Exosome-Eluting Stents for Vascular Healing after Ischaemic Injury

Researchers showed that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhanced vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells.
[Nature Biomedical Engineering]
Hu, S., Li, Z., Shen, D., Zhu, D., Huang, K., Su, T., Dinh, P.-U., Cores, J., & Cheng, K. (2021). Exosome-eluting stents for vascular healing after ischaemic injury. Nature Biomedical Engineering, 1–15. https://doi.org/10.1038/s41551-021-00705-0 Cite
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Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients

Scientists investigated whether and how Piezo1 regulate the intracellular calcium homeostasis in human pulmonary arterial smooth muscle cells under normal and pulmonary arterial hypertension conditions.
[Hypertension]
Liao Jing, Lu Wenju, Chen Yuqin, Duan Xin, Zhang Chenting, Luo Xiaoyun, Lin Ziying, Chen Jiyuan, Liu Shiyun, Yan Han, Chen Yilin, Feng Huazhuo, Zhou Dansha, Chen Xu, Zhang Zizhou, Yang Qifeng, Liu Xinyi, Tang Haiyang, Li Jing, … Wang Jian. (n.d.). Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients. Hypertension, 0(0), HYPERTENSIONAHA.120.16629. https://doi.org/10.1161/HYPERTENSIONAHA.120.16629 Cite
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S1P Induces Proliferation of Pulmonary Artery Smooth Muscle Cell by Promoting YAP-Induced notch3 Expression and Activation

Investigators demonstrated that sphingosine-1-phosphate (S1P) promoted the activation of STAT3 through sphingosine-1-phosphate receptor 2, and subsequently upregulated the expression of the microRNA miR-135b, which further reduced the expression of E3 ubiquitin ligase β-transduction repeat-containing protein and led to a reduction in YAP ubiquitinated degradation in pulmonary artery smooth muscle cell.
[Journal of Biological Chemistry]
Wang, J., Yan, X., Feng, W., Wang, Q., Shi, W., Chai, L., Zhang, Q., Chen, Y., Liu, J., Qu, Z., Xie, X., & Li, M. (2021). S1P induces proliferation of pulmonary artery smooth muscle cell by promoting YAP-induced Notch3 expression and activation. Journal of Biological Chemistry, 0(0). https://doi.org/10.1016/j.jbc.2021.100599 Cite
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The Origin and Mechanisms of Smooth Muscle Cell Development in Vertebrates

Scientists describe the developmental origin of smooth muscle cells within different tissues by comparing their specification and differentiation with other organs, including the cardiovascular, respiratory and intestinal systems. They also discuss the instructive roles of smooth muscle in the development of such organs through signaling and mechanical feedback mechanisms.
[Development]
Donadon, M., & Santoro, M. M. (2021). The origin and mechanisms of smooth muscle cell development in vertebrates. Development, 148(7). https://doi.org/10.1242/dev.197384 Cite
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Exosome-Eluting Stents for Vascular Healing after Ischemic Injury

The authors showed that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells.
[Nature Biomedical Engineering]
Hu, S., Li, Z., Shen, D., Zhu, D., Huang, K., Su, T., Dinh, P.-U., Cores, J., & Cheng, K. (2021). Exosome-eluting stents for vascular healing after ischaemic injury. Nature Biomedical Engineering, 1–15. https://doi.org/10.1038/s41551-021-00705-0 Cite
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The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells

The authors discussed the Ca2+ entry pathways at the plasma membrane, Ca2+ released signals from the intracellular stores, the functional and physiological relevance of Ca2+ signals, and their regulatory mechanisms.
[Comprehensive Physiology]
Ottolini, M., & Sonkusare, S. K. (2021). The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells. In Comprehensive Physiology (pp. 1831–1869). American Cancer Society. https://doi.org/10.1002/cphy.c200030 Cite
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GDF11 Prevents the Formation of Thoracic Aortic Dissection in Mice: Promotion of Contractile Transition of Aortic SMCs

Researchers investigated the expression of GDF11 in thoracic aortic dissection and its effects on aortic smooth muscle cell phenotype transition.
[Journal of Cellular and Molecular Medicine]
Ren, K., Li, B., Liu, Z., Xia, L., Zhai, M., Wei, X., Duan, W., & Yu, S. (n.d.). GDF11 prevents the formation of thoracic aortic dissection in mice: Promotion of contractile transition of aortic SMCs. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16312 Cite
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Promyelocytic Leukemia Protein (PML) Promotes the Phenotypic Switch of Smooth Muscle Cells in Atherosclerotic Plaques of Human Coronary Arteries

To identify possible functional consequences of PML-accumulation, differentiated human coronary artery smooth muscle cells were transfected with a vector containing the intact PML-gene.
[Clinical Science]
Karle, W., Becker, S., Stenzel, P., Knosalla, C., Siegel, G., Baum, O., Zakrzewicz, A., & Berkholz, J. (2021). Promyelocytic leukemia protein (PML) promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries. Clinical Science, CS20201399. https://doi.org/10.1042/CS20201399 Cite
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Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and their Myogenic Progeny in Vascular Lesions

Researchers evaluated single cell photonics as a discriminator of cell phenotype in vitro before the presence of vascular stem cells within vascular lesions.
[Stem Cell Reviews and Reports]
Molony, C., King, D., Di Luca, M., Kitching, M., Olayinka, A., Hakimjavadi, R., Julius, L. A. N., Fitzpatrick, E., Gusti, Y., Burtenshaw, D., Healy, K., Finlay, E. K., Kernan, D., Llobera, A., Liu, W., Morrow, D., Redmond, E. M., Ducrée, J., & Cahill, P. A. (2021). Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and their Myogenic Progeny in Vascular Lesions. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10125-x Cite
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NG2/CSPG4, CD146/MCAM and VAP1/AOC3 Are Regulated by Myocardin-Related Transcription Factors in Smooth Muscle Cells

Overexpression of myocardin-related transcription factors increased both mRNA and protein levels of CSPG4, MCAM, and AOC3 in cultured human smooth muscle cells.
[Scientific Reports]
Rippe, C., Morén, B., Liu, L., Stenkula, K. G., Mustaniemi, J., Wennström, M., & Swärd, K. (2021). NG2/ CSPG4 , CD146/ MCAM and VAP1/ AOC3 are regulated by myocardin-related transcription factors in smooth muscle cells. Scientific Reports, 11(1), 5955. https://doi.org/10.1038/s41598-021-85335-x Cite
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Prime Editing in Mice Reveals the Essentiality of a Single Base in Driving Tissue-Specific Gene Expression

Immuno-RNA fluorescence in situ hybridization validated loss of Tspan2 in vascular smooth muscle cells of HDR and PE2 CArG box mutant mice.
[Genome Biology]
Gao, P., Lyu, Q., Ghanam, A. R., Lazzarotto, C. R., Newby, G. A., Zhang, W., Choi, M., Slivano, O. J., Holden, K., Walker, J. A., Kadina, A. P., Munroe, R. J., Abratte, C. M., Schimenti, J. C., Liu, D. R., Tsai, S. Q., Long, X., & Miano, J. M. (2021). Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression. Genome Biology, 22(1), 83. https://doi.org/10.1186/s13059-021-02304-3 Cite
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