Substrate-Specific Recognition of IKKs Mediated by USP16 Facilitates Autoimmune Inflammation

Investigators found that IKKβ ubiquitination on lysine-238 was substantially increased during inflammation. Using mass spectrometry, they identified USP16 as an essential regulator of the IKKβ ubiquitination level that selectively affected p105 phosphorylation without directly affecting p65 or IκBα phosphorylation.
[Science Advances]
Substrate-specific recognition of IKKs mediated by USP16 facilitates autoimmune inflammation | Science Advances. (n.d.). Retrieved January 22, 2021, from https://advances.sciencemag.org/content/7/3/eabc4009 Cite
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miR-558 Reduces the Damage of HBE Cells Exposed to Cigarette Smoke Extract by Targeting TNFRSF1A and Inactivating TAK1/MAPK/NF-κB Pathway

Up-regulation of miR-558 alleviated cigarette smoke extract (CSE)-induced damage on HBE cells. The alleviative effect of miR-558 mimic on CSE-induced damage was suppressed by miR-558/TNF receptor superfamily member 1A (TNFRSF1A) overexpression.
[Immunological Investigations]
Jing, X., Luan, Z., & Liu, B. (2021). miR-558 Reduces the Damage of HBE Cells Exposed to Cigarette Smoke Extract by Targeting TNFRSF1A and Inactivating TAK1/MAPK/NF-κB Pathway. Immunological Investigations, 0(0), 1–15. https://doi.org/10.1080/08820139.2021.1874977 Cite
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Late p65 Nuclear Translocation in Glioblastoma Cells Indicates Non-Canonical TLR4 Signaling and Activation of DNA Repair Genes

Scientists analyzed Toll-like receptor 4 (TLR4) expression in different grades of astrocytoma, and observed increased expression in tumors, mainly in glioblastoma, compared to non-neoplastic brain tissue.
[Scientific Reports]
Moretti, I. F., Lerario, A. M., Trombetta-Lima, M., Sola, P. R., da Silva Soares, R., Oba-Shinjo, S. M., & Marie, S. K. N. (2021). Late p65 nuclear translocation in glioblastoma cells indicates non-canonical TLR4 signaling and activation of DNA repair genes. Scientific Reports, 11(1), 1333. https://doi.org/10.1038/s41598-020-79356-1 Cite
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Small Extracellular Vesicles from Adipose Derived Stromal Cells Significantly Attenuate In Vitro the Nf-κB Dependent Inflammatory/Catabolic Environment of Osteoarthritis

Researchers investigated the effects of small extracellular vesicles from adipose derived stromal cells on both chondrocytes and synoviocytes, in order to gain insights into the mechanisms modulating the inflammatory/catabolic osteoarthritis environment.
[Scientific Reports]
Cavallo, C., Merli, G., Borzì, R. M., Zini, N., D’Adamo, S., Guescini, M., Grigolo, B., Di Martino, A., Santi, S., & Filardo, G. (2021). Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-κB dependent inflammatory/catabolic environment of osteoarthritis. Scientific Reports, 11(1), 1053. https://doi.org/10.1038/s41598-020-80032-7 Cite
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Ameliorate Airway Inflammation in a Rat Model of Chronic Obstructive Pulmonary Disease (COPD)

The authors assessed the potential anti-inflammatory effects of human umbilical cord MSC-derived extracellular vesicles in a rat model of chronic obstructive pulmonary disease.
[Stem Cell Research & Therapy]
Ridzuan, N., Zakaria, N., Widera, D., Sheard, J., Morimoto, M., Kiyokawa, H., Mohd Isa, S. A., Chatar Singh, G. K., Then, K.-Y., Ooi, G.-C., & Yahaya, B. H. (2021). Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD). Stem Cell Research & Therapy, 12(1), 54. https://doi.org/10.1186/s13287-020-02088-6 Cite
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MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

