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skeletal muscle cells

CRISPR Gene Editing in Pluripotent Stem Cells Reveals the Function of MBNL Proteins during Human In Vitro Myogenesis

[Human Molecular Genetics] Researchers generated human-iPSCs depleted in MBNL proteins and evaluated the consequences of their losses on the generation of skeletal muscle cells.

Update on the Effects of Microgravity on the Musculoskeletal System

[NPJ Microgravity] Scientists review the catabolic effects microgravity exposure has on both bone and skeletal muscle cells, as well as their respective progenitor stem cells.

The Golgi Apparatus Is the Main Microtubule-Organizing Center in Differentiating Skeletal Muscle Cells

[Histochemistry and Cell Biology] Researchers investigated the positional relationship between the microtubule nucleating sites and the Golgi apparatus in C2C12 myotubes and in primary cultured mouse skeletal myotubes.

Scholar Rock Receives Fast Track Designation from the US FDA for Apitegromab for the Treatment of Patients with Spinal Muscular Atrophy

[Scholar Rock (Business Wire, Inc.)] Scholar Rock, a clinical-stage biopharmaceutical company, announced that the US FDA has granted Fast Track designation for apitegromab, a selective inhibitor of myostatin activation, for the treatment of patients with Spinal Muscular Atrophy.

Skeletal Muscle Fibers Count on Nuclear Numbers for Growth

[Seminars in Cell & Developmental Biology] The authors review recent advances that elucidate the relationship between myonuclear numbers and establishment of myofiber size, and discuss how this new information refines our understanding of the concept of myonuclear domains, the cytoplasmic volumes that each resident myonucleus can support.

Differential Regulation of Autophagy by STAU1 in Alveolar Rhabdomyosarcoma and Non‐Transformed Skeletal Muscle Cells

[Cellular Oncology] The authors assessed the impact of Staufen1 (STAU1) expression modulation in ARMS cell lines, non-transformed skeletal muscle cells and STAU1-transgenic mice using complementary techniques.

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