SIRT6 Protects Vascular Smooth Muscle Cell from Osteogenic Transdifferentiation via Runx2 in Chronic Kidney Disease

SIRT6-transgenic mice showed alleviated vascular calcification (VC), while vascular smooth muscle cells-specific, SIRT6 knocked down mice showed severe VC, in chronic kidney disease.
[Journal of Clinical Investigation]
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Knockdown of Long Noncoding RNA GAS5 Reduces Vascular Smooth Muscle Cell Apoptosis by Inactivating EZH2-Mediated RIG-I Signaling Pathway in Abdominal Aortic Aneurysm

Researchers defined the role of long noncoding RNAs growth-arrest-specific transcript 5 (GAS5) in growth of smooth muscle cells and progression of abdominal aortic aneurysm .
[Journal of Translational Medicine]
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Smooth Muscle-Specific MMP17 (MT4-MMP) Regulates the Intestinal Stem Cell Niche and Regeneration after Damage

Scientists showed that smooth muscle cells might be the dominant suppliers of BMP antagonists, which are niche factors essential for intestinal stem cell maintenance.
[Nature Communications]
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Myofibre Injury Induces Capillary Disruption and Regeneration of Disorganized Microvascular Networks

Researchers defined the nature of microvascular damage and time course of repair during muscle injury and regeneration induced by the myotoxin BaCl2.
[Journal of Physiology]
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Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation

In order to discover novel endothelial-specific receptor tyrosine kinases (VEGFR)-2 TK inhibitors, scientists designed and synthesized three new series of pyridine-containing compounds. The new compounds were all screened against a panel of three cell lines.
[Oxidative Medicine and Cellular Longevity]
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HDAC8-Inhibitor PCI-34051-Induced Exosomes Inhibit Human Bronchial Smooth Muscle Cell Proliferation via miR-381-3p Mediated TGFB3

Researchers investigated the effects of PCI-34051-induced human bronchial epithelial cells-derived exosomes on human bronchial smooth muscle cells and the key exosomal miRNAs involved in this process.
[Pulmonary Pharmacology & Therapeutics]
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FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes

Using smooth muscle cells (SMCs), mouse models, and human atherosclerosis specimens, scientists found that focal adhesion kinase (FAK) activation elicited SMC dedifferentiation by stabilizing DNA methyltransferase 3A.
[Circulation Research]
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HIF-1α Promotes the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via Activation of Cx43

The authors suggested that HIF-1α, as an upstream regulator, promoted the expression of Connexin 43 (Cx43), and the HIF-1α/Cx43 axis regulated the proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.
[Journal of Cellular and Molecular Medicine]
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Circular RNA circLIFR Regulates the Proliferation, Migration, Invasion and Apoptosis of Human Vascular Smooth Muscle Cells via the miR-1299/KDR Axis

Scientists explored the detailed role and mechanism of circRNA LIF receptor subunit alpha in human umbilical artery smooth muscle cells.
[Metabolic Brain Disease]
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The Role of Vascular Smooth Muscle Cells in the Development of Aortic Aneurysms and Dissections

The authors summarize current knowledge about vascular smooth muscle cells (vSMCs) functions within the aortic wall and give an overview of how vSMC functions are dysregulated in aortic aneurysms and aortic dissections pathogenesis, organized per anatomical location.
[European Journal of Clinical Investigation]
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miR548ai Antagonism Attenuates Exosome-Induced Endothelial Cell Dysfunction

Investigators suggested that miR548ai, a rarely known microRNA, may have provided a molecular target for protection against smooth muscle cell/exosome-induced endothelial cell dysfunction.
[Cell Death Discovery]
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