TAGLN, a Canonical Marker of Smooth Muscle Cells, Is Present in Endothelial Cells and Involved in Angiogenesis

Human umbilical vein endothelial cells (HUVECs) elongated, activated TAGLN promoter and increased TAGLN transcripts in angiogenesis model. Genetic disruption of TAGLN augmented angiogenic behaviors of HUVECs, as did the disruption of TAGLN2 and TAGLN3 genes.