sarcoma

[T–Cure Bioscience, Inc.] T–Cure Bioscience, Inc. announced that the US FDA has approved the Investigational New Drug application to initiate a Phase I clinical study evaluating a T cell receptor (TCR)–based product candidate for the treatment of tumors expressing Kita–Kyushu lung cancer antigen 1 (KK-LC-1), such as gastric, cervical, lung, breast cancers and other KK–LC–1 positive epithelial cancers.

[Memorial Sloan Kettering Cancer Center] Memorial Sloan Kettering Cancer Center has received a major grant from the US National Institutes of Health to conduct research related to leukemia.

[Journal of Nanobiotechnology] Polylactide polymeric nanoparticles were generated by nanoprecipitation. Liposomes were prepared by ethanol injection and evaporation solvent method.

[Scientific Reports] Scientists demonstrated that protein disulphide isomerase (PDI) was protective against mutant Fused in Sarcoma (FUS). In neuronal cell line and primary cultures, PDI restored defects in nuclear import, prevented the formation of mutant FUS inclusions, inhibited Golgi fragmentation, ER stress, ER-Golgi transport defects, and apoptosis.

[Scientific Reports] Scientists evaluated the clinical outcomes of the frozen autograft reconstruction focusing on skeletally mature adolescents and young adults that was 15 to 39 years of age.

[Cell Death & Disease] Using a proteomic approach, investigators analyzed the protein content of plasma extracellular vesicles and identified critical activated pathways in human umbilical vein endothelial cells and human progenitor hematopoietic cells.