The authors showed for the first time that the immune response is altered as a result of syngeneic neonatal cardiomyocyte transplantation after myocardial infarction leading to improved cardiac pump function as observed by magnetic resonance imaging in C57BL/6J mice.
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Vasudevan, P., Wolfien, M., Lemcke, H., Lang, C. I., Skorska, A., Gaebel, R., Koczan, D., Lindner, T., Engelmann, R., Vollmar, B., Krause, B. J., Wolkenhauer, O., Lang, H., Steinhoff, G., & David, R. (2020). Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart. Cells, 9(8), 1825. https://doi.org/10.3390/cells9081825 Cite
Purified B cells from such patients generated more IL-35 after stimulation by antigens of Mycobacterium tuberculosis and secreted more IL-10.
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Chen, C., Xu, H., Peng, Y., Luo, H., Huang, G.-X., Wu, X.-J., Dai, Y.-C., Luo, H.-L., Zhang, J.-A., Zheng, B.-Y., Zhang, X.-N., Chen, Z. W., & Xu, J.-F. (2020). Elevation in the counts of IL-35-producing B cells infiltrating into lung tissue in mycobacterial infection is associated with the downregulation of Th1/Th17 and upregulation of Foxp3 + Treg. Scientific Reports, 10(1), 13212. https://doi.org/10.1038/s41598-020-69984-y Cite
Continue reading “Elevation in the Counts of IL-35-Producing B Cells Infiltrating into Lung Tissue in Mycobacterial Infection Is Associated with the Downregulation of Th1/Th17 and Upregulation of Foxp3+Treg”
Scientists investigated the in vivo regulation of IFN-γ production by CD8+ T cells, DN T cells and NK cells in response to acute Toxoplasma gondii infection.
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Kupz, A., Pai, S., Giacomin, P. R., Whan, J. A., Walker, R. A., Hammoudi, P.-M., Smith, N. C., & Miller, C. M. (2020). Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells. Scientific Reports, 10(1), 13115. https://doi.org/10.1038/s41598-020-70102-1 Cite
Adipose tissue mesenchymal stem cells were able to delay the onset of collagen-induced arthritis, suppress the ongoing clinical and histopathological signs, decrease serum levels of TNF-α and anti-collagen type II, and downregulate the autoreactive T cells as etanercept.
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El-Gendy, H., Hawass, S. E.-D., Awad, M., Mohsen, M. A., Amin, M., Abdalla, H. A., Fouad, S., & Lotfy, A. (2020). Comparative study between human mesenchymal stem cells and etanercept as immunomodulatory agents in rat model of rheumatoid arthritis. Immunologic Research. https://doi.org/10.1007/s12026-020-09132-w Cite
Investigators analyzed the apoptosis-inducing effect of high dose in vitro dexamethasone treatment in mouse thymic- and splenic Tregs and CD4+ T cells.
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Investigators used two-photon microscopy to elucidate the spatial organization, motility characteristics, and interactions of endogenous Treg and Th17 cells together with antigen-presenting cells within the spinal cord leptomeninges in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.
[Proceedings of the National Academy of Sciences of the United States of America]
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Othy, S., Jairaman, A., Dynes, J. L., Dong, T. X., Tune, C., Yeromin, A. V., Zavala, A., Akunwafo, C., Chen, F., Parker, I., & Cahalan, M. D. (2020). Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2006895117 Cite
The authors used a post-test control group design. MSCs were obtained from human umbilical cord blood and characterized according to their surface antigen expression and multilineage differentiation capacities.
[Journal of the Formosan Medical Association]
Renal cell carcinoma is considered to be an immunogenic tumor but is known to mediate immune dysfunction in large part by eliciting the infiltration of immune-inhibitory cells, such as regulatory T cells and myeloid-derived suppressor cells, into the tumor microenvironment.
[Nature Reviews Nephrology]
Exosomes were isolated from control and IFN-γ-primed mesenchymal stem cells and were verified by transmission electron microscope and immunofluorescence staining.
[Cell Death & Disease]
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Researchers report that IL-7Rα downregulation was necessary to maximize IL-2R signaling. While IL-7Rα overexpression promoted IL-7 signaling, unexpectedly, IL-2 signaling was suppressed in the same cells.
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Waickman, A. T., Keller, H. R., Kim, T.-H., Luckey, M. A., Tai, X., Hong, C., Molina-Paris, C., Walsh, S. T. R., & Park, J.-H. (2020). The cytokine receptor IL-7Rα impairs IL-2 receptor signaling and constrains the in vitro differentiation of Foxp3+ Treg cells. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101421 Cite
Researchers present a simple approach for islet preconditioning that uses the antibiotic mitomycin C, which has antitumor activity, to reduce islet immunogenicity and prevent proinflammatory events in an intraportal islet transplantation model.
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The authors aimed to identify the lymphocytic response to a xenogeneic human umbilical cord-derived mesenchymal stem cell-based cell therapy.
[Veterinary Immunology and Immunopathology]
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