A review of the bone marrow showed an increase in the number of megakaryocytes, vascular structures, as well as increased intensity of stain for VEGF, and CXC chemokine receptor 4 in rats with iron deficiency anemia compared to controls.
Investigators probed the potential of bone marrow stem cells engineered with chemically modified mRNAs encoding the hBMP-2 and VEGF-A gene to therapeutically heal bone.
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Geng, Y., Duan, H., Xu, L., Witman, N., Yan, B., Yu, Z., Wang, H., Tan, Y., Lin, L., Li, D., Bai, S., Fritsche-Danielson, R., Yuan, J., Chien, K., Wei, M., & Fu, W. (2021). BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways. Communications Biology, 4(1), 1–14. https://doi.org/10.1038/s42003-020-01606-9 Cite
Investigators tested whether fenofibrate, with its anti-inflammatory and vasoprotective effects, could improve myocardial function by activating endothelial progenitor cells through the eNOS pathway in a doxorubicin-induced cardiomyopathy mouse model.
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The authors outline the role of LOX-1 in tumor spreading and metastasis, evidencing its function in VEGF induction, HIF-1alpha activation, and MMP-9/MMP-2 expression, pushing up the neoangiogenic and the epithelial-mesenchymal transition process in glioblastoma, osteosarcoma, prostate, colon, breast, lung, and pancreatic tumors.
[Cancer Gene Therapy]
Scientists explored the effect of proprotein convertase subtilisin kexin type 9 inhibitors on circulating endothelial progenitor cells hypothesizing a possible pleiotropic effect.
[Cardiovascular Drugs and Therapy]
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Innovent Biologics, Inc. announced that BYVASDA®, a recombinant humanized anti-VEGF monoclonal antibody drug independently developed by Innovent, has been officially approved by the National Medical Products Administration of China for the treatment of adult recurrent glioblastoma, which is the third approved indication of BYVASDA® in China.
[Innovent Biologics, Inc.]
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Researchers defined the role of LINC00337 in the malignant phenotypes, especially angiogenesis, of colorectal cancer (CRC) and clarified the underlying molecular basis. Bioinformatic analyses identified promoter region methylation of CNN1 in CRC, which was further validated by BSP and MSP assays.
[Cancer Gene Therapy]
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Umbilical-cord blood vessels were isolated for decellularization and to establish endothelial cell culture. Cultured cells were characterized by immunophenotype, gene expression and in vitro angiogenesis assay.
[Journal of Materials Science-Materials in Medicine]
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Muniswami, D. M., Reddy, L. V. K., Amirtham, S. M., Babu, S., Raj, A. N., Sen, D., & Manivasagam, G. (2020). Endothelial progenitor/stem cells in engineered vessels for vascular transplantation. Journal of Materials Science: Materials in Medicine, 31(12), 119. https://doi.org/10.1007/s10856-020-06458-7 Cite
Wharton’s jelly (WJ)-MSCs were cocultured with or without endometrial stromal cells (ESCs) damaged by mifepristone. TUNEL staining assays, EdU proliferation assays, flow cytometry apoptosis assays, and western blot assays were performed to observe the reparative effect of WJ-MSCs on damaged ESCs.
[Stem Cell Research & Therapy]
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Shi, Q., Sun, B., Wang, D., Zhu, Y., Zhao, X., Yang, X., & Zhang, Y. (2020). Circ6401, a novel circular RNA, is implicated in repair of the damaged endometrium by Wharton’s jelly-derived mesenchymal stem cells through regulation of the miR-29b-1-5p/RAP1B axis. Stem Cell Research & Therapy, 11(1), 520. https://doi.org/10.1186/s13287-020-02027-5 Cite
Scientists investigated the restorative effect of placenta derived (PD)-MSCs on injured ovaries in ovariectomized rats and the ability of intravenous transplantation of PD-MSCs to enhance ovarian vasculature and follicular development.
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Cho, J., Kim, T.-H., Seok, J., Jun, J. H., Park, H., Kweon, M., Lim, J.-Y., & Kim, G. J. (2020). Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway. Laboratory Investigation, 1–14. https://doi.org/10.1038/s41374-020-00513-1 Cite
The authors demonstrated a novel mechanism for activation of GLI-mediated signaling in epithelial breast tumor cells via epithelial-to-mesenchymal transition (EMT) cell-induced production and secretion of VEGF-C.
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