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smooth muscle cells

Aged Bone Matrix-Derived Extracellular Vesicles as a Messenger for Calcification Paradox

[Nature Communications] The authors showed that extracellular vesicles derived from aged bone matrix during bone resorption favored bone marrow MSC adipogenesis rather than osteogenesis and augmented calcification of vascular smooth muscle cells.

Vascular Hyperacetylation Is Associated with Vascular Smooth Muscle Dysfunction in a Rat Model of Non-Obese Type 2 Diabetes

[Molecular Medicine] THe authors hypothesized that vascular smooth muscle cell undergoes dysregulation in advanced type 2 diabetes mellitus which was associated with vascular hyperacetylation.

Platelet-Derived TGF (Transforming Growth Factor)-β1 Enhances the Aerobic Glycolysis of Pulmonary Arterial Smooth Muscle Cells by PKM2 Upregulation

[Hypertension] Researchers investigated pulmonary arterial smooth muscle cell aerobic glycolysis after being treated with platelet supernatant. TGF-βRI, PKM2, and other antagonists were applied to identify the underlying mechanism

Apolipoprotein J Attenuates Vascular Restenosis by Promoting Autophagy and Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells

[Journal of Cardiovascular Translational Research] The interaction between ATG and LC3 was analyzed, followed by validation of the role of autophagy in CLU's regulation on the proliferation and migration of VSMCs.

Human Pulmonary Artery Smooth Muscle Cell Dysfunction Is Regulated by miR-509-5p in Hypoxic Environment

[Cell Cycle] The role of miR-509-5p in hypoxia-induced pulmonary arterial smooth muscle cells (PASMCs) and the underlying mechanism were explored. PASMCs were cultured under both normoxia and hypoxia conditions.

Curcumin Alleviates Lipopolysaccharides-Induced Inflammation and Apoptosis in Vascular Smooth Muscle Cells via Inhibition of the NF-κB and JNK Signaling Pathways

[inflammopharmacology] Researchers investigated the effect of curcumin on vascular smooth muscle cells inflammation induced by lipopolysaccharide and its mechanism.

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