The microRNA miR-134-5p Induces Calcium Deposition by Inhibiting Histone Deacetylase 5 in Vascular Smooth Muscle Cell

Researchers report that the microRNA miR‐134‐5p potentiated inorganic phosphate‐induced calcium deposition in vascular smooth muscle cells by inhibiting histone deacetylase 5.
[Journal of Cellular and Molecular Medicine]
The microRNA miR‐134‐5p induces calcium deposition by inhibiting histone deacetylase 5 in vascular smooth muscle cells - Choe - - Journal of Cellular and Molecular Medicine - Wiley Online Library. (n.d.). Retrieved August 13, 2020, from https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.15670 Cite
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Aligned Nanofiber Scaffolds Improve Functionality of Cardiomyocytes Differentiated from Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells

Scientists showed that the 3D culture with aligned nanofiber scaffolds, mimicing the architecture of the extracellular matrix of the heart, improved the differentiation of iPSC-cardiac progenitor cells to functional cardiomyocytes induced by Wnt inhibition, as shown with increased number of cardiac Troponin T-positive cells and synchronized intracellular Ca2+ oscillation.
[Scientific Reports]
Ding, M., Andersson, H., Martinsson, S., Sabirsh, A., Jonebring, A., Wang, Q.-D., Plowright, A. T., & Drowley, L. (2020). Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells. Scientific Reports, 10(1), 13575. https://doi.org/10.1038/s41598-020-70547-4 Cite
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Intercellular Communication Controls Agonist-Induced Calcium Oscillations Independently of Gap Junctions in Smooth Muscle Cells

Investigators report the existence of a communication system among human smooth muscle cells that used mechanical forces to frequency modulate long-range calcium waves.
[Science Advances]
Stasiak, S. E., Jamieson, R. R., Bouffard, J., Cram, E. J., & Parameswaran, H. (2020). Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells. Science Advances, 6(32), eaba1149. https://doi.org/10.1126/sciadv.aba1149 Cite
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An Immunohistochemical Prostate Cell Identification Key Indicates that Aging Shifts Procollagen 1A1 Production from Myofibroblasts to Fibroblasts in Dogs Prone to Prostate-Related Urinary Dysfunction

Scientists characterized the regional distribution of prostatic cell types in the young intact dog to enable comparisons with human and mice and they examined how the cellular source of procollagen 1A1 changes with age in intact male dogs.
[PLoS One]
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miR-20a-5p Promotes Pulmonary Artery Smooth Muscle Cell Proliferation and Migration by Targeting ABCA1

Reverse transcription polymerase chain reaction was employed to detect miR‐20a‐5p and ATP‐binding cassette subfamily A member 1 messenger RNA expression.
[Journal of Biochemical and Molecular Toxicology]
Zhou, Y., Fang, X., Zhang, Y., Feng, Y., & Wang, S. (n.d.). miR-20a-5p promotes pulmonary artery smooth muscle cell proliferation and migration by targeting ABCA1. Journal of Biochemical and Molecular Toxicology, n/a(n/a), e22589. https://doi.org/10.1002/jbt.22589 Cite
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Pyruvate Kinase M2 Activation Protects against the Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

Investigators demonstrated that pyruvate kinase M2 stimulated inflammatory and apoptosis signaling pathways in pulmonary artery smooth muscle cells (PASMCs) and promoted PASMC migration and proliferation.
[Cell and Tissue Research]
Zhang, A., Yu, F., Yu, W., Ye, P., Liu, P., Gu, Y., Chen, S., & Zhang, H. (2020). Pyruvate kinase M2 activation protects against the proliferation and migration of pulmonary artery smooth muscle cells. Cell and Tissue Research. https://doi.org/10.1007/s00441-020-03245-2 Cite
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Cytokine-Induced Molecular Responses in Airway Smooth Muscle Cells Inform Genome-Wide Association Studies of Asthma

The authors revealed significant response differences between airway smooth muscle cells from asthma cases and controls, including genes implicated in asthma susceptibility.
[Genome Medicine]
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TWIST1 Drives Smooth Muscle Cell Proliferation in Pulmonary Hypertension via Loss of GATA-6 and BMPR2

In vitro, TWIST1 inhibition or silencing prevented pulmonary artery smooth muscle cell proliferation and migration.
[American Journal of Respiratory and Critical Care Medicine]
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The Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis

The authors conducted a comprehensive single-cell RNA-seq of advanced human carotid endarterectomy samples and compared these with scRNA-seq from murine micro-dissected advanced atherosclerotic lesions with smooth muscle cells.
[Circulation]
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Early Modulation of Macrophage ROS-PPARγ-NF-κB Signaling by Sonodynamic Therapy Attenuates Neointimal Hyperplasia in Rabbits

5-aminolevulinic acid-mediated sonodynamic therapy inhibited neointima formation without affecting re-endothelialization, increased blood perfusion, decreased the content of macrophages, proliferating smooth muscle cells and collagen but increased elastin by day 28.
[Scientific Reports]
Yao, J., Zhao, X., Tan, F., Cao, X., Guo, S., Li, X., Huang, Z., Diabakte, K., Wang, L., Liu, M., Shen, Z., Li, B., Cao, Z., Sheng, S., Lu, M., Cao, Y., Jin, H., Zhang, Z., & Tian, Y. (2020). Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits. Scientific Reports, 10(1), 11638. https://doi.org/10.1038/s41598-020-68543-9 Cite
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A Multi-Layered Scaffold for Regeneration of Smooth Muscle and Connective Tissue Layers

Researchers showed that within a single scaffold, the architecture supported alignment of contractile smooth muscle cells and deposition by fibroblasts of a meshwork of extracellular matrix fibrils.
[Journal of Biomedical Materials Research Part A]
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Focal Adhesion Displacement Magnitude Is a Unifying Feature of Tensional Homeostasis

Micropattern traction microscopy was used to study a wide range of FA traction forces generated by bovine vascular smooth muscle cells and bovine aortic endothelial cells cultured on substrates of stiffness of 3.6, 6.7, 13.6, and 30 kPa.
[Acta Biomaterialia]
Xu, H., Donegan, S., Dreher, J. M., Stark, A. J., Canović, E. P., Stamenović, D., & Smith, M. L. (2020). Focal adhesion displacement magnitude is a unifying feature of tensional homeostasis. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2020.06.043 Cite
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