smooth muscle cells

[Journal of Cell Science] Human umbilical vein endothelial cells (HUVECs) elongated, activated TAGLN promoter and increased TAGLN transcripts in angiogenesis model. Genetic disruption of TAGLN augmented angiogenic behaviors of HUVECs, as did the disruption of TAGLN2 and TAGLN3 genes.

[Thorax] Pharmacological inhibition of checkpoint kinases 1 and 2 using LY2606368 attenuated fibrosis and pulmonary vascular remodeling, leading to improvement in respiratory mechanics and hemodynamic parameters in two animal models mimicking idiopathic pulmonary fibrosis (IPF) and IPF+pulmonary hypertension.

[Scientific Reports] The authors investigated the effect of all-trans-retinoic acid, a modulator of smooth muscle cell functions, on coronary artery stenosis in a mouse model of Kawasaki disease.

[Chembiochem] Scientists constructed a cell-based luciferase assay system for HIF-1 inhibitors and used this system to identify six HIF-1 inhibitors. Among these inhibitors, the effect of tagitinin C (1) on pulmonary arterial smooth muscle cells was investigated.

[Thrombosis and Haemostasis] Researchers examined the influence of endothelial progenitor cells on features of smooth muscle cells pivotal for their impact on injury-induced neointima formation including proliferation, migration, and phenotype switch.

[Molecular Medicine Reports] The authors investigated the roles of microRNA‑199a‑5p in varicose veins and in the phenotypic transition of vascular smooth muscle cells.