Tag Archives: VEGF

SDF-1α Gene-Activated Collagen Scaffold Drives Functional Differentiation of Human Schwann Cells for Wound Healing Applications

Researchers explored the role of a collagen‐chondroitin sulfate scaffold functionalized with a pro‐angiogenic gene stromal‐derived factor‐1 alpha (SDF‐1α) – an SDF‐1α gene‐activated scaffold on the functional regulation of human Schwann cells.
[Biotechnology and Bioengineering]
Laiva, A. L., O’Brien, F. J., & Keogh, M. B. (n.d.). SDF-1α gene-activated collagen scaffold drives functional differentiation of human Schwann cells for wound healing applications. Biotechnology and Bioengineering, n/a(n/a). https://doi.org/10.1002/bit.27601 Cite
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Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon

Researchers showed that nascent blood vessels actively contacted dividing neural stem cells by endothelial filopodia in the ventricular zone (VZ) of the murine ventral telencephalon; this association was conserved in the human ventral VZ.
[Cell Reports]
Marco, B. D., Crouch, E. E., Shah, B., Duman, C., Paredes, M. F., Almodovar, C. R. de, Huang, E. J., & Alfonso, J. (2020). Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Reports, 33(2). https://doi.org/10.1016/j.celrep.2020.108256 Cite
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Osteocyte Vegf-A Contributes to Myeloma-Associated Angiogenesis and Is Regulated by Fgf23

Hypoxia and/or co-culture with multiple myeloma (MM) cells significantly increased Vegf-a expression in MLOA5-Ocys, and conditioned media (CM) from MLOA5s or MM-MLOA5 co-cultured in hypoxia, significantly increased endothelial tube length compared to normoxic CM.
[Scientific Reports]
Mulcrone, P. L., Edwards, S. K. E., Petrusca, D. N., Haneline, L. S., Delgado-Calle, J., & Roodman, G. D. (2020). Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23. Scientific Reports, 10(1), 17319. https://doi.org/10.1038/s41598-020-74352-x Cite
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Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Pathological Retinal Angiogenesis by Suppressing Vascular Endothelial Growth Factor-Induced Arf6 Activation

Scientists examined the effects of evogliptin, a potent DPP-4 inhibitor, on pathological retinal neovascularization in mice and elucidated the mechanism by which evogliptin inhibits angiogenesis mediated by VEGF, a key factor in the vascular pathogenesis of proliferative diabetic retinopathy
[Experimental and Molecular Medicine]
Seo, S., Kim, M.-K., Kim, R.-I., Yeo, Y., Kim, K. L., & Suh, W. (2020). Evogliptin, a dipeptidyl peptidase-4 inhibitor, attenuates pathological retinal angiogenesis by suppressing vascular endothelial growth factor-induced Arf6 activation. Experimental & Molecular Medicine, 1–10. https://doi.org/10.1038/s12276-020-00512-8 Cite
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis

Researchers found that human umbilical cord MSCs-derived small extracellular vesicles were successfully absorbed by lung tissue after intratracheal administration, and remained in the lungs for at least 72 hours.
[Stem Cells and Development]
You, J., Zhou, O., Liu, J., Zou, W., Zhang, L., Tian, D., Dai, J., Luo, Z., Liu, E., Fu, Z., & Zou, L. (2020). Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0156 Cite
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Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalo

Scientists showed that nascent blood vessels actively contact dividing neural stem cells by endothelial filopodia in the ventricular zone (VZ) of the murine ventral telencephalon; this association was conserved in the human ventral VZ.
[Cell Reports]
Marco, B. D., Crouch, E. E., Shah, B., Duman, C., Paredes, M. F., Almodovar, C. R. de, Huang, E. J., & Alfonso, J. (2020). Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Reports, 33(2). https://doi.org/10.1016/j.celrep.2020.108256 Cite
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Therapeutic Angiogenesis Using Autologous Adipose-Derived Regenerative Cells in Patients with Critical Limb Ischaemia in Japan: A Clinical Pilot Study

Adipose tissue was obtained by ordinary liposuction method. Isolated ADRCs were injected into the ischaemic limb. Scientists performed TACT-ADRC procedure in five patients with CLI.
[Scientific Reports]
Therapeutic angiogenesis using autologous adipose-derived regenerative cells in patients with critical limb ischaemia in Japan: a clinical pilot study | Scientific Reports. (n.d.). Retrieved October 5, 2020, from https://www.nature.com/articles/s41598-020-73096-y Cite
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Ablation of Neuropilin-1 Improves the Therapeutic Response in Conventional Drug-Resistant Glioblastoma Multiforme

Scientists observed that patient-derived glioblastoma cells expressing shRNAs of VEGF or neuropilin-1 attenuated cancer stem cell markers, inhibited the tumor-initiating cell’s neurosphere-forming capacity, and migration.
[Oncogene]
Angom, R. S., Mondal, S. K., Wang, F., Madamsetty, V. S., Wang, E., Dutta, S. K., Gulani, Y., Sarabia-Estrada, R., Sarkaria, J. N., Quiñones-Hinojosa, A., & Mukhopadhyay, D. (2020). Ablation of neuropilin-1 improves the therapeutic response in conventional drug-resistant glioblastoma multiforme. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01462-1 Cite
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RNA N6-Methyladenosine Reader IGF2BP3 Regulates Cell Cycle and Angiogenesis in Colon Cancer

The expression of m6A associated enzymes and total m6A level were measured by Western Blotting analysis and m6A RNA Methylation Quantification Kit respectively. Cell cycle was analyzed by flowcytometry. The interaction of IGF2BP3 and related targets was analyzed by RNA immunoprecipitation and m6A RNA immunoprecipitation assays.
[Journal of Experimental & Clinical Cancer Research]
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Heterogeneity in VEGF Receptor-2 Mobility and Organization on the Endothelial Cell Surface Leads to Diverse Models of Activation by VEGF

Researchers found that surface VEGFR-2 could be mobile or exhibit restricted mobility and be monomeric or non-monomeric, with a complex interplay between the two.
[Cell Reports]
Rocha-Azevedo, B. da, Lee, S., Dasgupta, A., Vega, A. R., Oliveira, L. R. de, Kim, T., Kittisopikul, M., Malik, Z. A., & Jaqaman, K. (2020). Heterogeneity in VEGF Receptor-2 Mobility and Organization on the Endothelial Cell Surface Leads to Diverse Models of Activation by VEGF. Cell Reports, 32(13). https://doi.org/10.1016/j.celrep.2020.108187 Cite
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12-O-Tetradecanoylphorbol-13-Acetate Increases Cardiomyogenesis through PKC/ERK Signaling

Scientists showed that 12-O-tetradecanoylphorbol-13-acetate can be applied as a cardiomyogenesis-promoting factor for the differentiation of mouse embryonic stem cells in vitro.
[Scientific Reports]
Radaszkiewicz, K. A., Beckerová, D., Woloszczuková, L., Radaszkiewicz, T. W., Lesáková, P., Blanářová, O. V., Kubala, L., Humpolíček, P., & Pachernik, J. (2020). 12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling. Scientific Reports, 10(1), 15922. https://doi.org/10.1038/s41598-020-73074-4 Cite
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