Scientists found that SARS-CoV-2 replication induced a delayed interferon response in lung epithelial cells. By screening 16 putative sensors involved in sensing of RNA virus infection, they found that MDA5 and LGP2 primarily regulated IFN induction in response to SARS-CoV-2 infection.
[Cell Reports]
Yin, X., Riva, L., Pu, Y., Martin-Sancho, L., Kanamune, J., Yamamoto, Y., Sakai, K., Gotoh, S., Miorin, L., Jesus, P. D. D., Yang, C.-C., Herbert, K. M., Yoh, S., Hultquist, J. F., García-Sastre, A., & Chanda, S. K. (2021). MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells. Cell Reports, 34(2). https://doi.org/10.1016/j.celrep.2020.108628 Cite
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Nuclear Factor Kappa B Activation in Cardiomyocytes by Serum of Children with Obstructive Sleep Apnea Syndrome

Researchers hypothesized that obstructive sleep apnea syndrome (OSA) children’s serum can activate NFκB in cardiomyocytes (CM) and effect their viability. In order to explore the role played by NFκB in OSA cardiovascular pathophysiology, rat, mouse and human immortalized CM were exposed to human serum drawn from OSA children and matched controls.
[Scientific Reports]
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Progression-Free Survival of Prostate Cancer Patients Is Prolonged with a Higher Regucalcin Expression in the Tumor Tissues: Overexpressed Regucalcin Suppresses the Growth and Bone Activity in Human Prostate Cancer Cells

Overexpression of regucalcin in bone metastatic human prostate cancer PC-3 and DU-145 cells suppressed colony formation and cell growth in vitro. Overexpressed regucalcin enhanced the levels of p53, Rb, and p21, and decreased the levels of Ras, PI3 kinase, Akt, and mitogen-activated protein kinase, leading to suppression of cell growth.
[Translational Oncology]
Yamaguchi, M., Osuka, S., Murata, T., & Ramos, J. W. (2021). Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells. Translational Oncology, 14(1), 100955. https://doi.org/10.1016/j.tranon.2020.100955 Cite
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Role of RPTPβ/ζ in Neuroinflammation and Microglia-Neuron Communication

Investigators tested if RPTPβ/ζ was involved in the modulation of neuroinflammatory responses using specific inhibitors of RPTPβ/ζ.
[Scientific Reports]
Fernández-Calle, R., Galán-Llario, M., Gramage, E., Zapatería, B., Vicente-Rodríguez, M., Zapico, J. M., de Pascual-Teresa, B., Ramos, A., Ramos-Álvarez, M. P., Uribarri, M., Ferrer-Alcón, M., & Herradón, G. (2020). Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Scientific Reports, 10(1), 20259. https://doi.org/10.1038/s41598-020-76415-5 Cite
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Scutellarin Ameliorates Pulmonary Fibrosis through Inhibiting NF-κB/NLRP3-Mediated Epithelial–Mesenchymal Transition and Inflammation

Investigators discovered that scutellarin suppressed inflammation and epithelial–mesenchymal transition in BLM-induced pulmonary fibrosis through NF-κB/NLRP3 signaling.
[Cell Death & Disease]
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation | Cell Death & Disease. (n.d.). Retrieved November 19, 2020, from https://www.nature.com/articles/s41419-020-03178-2 Cite
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Cytochrome P450 1A2 Overcomes Nuclear Factor Kappa B-Mediated Sorafenib Resistance in Hepatocellular Carcinoma

To investigate whether CYP1A2 and NF‐κB p65 played roles in sorafenib desensitization, the authors established sorafenib-resistant (SR) HCC cells. SR cells decreased the expression of CYP1A2 along with the upregulation of NF‐κB p65.
[Oncogene]
Yu, J., Wang, N., Gong, Z., Liu, L., Yang, S., Chen, G. G., & Lai, P. B. S. (2020). Cytochrome P450 1A2 overcomes nuclear factor kappa B-mediated sorafenib resistance in hepatocellular carcinoma. Oncogene, 1–16. https://doi.org/10.1038/s41388-020-01545-z Cite
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