Investigators found that PKH26-labeled human amniotic epithelial cells mainly distributed in the basal layer of endometrium after transplantation.
[Stem Cells and Development]
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The three dihydroxystilbenes in this study inhibited colon carcinogenesis and tumor growth as well as increases in colon IL-1β, IL-6, MCP-1, and PD-1 levels in AOM/DDS-treated mice in vivo. The three dihydroxystilbenes also suppressed COX-2 expression in colon tumors in vivo and inhibited PD-1 elevations in M2-THP-1 macrophages in vitro.
[European Journal of Pharmacology]
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Kimura, Y., Sumiyoshi, M., Kiyoi, T., & Baba, K. (2020). Dihydroxystilbenes prevent azoxymethane/dextran sulfate sodium-induced colon cancer by inhibiting colon cytokines, a chemokine, and programmed cell death-1 in C57BL/6J mice. European Journal of Pharmacology, 173445. https://doi.org/10.1016/j.ejphar.2020.173445 Cite
Scientists determined the effects of grape antioxidants quercetin and/or resveratrol against prostate cancer in the transgenic adenocarcinoma of mouse prostate (TRAMP)-model in prevention and intervention settings.
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Investigators evaluated the effects of human bone marrow (hBM)-conditioned medium derived from different stages of hBM MSC culture on the osteogenic capacity of perivascular tissue of the human umbilical cord.
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Deep high-throughput sequencing approach allowed researchers to analyze the miRNA and mRNA expression profiles in HUVECS cultured under gravity, and stimulated microgravity achieved with a clinostat.
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Kasiviswanathan, D., Chinnasamy Perumal, R., Bhuvaneswari, S., Kumar, P., Sundaresan, L., Philip, M., Puthenpurackal Krishnankutty, S., & Chatterjee, S. (2020). Interactome of miRNAs and transcriptome of human umbilical cord endothelial cells exposed to short-term simulated microgravity. Npj Microgravity, 6(1), 1–10. https://doi.org/10.1038/s41526-020-00108-6 Cite
Investigators showed that plasma polymerized nanoparticles, synthesised in reactive gas discharges, could bind and effectively deliver multiple therapeutic cargo in a facile and cost-effective process compatible with up scaled commercial production.
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Michael, P., Lam, Y. T., Filipe, E. C., Tan, R. P., Chan, A. H. P., Lee, B. S. L., Feng, N., Hung, J., Cox, T. R., Santos, M., & Wise, S. G. (2020). Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo. Scientific Reports, 10(1), 12836. https://doi.org/10.1038/s41598-020-69591-x Cite
Researchers overexpressed pigment epithelium-derived factor (PEDF) in placenta-derived mesenchymal stem cells (PD-MSCsPEDF) using a nonviral gene delivery system and evaluated the characteristics of PD-MSCsPEDF and their potential regenerative effects on retinal pigment epithelial cells damaged by H2O2-induced oxidative stress.
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Kim, J. Y., Park, S., Park, S. H., Lee, D., Kim, G. H., Noh, J. E., Lee, K. J., & Kim, G. J. (2020). Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells. Laboratory Investigation, 1–19. https://doi.org/10.1038/s41374-020-0470-z Cite
Using in vitro experiments, investigators found that anlotinib had significant effects on proliferation inhibition, migration and invasion restraint, and cell-cycle arrestment in intrahepatic cholangiocarcinoma.
[Cell Death & Disease]
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Song, F., Hu, B., Cheng, J.-W., Sun, Y.-F., Zhou, K.-Q., Wang, P.-X., Guo, W., Zhou, J., Fan, J., Chen, Z., & Yang, X.-R. (2020). Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinoma. Cell Death & Disease, 11(7), 1–14. https://doi.org/10.1038/s41419-020-02749-7 Cite
The human HEPC-CB.1 cell line with many characteristics of endothelial progenitor cells was tested for its proangiogenic properties as a potentially therapeutic compound.
[Molecular Biology Reports]
Scientists designed multifunctional cell therapy microcarriers with the capability of sequential delivery of essential growth factors, bone morphogenetic protein 2 and vascular endothelial growth factor.
Researchers showed that HEPV bound to FGF2 through its heparin-binding site. Using in vitro and in vivo angiogenesis assays, they showed that HEPV but not the HEPV mutant at the heparin-binding site, inhibited FGF2-dependent angiogenesis.
Suprachoroidal injection of nanoparticles containing a VEGF-binding protein expression plasmid significantly suppressed VEGF-induced vascular leakage and neovascularization demonstrating therapeutic potential.