PRMT5 Critically Mediates TMAO-Induced Inflammatory Response in Vascular Smooth Muscle Cells

Researchers demonstrated that a positive correlation of protein arginine methyltransferase 5 (PRMT5) expression and trimethylamine N-oxide (TMAO)-induced vascular inflammation, with upregulated vascular cell adhesion molecule-1 expression in primary rat and human vascular smooth muscle cells in vitro.