smooth muscle cells

[Oxidative Medicine and Cellular Longevity] Scientists determined vascular aging due to DNA damage in vascular smooth muscle cells, as achieved by smooth muscle-selective genetic removal of ERCC1 DNA repair in mice.

[Molecular Medicine Reports] Researchers investigated the detailed role of nuclear paraspeckle assembly transcript 1 (NEAT1) in pulmonary arterial hypertension (PAH). Using RT‑qPCR, the expression levels of NEAT1, microRNA (miR)‑34a‑5p, and Krüppel‑like factor 4 were detected in both hypoxia‑treated pulmonary arterial smooth muscle cells and serum from PAH patients.

[Biochemical and Biophysical Research Communications] THP-1/oxidized low-density lipoprotein (ox-LDL) Exo significantly increased the expression levels of CDK2 and proliferative cell nuclear antigen in human vascular smooth muscle cells, while these effects were reversed following LIPCAR silencing.

[Respiratory Research] Researchers explored the role of tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) in the regulation of airway smooth muscle cells, which are one of the main effector cells in the development of asthma.

[Journal of Molecular and Cellular Cardiology] To emphasize the relationship between senescent cells and vascular aging, investigators summarize the roles of senescent vascular cells in the vascular aging process and inducers that contribute to cellular senescence.

[Oxidative Medicine and Cellular Longevity] The authors investigated the effects of silencing salusin-β on endothelial function, cardiac function, vascular and myocardial remodeling, and its underlying signaling pathways in chronic heart failure rats induced by coronary artery ligation.