Loss of NFE2L3 Protects against Inflammation-Induced Colorectal Cancer through Modulation of the Tumor Microenvironment

Researchers investigated the role of the NFE2L3 transcription factor in inflammation-induced colorectal cancer.
[Oncogene]
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Physiological Levels of 25-Hydroxyvitamin D3 Induce a Suppressive CD4+ T Cell Phenotype Not Reflected in the Epigenetic Landscape

The authors analyzed the influence of its precursor 25-hydroxyvitamin D3 on the differentiation of human CD4+ T cells applying physiological concentrations in vitro.
[Scandinavian Journal of Immunology]
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Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

Researchers interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-derived glioblastoma (GBM) stem cells (GSCs), differentiated GBM cells, and neural stem cells to identify master regulators of GSC stemness.
[Cancer Discovery]
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K63 Ubiquitination in Immune Signaling

The authors detail the novel cellular sensors that are dependent on K63 ubiquitination for their function in the immune signaling network.
[Trends in Immunology]
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Autologous Humanized Mouse Models of iPSC-Derived Tumors Enable Characterization and Modulation of Cancer-Immune Cell Interactions

Scientists showed that fibroblastic, hepatic, or neural tumors were all efficiently infiltrated and partially or totally rejected by autologous immune cells in humanized mice.
[Cell Reports Methods]
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FoxP3 Associates with Enhancer-Promoter Loops to Regulate Treg-Specific Gene Expression

Investigators applied chromatin conformation capture with immunoprecipitation in Treg and closely related conventional CD4+ T cells.
[Science Immunology]
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Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8+ T Cells and Enhances Survival in Mouse Glioma Models

Researchers assessed regulatory T cells and cytotoxic T lymphocytes in the tumor microenvironment, cervical lymph nodes, spleen, and thymus; and hematopoietic stem and progenitor cells in the bone marrow.
[Clinical Cancer Research]
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Androgen Receptor Signaling Promotes Treg Suppressive Function during Allergic Airway Inflammation

Using androgen receptor (AR) deficient and Foxp3 fate-mapping mice, researchers determined that AR signaling increased Treg suppression during Alternaria extract challenge by stabilizing Foxp3+ Tregs and limiting the number of ST2+ ex-Tregs and IL-13+ Th2 and ex-Tregs.
[Journal of Clinical Investigation]
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Cytosporone B (Csn-B), an NR4A1 Agonist, Attenuates Acute Cardiac Allograft Rejection by Inducing Differential Apoptosis of CD4+ T Cells

Researchers revealed that nuclear receptor subfamily 4 Group A member 1 was upregulated during cardiac allograft rejection and that the increased Nr4A1 was primarily localized in intragraft-infiltrating CD4+ T cells.
[International Immunopharmacology]
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EBV+ Tumors Exploit Tumor Cell-Intrinsic and -Extrinsic Mechanisms to Produce Regulatory T Cell-Recruiting Chemokines CCL17 and CCL22

Both in vitro and in vivo Treg migration was effectively blocked by a novel, small molecule antagonist of CCR4, CCR4-351.
[PLoS Pathogens]
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Long Noncoding RNA HOTAIRM1 Promotes Immunosuppression in Sepsis by Inducing T Cell Exhaustion

Using a mouse model of sepsis, scientists found that the long noncoding RNA HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) was highly expressed in mice during the late phase of sepsis.
[Journal of Immunology]
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