smooth muscle cells

[Circulation Research] Scientists generated transgenic (Tg) rabbits with smooth muscle cell-specific PGC1α overexpression and showed that these rabbits developed significantly less aortic atherosclerosis than their non-Tg littermates after high-cholesterol diet feeding, while total plasma cholesterol levels were similar.

[Journal of Cellular and Molecular Medicine] The authors investigated the function of circ_0002984 in vascular smooth muscle cells (VSMCs) incubated by oxidized low-density lipoprotein (ox-LDL). Loss of circ_0002984 suppressed VSMC viability, cell cycle distribution and migration capacity.

[Pharmacological Reports] Electrophysiological recordings were performed in freshly isolated coronary arterial smooth muscle cells to investigate the inhibitory effect of olanzapine on voltage-dependent K+ channels.

[Journal of Biochemical and Molecular Toxicology] Using human vascular smooth muscle cells (VSMCs) treated by oxidized low-density lipoprotein to establish an atherosclerosis cell model, researchers explored the functional roles and molecular mechanisms of miR-141-5p in VSMCs dysfunction.

[Molecular Medicine Reports] The authors investigated the role of high shear stress (HSS) in atherosclerotic plaque formation. In vitro modeling used human umbilical vein endothelial cells and vascular smooth muscle cells exposed to HSS using a parallel‑plate flow system.

[Circulation] Scientists employed the sex-mismatched murine aortic graft model of graft arteriopathy in wild type and inducible smooth muscle-specific Tet2 knockout mice, and in vitro studies in vascular smooth muscle cells (VSMCs) to assess the role of TET2 in VSMC responses to IFNу, a cytokine elaborated by T cells that drives coronary allograft vasculopathy progression.