Researchers generated a humanized-mouse melanoma model by injecting fetal liver-derived CD34+ cells and implanting autologous thymus in immune-deficient NOD-scid IL2Rγnull mice.
[Nature Communications]
Somasundaram, R., Connelly, T., Choi, R., Choi, H., Samarkina, A., Li, L., Gregorio, E., Chen, Y., Thakur, R., Abdel-Mohsen, M., Beqiri, M., Kiernan, M., Perego, M., Wang, F., Xiao, M., Brafford, P., Yang, X., Xu, X., Secreto, A., … Herlyn, M. (2021). Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy. Nature Communications, 12(1), 346. https://doi.org/10.1038/s41467-020-20600-7 Cite
0