pulmonary cells

[Journal of Cellular Physiology] LINC00662 can reduce the promoter methylation level of s-adenosylmethionine-dependent hepatocellular carcinoma-promoting genes by regulating the MAT1A/SAM and AHCY/SAH axes, thereby promoting the activation of oncogenes. Scientists summarize the molecular regulation mechanism of LINC00662.

[Science Translational Medicine] Lung autopsy samples from 18 patients with fatal COVID-19, with symptom onset-to-death times ranging from 3 to 47 days, and antemortem plasma samples from 6 of these cases were evaluated using deep sequencing of SARS-CoV-2 RNA, multiplex plasma protein measurements, and pulmonary gene expression and imaging analyses.

[Pediatric Pulmonology] Human bronchial epithelial cells BEAS-2B were stimulated with transforming growth factor-β1 at a concentration of 10 ng/mL, and CCCTC-binding factor (CTCF) overexpression plasmid and CTCF small interfering RNA were transfected into the cells.

[Environmental and Molecular Mutagenesis] While in vitro studies were often based on submerged exposures, this study aimed to expose A549 alveolar epithelial cells at the air-liquid interface (ALI) to unravel the genotoxic and oxidative stress-inducing potential of dibutyl phthalate (DBP) with concentrations relevant at occupational settings.

[Cell Death Discovery] The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.

[Evidence-Based Complementary and Alternative Medicine] As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.