Inhibition of eNOS by L-NAME Resulting in Rat Hind Limb Developmental Defects through PFKFB3 Mediated Angiogenetic Pathway

In vivo studies showed that NOS inhibition strongly suppressed hind limb angiogenetic remodeling by impairing differentiation of endothelial cells and smooth muscle cells, and extracellular matrix synthesis.
[Scientific Reports]
Wu, Z., Yao, H., Xu, H., Wang, Y., Hu, W., Lou, G., Zhang, L., Huang, C., Jiang, C., Zhou, S., Shi, Y., Chen, X., Yang, L., Xu, Y., & Wang, Y. (2020). Inhibition of eNOS by L-NAME resulting in rat hind limb developmental defects through PFKFB3 mediated angiogenetic pathway. Scientific Reports, 10(1), 16754. https://doi.org/10.1038/s41598-020-74011-1 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Inhibition of eNOS by L-NAME Resulting in Rat Hind Limb Developmental Defects through PFKFB3 Mediated Angiogenetic Pathway

In vivo studies showed that NOS inhibition strongly suppressed hind limb angiogenetic remodeling by impairing differentiation of endothelial cells and smooth muscle cells, and extracellular matrix synthesis.
[Scientific Reports]
Wu, Z., Yao, H., Xu, H., Wang, Y., Hu, W., Lou, G., Zhang, L., Huang, C., Jiang, C., Zhou, S., Shi, Y., Chen, X., Yang, L., Xu, Y., & Wang, Y. (2020). Inhibition of eNOS by L-NAME resulting in rat hind limb developmental defects through PFKFB3 mediated angiogenetic pathway. Scientific Reports, 10(1), 16754. https://doi.org/10.1038/s41598-020-74011-1 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cell

Using three complementary mouse models of carotid artery injury, researchers demonstrated that both tamoxifen and estradiol accelerated endothelial healing, but only tamoxifen required the presence of the underlying medial smooth muscle cells.
[Circulation Research]
Zahreddine Rana, Davezac Morgane, Smirnova Natalia F, Buscato Mélissa, Lhuillier Emeline, Lupieri Adrien, Solinhac Romain, Vinel Alexia, Vessieres Emilie, Henrion Daniel, Renault Marie-Ange, Gadeau Alain-Pierre, Flouriot Gilles, Lenfant Francoise, Laffargue Muriel, Metivier Raphael, Arnal Jean-Francois, & Fontaine Coralie. (n.d.). Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cell. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317062 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Direct Extrusion of Individually Encapsulated Endothelial and Smooth Muscle Cells Mimicking Blood Vessel Structures and Vascular Native Cell Alignment

Prior to extrusion, the innermost cell encapsulating hydrogel was loaded with HUVECs, whereas the outer hydrogel was loaded with human aortic smooth muscle cells.
[Biofabrication]
Rué, E. B., Delgado, L. M., Gil, F. J., & Perez, R. A. (2020). Direct extrusion of individually encapsulated endothelial and smooth muscle cells mimicking blood vessel structures and vascular native cell alignment. Biofabrication. https://doi.org/10.1088/1758-5090/abbd27 Cite
AbstractFull Article
Bookmark

No account yet? Register

0
Share

hsa_circNFXL1_009 Modulates Apoptosis, Proliferation, Migration, and Potassium Channel Activation in Pulmonary Hypertension

The authors explored the circular RNA profile in pulmonary arterial hypertension patients caused by chronic obstructive pulmonary disease and the effects of hsa_circNFXL1_009 on abnormal proliferation, apoptosis, and migration of human pulmonary arterial smooth muscle cells driven by hypoxia.
[Molecular Therapy-Nucleic Acids]
Jin, X., Xu, Y., Guo, M., Sun, Y., Ding, J., Li, L., Zheng, X., Li, S., Yuan, D., & Li, S.-S. (2020). hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.029 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

miR-27a-3p Targets ATF3 to Reduce Calcium Deposition in Vascular Smooth Muscle Cells

