The authors found that HOPS enhanced NF-κB activation leading to increase transcription of inflammatory mediators, through the reduction of IκBα stability.
[Cell Death & Disease]
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HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6 | Cell Death & Disease. (n.d.). Retrieved October 16, 2020, from https://www.nature.com/articles/s41419-020-03086-5#Abs1 Cite
Researchers investigated the mechanism underneath MSC-reversed lung injury and fibrosis. They determined that coculture with MSC led to the inactivation of NF-κB signaling and therefore suppressed the hedgehog pathway in LPS-treated MLE-12 cells.
[Cell Death & Disease]
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Xiao, K., He, W., Guan, W., Hou, F., Yan, P., Xu, J., Zhou, T., Liu, Y., & Xie, L. (2020). Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury. Cell Death & Disease, 11(10), 1–17. https://doi.org/10.1038/s41419-020-03034-3 Cite
The authors’ in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells.
[Experimental and Molecular Medicine]
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The authors describe a mechanism underlying the regulation of programmed cell death-1 (PD-1) at the mRNA level and demonstrated its impact on T-cell dysfunction. Transcriptomic analysis identified a correlation between transforming growth factor beta 1 and PDCD1 in clear cell renal cell carcinoma samples.
[Cancer Immunology Research]
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Wu, P., Geng, B., Chen, Q., Zhao, E., Liu, J., Sun, C., Zha, C., Shao, Y., You, B., Zhang, W., Li, L., Meng, X., Cai, J., & Li, X. (2020). Tumor cell-derived TGFβ1 Attenuates Antitumor Immune Activity of T cells via Regulation of PD-1 mRNA. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0113 Cite
Investigators revealed that protein arginine methyltransferase 5 catalyzes methylation of Y-box binding protein 1 (YBX1) at arginine 205, an event that is critical for YBX1-mediated nuclear factor κB activation and its downstream target gene expression.
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Scientists investigated the anticancer effects of botanical component p-hydroxycinnamic acid on the PC-3 cells in vitro model of bone metastatic human prostate cancer.
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Scientists investigated the radioprotective effects and the underlying mechanism of the standardized herbal extract PM014 on radiation-induced lung fibrosis.
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Methanol extracts of carrot root were purified by means of silica gel, Sephadex LH-20, and preparative high-performance liquid chromatography to isolate a compound targeting mammosphere formation.
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Scientists showed that procyanidin B2 could repress oxidative stress via nuclear factor-erythroid 2-related factor 2/ARE signaling and then promote intestine injury repair.
[Antioxidants & Redox Signaling]
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Procyanidin B2 promotes intestinal injury repair and attenuates colitis-associated tumorigenesis via suppression of oxidative stress in mouse | Antioxidants & Redox Signaling. (n.d.). Retrieved September 18, 2020, from https://www.liebertpub.com/doi/10.1089/ars.2019.7911 Cite
Researchers characterized NOTCH signaling in macrophages activated by Toll-like receptor triggering and determined that DLL1 and DLL4 were the main ligands responsible for NOTCH signaling.
Non-small cell lung cancer cells were pre-treated with mitomycin C (MMC) and then co-cultured with peripheral blood mononuclear cells to investigate the effect of the combination of MMC with PD-L1 antibody.
[Signal Transduction and Targeted Therapy]
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