prostate cells

[Proteomics Clinical Applications] To model the problem of radiation resistance in prostate cancer, cell lines mimicking a clinical course of conventionally fractionated or hypofractionated radiotherapy have been generated.

[Science Signaling] In addition to hepatocytes, several hepsin-producing prostate cancer cell lines showed reduced STING-mediated type I interferon induction and responses.

[Science Signaling] Researchers reported that the transmembrane protease hepsin, which was predominantly present in hepatocytes, inhibited the induction of type I IFN during viral infections.

[Cell Biochemistry and Function] Scientists employed a co-culture system to evaluate the anti-epithelial-mesenchymal transition effects of human amniotic mesenchymal stromal cells on LNCaP PCa cells.

[Biomolecules & Therapeutics] The authors reported that mammalian target of rapamycin (mTOR) is a key regulator of hyaluronan-mediated motility receptor (HMMR) expression, for which its kinase activity is required. Pharmacological inhibitors of mTOR markedly suppressed the mRNA level as well as the protein level of HMMR in LNCaP and PC-3 cells.

[Journal of Medicinal Chemistry] NUC-1031 preferentially targeted leukemic stem cells in primary AML samples and cancer stem cells in the prostate cancer cell line, LNCaP..