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schizophrenia

Involvement of Vascular Endothelial Growth Factor in Schizophrenia

[Neuroscience Letters] Scientists analyze the literature data concerning the role of vascular endothelial growth factor in modulating the angiogenic response in Schizophrenia.

Translational Evidence for Lithium-Induced Brain Plasticity and Neuroprotection in the Treatment of Neuropsychiatric Disorders

[Translational Psychiatry] The authors focus on neural adaptations that may underlie psychostimulant-induced psychotic development and to dissect, through the sensitization process, which features are shared in bipolar disorder and other psychiatric disorders, including schizophrenia.

Neuronal and Glial 3D Chromatin Architecture Informs the Cellular Etiology of Brain Disorders

[Nature Communications] Scientists integrated genome-wide chromosome conformation data from purified neurons and glia with transcriptomic and enhancer profiles, to characterize the gene regulatory landscape of two major cell classes in the human brain.

Dysregulation of Brain and Choroid Plexus Cell Types in Severe COVID-19

[Nature] Scientists discovered COVID-19 disease-associated microglia and astrocyte subpopulations that share features with pathological cell states reported in human neurodegenerative disease4–6.

Atypical Antipsychotic Olanzapine Inhibits Voltage-Dependent K+ Channels in Coronary Arterial Smooth Muscle Cells

[Pharmacological Reports] Electrophysiological recordings were performed in freshly isolated coronary arterial smooth muscle cells to investigate the inhibitory effect of olanzapine on voltage-dependent K+ channels.

Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons

[Proceedings of the National Academy of Sciences of the United States of America] Scientists described a multicenter effort to test the generality of this pivotal observation, using independent analyses at two laboratories of patient-derived and newly engineered human neurons with heterozygous NRXN1 deletions.

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