Researchers report that the microRNA miR‐134‐5p potentiated inorganic phosphate‐induced calcium deposition in vascular smooth muscle cells by inhibiting histone deacetylase 5.
[Journal of Cellular and Molecular Medicine]
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The microRNA miR‐134‐5p induces calcium deposition by inhibiting histone deacetylase 5 in vascular smooth muscle cells - Choe - - Journal of Cellular and Molecular Medicine - Wiley Online Library. (n.d.). Retrieved August 13, 2020, from https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.15670 Cite
Scientists showed that the 3D culture with aligned nanofiber scaffolds, mimicing the architecture of the extracellular matrix of the heart, improved the differentiation of iPSC-cardiac progenitor cells to functional cardiomyocytes induced by Wnt inhibition, as shown with increased number of cardiac Troponin T-positive cells and synchronized intracellular Ca2+ oscillation.
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Ding, M., Andersson, H., Martinsson, S., Sabirsh, A., Jonebring, A., Wang, Q.-D., Plowright, A. T., & Drowley, L. (2020). Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells. Scientific Reports, 10(1), 13575. https://doi.org/10.1038/s41598-020-70547-4 Cite
Investigators report the existence of a communication system among human smooth muscle cells that used mechanical forces to frequency modulate long-range calcium waves.
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Scientists characterized the regional distribution of prostatic cell types in the young intact dog to enable comparisons with human and mice and they examined how the cellular source of procollagen 1A1 changes with age in intact male dogs.
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Continue reading “An Immunohistochemical Prostate Cell Identification Key Indicates that Aging Shifts Procollagen 1A1 Production from Myofibroblasts to Fibroblasts in Dogs Prone to Prostate-Related Urinary Dysfunction”
Reverse transcription polymerase chain reaction was employed to detect miR‐20a‐5p and ATP‐binding cassette subfamily A member 1 messenger RNA expression.
[Journal of Biochemical and Molecular Toxicology]
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Investigators demonstrated that pyruvate kinase M2 stimulated inflammatory and apoptosis signaling pathways in pulmonary artery smooth muscle cells (PASMCs) and promoted PASMC migration and proliferation.
[Cell and Tissue Research]
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The authors revealed significant response differences between airway smooth muscle cells from asthma cases and controls, including genes implicated in asthma susceptibility.
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In vitro, TWIST1 inhibition or silencing prevented pulmonary artery smooth muscle cell proliferation and migration.
[American Journal of Respiratory and Critical Care Medicine]
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The authors conducted a comprehensive single-cell RNA-seq of advanced human carotid endarterectomy samples and compared these with scRNA-seq from murine micro-dissected advanced atherosclerotic lesions with smooth muscle cells.
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5-aminolevulinic acid-mediated sonodynamic therapy inhibited neointima formation without affecting re-endothelialization, increased blood perfusion, decreased the content of macrophages, proliferating smooth muscle cells and collagen but increased elastin by day 28.
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Yao, J., Zhao, X., Tan, F., Cao, X., Guo, S., Li, X., Huang, Z., Diabakte, K., Wang, L., Liu, M., Shen, Z., Li, B., Cao, Z., Sheng, S., Lu, M., Cao, Y., Jin, H., Zhang, Z., & Tian, Y. (2020). Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits. Scientific Reports, 10(1), 11638. https://doi.org/10.1038/s41598-020-68543-9 Cite
Researchers showed that within a single scaffold, the architecture supported alignment of contractile smooth muscle cells and deposition by fibroblasts of a meshwork of extracellular matrix fibrils.
[Journal of Biomedical Materials Research Part A]
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Micropattern traction microscopy was used to study a wide range of FA traction forces generated by bovine vascular smooth muscle cells and bovine aortic endothelial cells cultured on substrates of stiffness of 3.6, 6.7, 13.6, and 30 kPa.
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