Scientists utilized a β3-endonexin mutant carrying a defective nuclear localization sequence to disrupt its nuclear localization and evaluated its ability to promote HUVEC proliferation and formation of tube-like vascular structures.
[Biochemical and Biophysical Research Communications]
Scientists developed F4L5.13, a tetravalent antibody designed to induce FZD4 and LRP5 proximity in such a way as to trigger βcatenin signaling. Treatment of cultured endothelial cells with F4L5.13 rescued permeability induced by VEGF in part by promoting surface expression of junction proteins.
[EMBO Molecular Medicine]
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Chidiac, R., Abedin, Md., Macleod, G., Yang, A., Thibeault, P. E., Blazer, L. L., Adams, J. J., Zhang, L., Roehrich, H., Jo, H.-N., Seshagiri, S., Sidhu, S. S., Junge, H. J., & Angers, S. (2021). A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Molecular Medicine, n/a(n/a), e13977. https://doi.org/10.15252/emmm.202113977 Cite
The authors explored the mechanisms through which chondrocytes regulated endothelial cell migration and angiogenesis in Osteoarthritis.
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Investigators showed that that intestinal lymphatic endothelial cells (LECs) have an increasing CD36 expression from lymphatic capillaries to collecting vessels, and that LEC CD36 regulated lymphatic integrity and optimized lipid transport.
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Cifarelli, V., Appak-Baskoy, S., Peche, V. S., Kluzak, A., Shew, T., Narendran, R., Pietka, K. M., Cella, M., Walls, C. W., Czepielewski, R., Ivanov, S., Randolph, G. J., Augustin, H. G., & Abumrad, N. A. (2021). Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells. Nature Communications, 12(1), 3350. https://doi.org/10.1038/s41467-021-23808-3 Cite
In vitro biophysical and cellular analyses demonstrated that this compound bound to Von Hippel-Lindau (VHL) and inhibited the VHL–hypoxia-inducible factor-1α (HIF)-1α interaction.
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Li, G., Ko, C.-N., Li, D., Yang, C., Wang, W., Yang, G.-J., Di Primo, C., Wong, V. K. W., Xiang, Y., Lin, L., Ma, D.-L., & Leung, C.-H. (2021). A small molecule HIF-1α stabilizer that accelerates diabetic wound healing. Nature Communications, 12(1), 3363. https://doi.org/10.1038/s41467-021-23448-7 Cite
Human umbilical cord blood-MSCs were infected with the adenovirus expressing GFP-VEFG fusion protein to overexpress VEGF165 or the adenovirus expressing GFP as control.
[Journal of Gene Medicine]
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Anti-cancer activity of catechin nanoemulsions prepared from Oolong tea leaf waste was studied on prostate cancer cells DU-145 and DU-145-induced tumors in mice.
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Investigators aimed to fabricate a Matrigel scaffold loaded with human umbilical cord-derived MSCs and explore its potential to restore ovarian function and repair ovarian structures in vitro and in vivo.
[Stem Cells and Development]
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Zhou, yao, Zhou, J., Xu, X., Du, F., Nie, M., Hu, L., Ma, Y., Liu, M., Yu, S., Zhang, J., & Chen, Y. (2021). Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. https://doi.org/10.1089/scd.2021.0005 Cite
Scientists evaluated the effect of high glucose concentration on senescence in human retinal endothelial cells and modulation of that effect by Sulodexide.
Investigators showed that VEGF-dependent release of thromboxane A2 (TXA2) triggers Ca2+ transients in tumor cells, culminating in PGE2 secretion and subsequent immune evasion in the early stages of tumorigenesis.
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Konishi, Y., Ichise, H., Watabe, T., Oki, C., Tsukiji, S., Hamazaki, Y., Murakawa, Y., Takaori-Kondo, A., Terai, K., & Matsuda, M. (2021). Intravital imaging identifies the VEGF-TXA2 axis as a critical promoter of PGE2 secretion from tumor cells and immune evasion. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-4245 Cite
To develop an enzalutamide-resistant cell model for molecular mechanism investigation of enzalutamide-resistance, researchers continuously treated C4-2B cells with multiplied concentrations of enzalutamide.
[Experimental Biology and Medicine]
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