SARS-CoV-2

[Science Immunology] The authors discuss the emerging understanding of how SARS-CoV-2 and host-derived molecules activate specific pattern recognition receptors to elicit protective interferon responses and pathological cytokine responses.

[Nature Microbiology] Researchers compared SARS-CoV-2-specific antibody and T cell responses between older adults and a younger control group after receiving two doses of BNT162b2.

[NPJ Vaccines] IgG from plasma of Ad26.COV2.S vaccinated individuals was purified and transferred into naïve golden Syrian hamster recipients, followed by intra-nasal challenge of the hamsters with SARS-CoV-2.

[Nature Communications] Investigators described the isolation of a nanobody that interacted simultaneously with two RBDs from different spike trimers of SARS-CoV-2, rapidly inducing the formation of spike trimer–dimers leading to the loss of their ability to attach to the host cell receptor, ACE2.

[Journal of Cachexia Sarcopenia and Muscle] Researchers discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post-viral fatigue syndrome.

[Nature Metabolism] The authors connected the circulating protein GP73 with enhanced hepatic gluconeogenesis during SARS-CoV-2 infection.