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regulatory T cells

Immune Regulation News

Ubiquitin-Like Protein 3 (UBL3) Is Required for MARCH Ubiquitination of Major Histocompatibility Complex Class II and CD86

[Nature Communications] Researchers showed, using a genome-wide CRISPR knockout screen, that UBL3 was a necessary component of ubiquitination-mediated trafficking of major histocompatibility complex class II and CD86 in mice and in humans.
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Immune Regulation News

PD-1 Cooperates with AIRE-Mediated Tolerance to Prevent Lethal Autoimmune Disease

[Proceedings of the National Academy of Sciences of the United States of America] Using a range of mouse genetic models, researchers uncovered a critical tolerogenic axis between the autoimmune regulator, AIRE, and the immune checkpoint molecule, PD-1.
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Immune Regulation News

CCR2/CCR5 Inhibitor Permits the Radiation-Induced Effector T Cell Infiltration in Pancreatic Adenocarcinoma

[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.
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Immune Regulation News

Ubiquitin-Like Protein 3 (UBL3) Is Required for MARCH Ubiquitination of Major Histocompatibility Complex Class II and CD86

[Nature Communications] Researchers showed, using a genome-wide CRISPR knockout screen, that UBL3 was a necessary component of ubiquitination-mediated trafficking of major histocompatibility complex class II and CD86 in mice and in humans.
View Details >
Immune Regulation News

PD-1 Cooperates with AIRE-Mediated Tolerance to Prevent Lethal Autoimmune Disease

[Proceedings of the National Academy of Sciences of the United States of America] Using a range of mouse genetic models, researchers uncovered a critical tolerogenic axis between the autoimmune regulator, AIRE, and the immune checkpoint molecule, PD-1.
View Details >
Immune Regulation News

CCR2/CCR5 Inhibitor Permits the Radiation-Induced Effector T Cell Infiltration in Pancreatic Adenocarcinoma

[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.
View Details >
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