smooth muscle cells

[Kaohsiung Journal of Medical Sciences] Scientists deciphered the role of the lncRNA antisense noncoding RNA in the INK4 locus in airway smooth muscle cell proliferation, migration and extracellular matrix deposition.

[Journal of Cardiovascular Pharmacology] Researchers investigated the effect of circLDLR on the proliferation and apoptosis of vascular smooth muscle cells in coronary artery disease and its regulatory mechanism.

[Scientific Reports] Researchers elucidated the overall smoking-induced miRNA changes and those specific to chronic obstructive pulmonary disease (COPD).They investigated the downstream effects on regulatory gene expression and the correlation to cellular composition.

[Scientific Reports] Investigators investigated the role of lipid phosphate phosphatase 3 and lysophospholipid signaling in a well-defined model of pathologic aortic injury.

[Cell Death & Disease] Researchers demonstrated that a positive correlation of protein arginine methyltransferase 5 (PRMT5) expression and trimethylamine N-oxide (TMAO)-induced vascular inflammation, with upregulated vascular cell adhesion molecule-1 expression in primary rat and human vascular smooth muscle cells in vitro.

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Early vascular aging (EVA) is distinct from chronological ageing, and research is ongoing to identify a definitive molecular signature of EVA. This will facilitate the discovery of new clinical tests for early detection of EVA and identify therapeutic targets to halt (or prevent) EVA in smooth muscle cells, thus reducing macrovascular morbidity and mortality.