Transplantation of Human Amnion Epithelial Cells Improves Endometrial Regeneration in Rat Model of Intrauterine Adhesions

Investigators found that PKH26-labeled human amniotic epithelial cells mainly distributed in the basal layer of endometrium after transplantation.
[Stem Cells and Development]
Ouyang, X., You, S., zhang, Y., Zhang, C., Zhang, G., Shao, X., He, F., & Hu, L. (2020). Transplantation of human amnion epithelial cells improves endometrial regeneration in rat model of intrauterine adhesions. Stem Cells and Development. https://doi.org/10.1089/scd.2019.0246 Cite
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Dihydroxystilbenes Prevent Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer by Inhibiting Colon Cytokines, a Chemokine, and Programmed Cell Death-1 in C57BL/6J Mice

The three dihydroxystilbenes in this study inhibited colon carcinogenesis and tumor growth as well as increases in colon IL-1β, IL-6, MCP-1, and PD-1 levels in AOM/DDS-treated mice in vivo. The three dihydroxystilbenes also suppressed COX-2 expression in colon tumors in vivo and inhibited PD-1 elevations in M2-THP-1 macrophages in vitro.
[European Journal of Pharmacology]
Kimura, Y., Sumiyoshi, M., Kiyoi, T., & Baba, K. (2020). Dihydroxystilbenes prevent azoxymethane/dextran sulfate sodium-induced colon cancer by inhibiting colon cytokines, a chemokine, and programmed cell death-1 in C57BL/6J mice. European Journal of Pharmacology, 173445. https://doi.org/10.1016/j.ejphar.2020.173445 Cite
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Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice

Scientists determined the effects of grape antioxidants quercetin and/or resveratrol against prostate cancer in the transgenic adenocarcinoma of mouse prostate (TRAMP)-model in prevention and intervention settings.
[Cancers]
Singh, C. K., Chhabra, G., Ndiaye, M. A., Siddiqui, I. A., Panackal, J. E., Mintie, C. A., & Ahmad, N. (2020). Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice. Cancers, 12(8), 2141. https://doi.org/10.3390/cancers12082141 Cite
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Effects of Conditioned Medium from Bone Marrow Cells on Human Umbilical Cord Perivascular Cells

Investigators evaluated the effects of human bone marrow (hBM)-conditioned medium derived from different stages of hBM MSC culture on the osteogenic capacity of perivascular tissue of the human umbilical cord.
[Tissue Engineering]
Kajiyama, S., Nagashima, Y., Funatsu, T., Suzuki, T., Fukaya, M., Matsushima, Y., Nagano, T., Davies, J. E., & Gomi, K. (2020). Effects of conditioned medium from bone marrow cells on human umbilical cord perivascular cells. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2020.0025 Cite
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Interactome of miRNAs and Transcriptome of Human Umbilical Cord Endothelial Cells Exposed to Short-Term Simulated Microgravity

Deep high-throughput sequencing approach allowed researchers to analyze the miRNA and mRNA expression profiles in HUVECS cultured under gravity, and stimulated microgravity achieved with a clinostat.
[NPJ Microgravity]
Kasiviswanathan, D., Chinnasamy Perumal, R., Bhuvaneswari, S., Kumar, P., Sundaresan, L., Philip, M., Puthenpurackal Krishnankutty, S., & Chatterjee, S. (2020). Interactome of miRNAs and transcriptome of human umbilical cord endothelial cells exposed to short-term simulated microgravity. Npj Microgravity, 6(1), 1–10. https://doi.org/10.1038/s41526-020-00108-6 Cite
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Plasma Polymerized Nanoparticles Effectively Deliver Dual siRNA and Drug Therapy In Vivo

Investigators showed that plasma polymerized nanoparticles, synthesised in reactive gas discharges, could bind and effectively deliver multiple therapeutic cargo in a facile and cost-effective process compatible with up scaled commercial production.
[Scientific Reports]
Michael, P., Lam, Y. T., Filipe, E. C., Tan, R. P., Chan, A. H. P., Lee, B. S. L., Feng, N., Hung, J., Cox, T. R., Santos, M., & Wise, S. G. (2020). Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo. Scientific Reports, 10(1), 12836. https://doi.org/10.1038/s41598-020-69591-x Cite
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Overexpression of Pigment Epithelium-Derived Factor in Placenta-Derived Mesenchymal Stem Cells Promotes Mitochondrial Biogenesis in Retinal Cells

Researchers overexpressed pigment epithelium-derived factor (PEDF) in placenta-derived mesenchymal stem cells (PD-MSCsPEDF) using a nonviral gene delivery system and evaluated the characteristics of PD-MSCsPEDF and their potential regenerative effects on retinal pigment epithelial cells damaged by H2O2-induced oxidative stress.
[Laboratory Investigation]
Kim, J. Y., Park, S., Park, S. H., Lee, D., Kim, G. H., Noh, J. E., Lee, K. J., & Kim, G. J. (2020). Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells. Laboratory Investigation, 1–19. https://doi.org/10.1038/s41374-020-0470-z Cite
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Anlotinib Suppresses Tumor Progression via Blocking the VEGFR2/PI3K/Akt Cascade in Intrahepatic Cholangiocarcinoma

Using in vitro experiments, investigators found that anlotinib had significant effects on proliferation inhibition, migration and invasion restraint, and cell-cycle arrestment in intrahepatic cholangiocarcinoma.
[Cell Death & Disease]
Song, F., Hu, B., Cheng, J.-W., Sun, Y.-F., Zhou, K.-Q., Wang, P.-X., Guo, W., Zhou, J., Fan, J., Chen, Z., & Yang, X.-R. (2020). Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinoma. Cell Death & Disease, 11(7), 1–14. https://doi.org/10.1038/s41419-020-02749-7 Cite
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Activity of the Human Immortalized Endothelial Progenitor Cell Line HEPC-CB.1 Supporting In Vitro Angiogenesis

The human HEPC-CB.1 cell line with many characteristics of endothelial progenitor cells was tested for its proangiogenic properties as a potentially therapeutic compound.
[Molecular Biology Reports]
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Microfluidic Fabrication of Microcarriers with Sequential Delivery of VEGF and BMP-2 for Bone Regeneration

Scientists designed multifunctional cell therapy microcarriers with the capability of sequential delivery of essential growth factors, bone morphogenetic protein 2 and vascular endothelial growth factor.
[Scientific Reports]
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A Collagen Vα1-Derived Fragment Inhibits FGF-2 Induced-Angiogenesis by Modulating Endothelial Cells Plasticity through Its Heparin-Binding Site

Researchers showed that HEPV bound to FGF2 through its heparin-binding site. Using in vitro and in vivo angiogenesis assays, they showed that HEPV but not the HEPV mutant at the heparin-binding site, inhibited FGF2-dependent angiogenesis.
[Matrix Biology]
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Suprachoroidal Gene Transfer with Nonviral Nanoparticles

Suprachoroidal injection of nanoparticles containing a VEGF-binding protein expression plasmid significantly suppressed VEGF-induced vascular leakage and neovascularization demonstrating therapeutic potential.
[Science Advances]
Shen, J., Kim, J., Tzeng, S. Y., Ding, K., Hafiz, Z., Long, D., Wang, J., Green, J. J., & Campochiaro, P. A. (2020). Suprachoroidal gene transfer with nonviral nanoparticles. Science Advances, 6(27), eaba1606. https://doi.org/10.1126/sciadv.aba1606 Cite
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