lines and that NCL inhibition resulted in reduced proliferation and migration.
[Cancers]
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Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer

The authors summarize the current knowledge of therapeutic induction and intracellular pathways of androgen receptor-mediated cellular senescence.
[Cancers]
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Thioredoxin Interacting Protein (TXNIP) Acts as a Tumor Suppressor in Human Prostate Cancer

Researchers reported that the expression of thioredoxin interacting protein (TXNIP) was significantly decreased in prostate cancer and associated with clinicopathological features. Overexpression of TXNIP could significantly inhibit PC‐3 cells proliferation, migration, invasion and glucose uptake.
[Cell Biology International]
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Targeting CPT1B as a Potential Therapeutic Strategy in Castration-Resistant and Enzalutamide-Resistant Prostate Cancer

The CCK-8 experiment demonstrated that CPT1B overexpression in C4-2 cells did not significantly increase the ability of enzalutamide resistance. However, overexpression of CPT1B in C4-2R cells significantly increased the enzalutamide resistance.
[Prostate]
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