serotonin-dopamine

[Nature Communications] Scientists evaluated the safety and efficacy of dopaminergic progenitors (DAPs) derived from a clinical-grade human iPSC line. They confirmed the characteristics of DAPs by in vitro analyses.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers established a humanized transplantation model of Parkinson’s disease that better recapitulates the main disease features, obtained by coinjection of preformed human α-synuclein (α-syn) fibrils and adeno-associated virus expressing human wild-type α-syn unilaterally into the rat substantia nigra.