SARS-CoV-2

[Cell Discovery] Researchers demonstrated that intranasal inoculation with SARS-CoV-2 induced robust viral replication in the olfactory epithelium, not the olfactory bulb, resulting in transient olfactory dysfunction in humanized ACE2 mice.

[Nature Communications] The authors conducted a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and tested specific antibody responses

[Cell Death & Differentiation] When comparing nasopharyngeal swabs from cancer and noncancer patients for RT-qPCR cycle thresholds measuring acute respiratory SARS-CoV-2 in 1063 patients, researchers found that malignant disease favored the magnitude and duration of viral RNA shedding concomitant with prolonged serum elevations of type 1 IFN that anticorrelated with anti-RBD IgG antibodies.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists generated a series of deuterated variants of a 3CLpro inhibitor, GC376, and evaluated the antiviral effect against SARS-CoV-2.

[Nature Reviews Immunology] dentifying the mechanisms of protection as well as correlates of protection is crucially important to inform further vaccine development and guide the use of licensed COVID-19 vaccines worldwide.

[Cell] Investigators applied structure-based network analysis and assessments of HLA class I-peptide stability to define mutationally constrained CD8+ T cell epitopes across the SARS-CoV-2 proteome.