Scientists report that reduction of microRNA-27a-3p causes an increase in ATF3, activating transcription factor 3, a novel osteogenic transcription factor, in vascular smooth muscle cells.
[Molecular Therapy-Nucleic Acids]
Choe, N., Kwon, D.-H., Ryu, J., Shin, S., Cho, H. J., Joung, H., Eom, G. H., Ahn, Y., Park, W. J., Nam, K.-I., Kim, Y.-K., & Kook, H. (2020). miR-27a-3p targets ATF3 to reduce calcium deposition in vascular smooth muscle cells. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.030 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Circular RNA CDR1as Promotes Pulmonary Artery Smooth Muscle Cell Calcification by Upregulating CAMK2D and CNN3 via Sponging miR-7-5p

Scientists investigated the implication and regulatory effect of a typical circular RNA, CDR1as, in the pathological process of vascular calcification in pulmonary hypertension.
[Molecular Therapy-Nucleic Acids]
Ma, C., Gu, R., Wang, X., He, S., Bai, J., Zhang, L., Zhang, J., Li, Q., Qu, L., Xin, W., Jiang, Y., Li, F., Zhao, X., & Zhu, D. (2020). Circular RNA CDR1as promotes pulmonary artery smooth muscle cell calcification by upregulating CAMK2D and CNN3 via sponging miR-7-5p. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.018 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Single-Cell Genomics Reveals a Novel Cell State during Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

To reveal the trajectories of smooth muscle cell (SMC) transdifferentiation during atherosclerosis and to identify molecular targets for disease therapy, researchers combined SMC fate mapping and single-cell RNA sequencing of both mouse and human atherosclerotic plaques.
[Circulation]
Pan Huize, Xue Chenyi, Auerbach Benjamin J., Fan Jiaxin, Bashore Alexander C., Cui Jian, Yang Dina Y., Trignano Sarah B., Liu Wen, Shi Jianting, Ihuegbu Chinyere O., Bush Erin C., Worley Jeremy, Vlahos Lukas, Laise Pasquale, Solomon Robert A., Connolly Edward S., Califano Andrea, Sims Peter A., … Reilly Muredach P. (n.d.). Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.120.048378 Cite
Abstract
Bookmark

No account yet? Register

0
Share

BCAT1 Binds the RNA-Binding Protein ZNF423 to Activate Autophagy via the IRE1-XBP-1-RIDD Axis in Hypoxic PASMCs

Scientists discovered that BCAT1 bound IRE1 on the endoplasmic reticulum to activate expression of its downstream pathway XBP-1-RIDD axis to activate autophagy. They identified an RNA-binding protein, zinc finger protein 423, which promoted autophagy by binding adenylate/uridylate-rich elements in the BCAT1 mRNA 3′-untranslated region.
[Cell Death & Disease]
Xin, W., Zhang, M., Yu, Y., Li, S., Ma, C., Zhang, J., Jiang, Y., Li, Y., Zheng, X., Zhang, L., Zhao, X., Pei, X., & Zhu, D. (2020). BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XBP-1-RIDD axis in hypoxic PASMCs. Cell Death & Disease, 11(9), 1–16. https://doi.org/10.1038/s41419-020-02930-y Cite
Full Article
Bookmark

No account yet? Register

0
Share

Activation of M3AchR (Type 3 Muscarinic Acetylcholine Receptor) and Nrf2 (Nuclear Factor Erythroid 2–Related Factor 2) Signaling by Choline Alleviates Vascular Smooth Muscle Cell Phenotypic Switching and Vascular Remodeling

Researchers investigated whether choline modulates vascular smooth muscle cell phenotypic changes and explored the underlying mechanisms.
[Arteriosclerosis Thrombosis and Vascular Biology]
He Xi, Deng Juan, Yu Xiao-Jiang, Yang Si, Yang Yang, & Zang Wei-Jin. (n.d.). Activation of M3AchR (Type 3 Muscarinic Acetylcholine Receptor) and Nrf2 (Nuclear Factor Erythroid 2–Related Factor 2) Signaling by Choline Alleviates Vascular Smooth Muscle Cell Phenotypic Switching and Vascular Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology, 0(0), ATVBAHA.120.315146. https://doi.org/10.1161/ATVBAHA.120.315146 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Chitinase-3 Like-Protein-1 Function and Its Role in Diseases

Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) binds to chitin, heparin, and hyaluronic acid, and is regulated by ECM changes, cytokines, growth factors, drugs, and stress. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.
[Signal Transduction and Targeted Therapy]
Zhao, T., Su, Z., Li, Y., Zhang, X., & You, Q. (2020). Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduction and Targeted Therapy, 5(1), 1–20. https://doi.org/10.1038/s41392-020-00303-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share